Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development.
Pathogens can substantially alter gene expression within an infected host depending on metabolic or virulence requirements in different tissues, however, the effect of these alterations on host immunity are unclear. Here we visualized multiple CD4 T cell responses to temporally expressed proteins in...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002499&type=printable |
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| _version_ | 1841527078255591424 |
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| author | Seung-Joo Lee James B McLachlan Jonathan R Kurtz Danhua Fan Sebastian E Winter Andreas J Baumler Marc K Jenkins Stephen J McSorley |
| author_facet | Seung-Joo Lee James B McLachlan Jonathan R Kurtz Danhua Fan Sebastian E Winter Andreas J Baumler Marc K Jenkins Stephen J McSorley |
| author_sort | Seung-Joo Lee |
| collection | DOAJ |
| description | Pathogens can substantially alter gene expression within an infected host depending on metabolic or virulence requirements in different tissues, however, the effect of these alterations on host immunity are unclear. Here we visualized multiple CD4 T cell responses to temporally expressed proteins in Salmonella-infected mice. Flagellin-specific CD4 T cells expanded and contracted early, differentiated into Th1 and Th17 lineages, and were enriched in mucosal tissues after oral infection. In contrast, CD4 T cells responding to Salmonella Type-III Secretion System (TTSS) effectors steadily accumulated until bacterial clearance was achieved, primarily differentiated into Th1 cells, and were predominantly detected in systemic tissues. Thus, pathogen regulation of antigen expression plays a major role in orchestrating the expansion, differentiation, and location of antigen-specific CD4 T cells in vivo. |
| format | Article |
| id | doaj-art-1386ede2ca8c4a21bf702e216dbd0749 |
| institution | Kabale University |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-1386ede2ca8c4a21bf702e216dbd07492025-01-16T05:31:01ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742012-01-0181e100249910.1371/journal.ppat.1002499Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development.Seung-Joo LeeJames B McLachlanJonathan R KurtzDanhua FanSebastian E WinterAndreas J BaumlerMarc K JenkinsStephen J McSorleyPathogens can substantially alter gene expression within an infected host depending on metabolic or virulence requirements in different tissues, however, the effect of these alterations on host immunity are unclear. Here we visualized multiple CD4 T cell responses to temporally expressed proteins in Salmonella-infected mice. Flagellin-specific CD4 T cells expanded and contracted early, differentiated into Th1 and Th17 lineages, and were enriched in mucosal tissues after oral infection. In contrast, CD4 T cells responding to Salmonella Type-III Secretion System (TTSS) effectors steadily accumulated until bacterial clearance was achieved, primarily differentiated into Th1 cells, and were predominantly detected in systemic tissues. Thus, pathogen regulation of antigen expression plays a major role in orchestrating the expansion, differentiation, and location of antigen-specific CD4 T cells in vivo.https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002499&type=printable |
| spellingShingle | Seung-Joo Lee James B McLachlan Jonathan R Kurtz Danhua Fan Sebastian E Winter Andreas J Baumler Marc K Jenkins Stephen J McSorley Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development. PLoS Pathogens |
| title | Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development. |
| title_full | Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development. |
| title_fullStr | Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development. |
| title_full_unstemmed | Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development. |
| title_short | Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development. |
| title_sort | temporal expression of bacterial proteins instructs host cd4 t cell expansion and th17 development |
| url | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002499&type=printable |
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