The influence of hepatocyte growth factor on the proliferation and differentiation of stem cells
Background: The HGF/c-Met signaling pathway is central to various biological processes, including tissue regeneration, cell proliferation, and differentiation. Dysregulation of this pathway has been implicated in cancer progression and poor prognosis. Despite its potential as a therapeutic target,...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Kazimierz Wielki University
2025-01-01
|
| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/57418 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841554916486676480 |
|---|---|
| author | Rafał Bieś Agnieszka Mikosińska Jakub Parys Mateusz Litwin Patrycja Kałuziak Marta Jajczak Maciej Mossakowski Aleksandra Witek Martyna Kaźmierczak Stanisław Jesionek |
| author_facet | Rafał Bieś Agnieszka Mikosińska Jakub Parys Mateusz Litwin Patrycja Kałuziak Marta Jajczak Maciej Mossakowski Aleksandra Witek Martyna Kaźmierczak Stanisław Jesionek |
| author_sort | Rafał Bieś |
| collection | DOAJ |
| description |
Background: The HGF/c-Met signaling pathway is central to various biological processes, including tissue regeneration, cell proliferation, and differentiation. Dysregulation of this pathway has been implicated in cancer progression and poor prognosis. Despite its potential as a therapeutic target, the complexity of HGF/c-Met signaling and the associated challenges, such as off-target effects and limited understanding of its role in different disease contexts, pose significant obstacles to clinical translation.
Objectives: This review aims to examine the role of the HGF/c-Met pathway in tissue regeneration and cancer, with a focus on its therapeutic potential. We explore how HGF/c-Met signaling contributes to stem cell function, tissue repair, and cancer biology, as well as the development of targeted therapies aimed at modulating this pathway.
Methods: A thorough review of the literature was conducted, focusing on studies examining HGF/c-Met signaling in cancer and tissue regeneration. Relevant research databases were explored to identify key findings related to HGF/c-Met interactions, the effects of HGF on stem cell function, and the development of therapeutic agents targeting this pathway.
Conclusions: The HGF/c-Met pathway holds significant promise in both cancer treatment and tissue regeneration, particularly through its role in stem cell biology. Further research is needed to better understand its mechanisms and optimize targeted therapies. Combining pharmacological agents that modulate HGF/c-Met signaling with personalized treatment approaches could enhance therapeutic outcomes for cancer patients. Addressing current limitations, including the refinement of diagnostic and therapeutic strategies, will be essential in fully harnessing the potential of HGF/c-Met in clinical practice.
|
| format | Article |
| id | doaj-art-137b119fe5dc44c781cc37d43aece4f6 |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-137b119fe5dc44c781cc37d43aece4f62025-01-08T08:16:37ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-01-017710.12775/JEHS.2025.77.57418The influence of hepatocyte growth factor on the proliferation and differentiation of stem cellsRafał Bieś0https://orcid.org/0009-0005-0583-6661Agnieszka Mikosińska1https://orcid.org/0009-0003-0891-9089Jakub Parys2https://orcid.org/0009-0009-1955-7865Mateusz Litwin3https://orcid.org/0009-0006-5131-1863Patrycja Kałuziak4https://orcid.org/0009-0008-0976-1523Marta Jajczak5https://orcid.org/0009-0009-6000-7769Maciej Mossakowski6https://orcid.org/0009-0008-0423-2083Aleksandra Witek7https://orcid.org/0009-0002-1214-2199Martyna Kaźmierczak8https://orcid.org/0009-0007-7798-0069Stanisław Jesionek9https://orcid.org/0009-0004-6026-702XMedical University of Silesia, Faculty of Medical Sciences in Katowice, ul. Medyków 18, 40-752 Katowice, PolandCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Łódź, PolandCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Łódź, PolandUniversity Clinical Hospital No.2 of Medical University of Lodz, ul. Żeromskiego 113, 90-549 Łódź, PolandCharles Jonscher Medical Center, ul. Milionowa 14, 93-113 Łódź, PolandUniversity Clinical Hospital No.2 of Medical University of Lodz, ul. Żeromskiego 113, 90-549 Łódź, PolandCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Łódź, PolandCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Łódź, PolandCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Łódź, PolandPabianice Medical Center Sp. o.o., ul. Jana Pawła II 68, 95-200 Pabianice, Poland Background: The HGF/c-Met signaling pathway is central to various biological processes, including tissue regeneration, cell proliferation, and differentiation. Dysregulation of this pathway has been implicated in cancer progression and poor prognosis. Despite its potential as a therapeutic target, the complexity of HGF/c-Met signaling and the associated challenges, such as off-target effects and limited understanding of its role in different disease contexts, pose significant obstacles to clinical translation. Objectives: This review aims to examine the role of the HGF/c-Met pathway in tissue regeneration and cancer, with a focus on its therapeutic potential. We explore how HGF/c-Met signaling contributes to stem cell function, tissue repair, and cancer biology, as well as the development of targeted therapies aimed at modulating this pathway. Methods: A thorough review of the literature was conducted, focusing on studies examining HGF/c-Met signaling in cancer and tissue regeneration. Relevant research databases were explored to identify key findings related to HGF/c-Met interactions, the effects of HGF on stem cell function, and the development of therapeutic agents targeting this pathway. Conclusions: The HGF/c-Met pathway holds significant promise in both cancer treatment and tissue regeneration, particularly through its role in stem cell biology. Further research is needed to better understand its mechanisms and optimize targeted therapies. Combining pharmacological agents that modulate HGF/c-Met signaling with personalized treatment approaches could enhance therapeutic outcomes for cancer patients. Addressing current limitations, including the refinement of diagnostic and therapeutic strategies, will be essential in fully harnessing the potential of HGF/c-Met in clinical practice. https://apcz.umk.pl/JEHS/article/view/57418hepatocyte growth factorHGF/c-MET pathwayproto-oncogene proteins c-METstem cellsstem cell differentiationstem cell proliferation |
| spellingShingle | Rafał Bieś Agnieszka Mikosińska Jakub Parys Mateusz Litwin Patrycja Kałuziak Marta Jajczak Maciej Mossakowski Aleksandra Witek Martyna Kaźmierczak Stanisław Jesionek The influence of hepatocyte growth factor on the proliferation and differentiation of stem cells Journal of Education, Health and Sport hepatocyte growth factor HGF/c-MET pathway proto-oncogene proteins c-MET stem cells stem cell differentiation stem cell proliferation |
| title | The influence of hepatocyte growth factor on the proliferation and differentiation of stem cells |
| title_full | The influence of hepatocyte growth factor on the proliferation and differentiation of stem cells |
| title_fullStr | The influence of hepatocyte growth factor on the proliferation and differentiation of stem cells |
| title_full_unstemmed | The influence of hepatocyte growth factor on the proliferation and differentiation of stem cells |
| title_short | The influence of hepatocyte growth factor on the proliferation and differentiation of stem cells |
| title_sort | influence of hepatocyte growth factor on the proliferation and differentiation of stem cells |
| topic | hepatocyte growth factor HGF/c-MET pathway proto-oncogene proteins c-MET stem cells stem cell differentiation stem cell proliferation |
| url | https://apcz.umk.pl/JEHS/article/view/57418 |
| work_keys_str_mv | AT rafałbies theinfluenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT agnieszkamikosinska theinfluenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT jakubparys theinfluenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT mateuszlitwin theinfluenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT patrycjakałuziak theinfluenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT martajajczak theinfluenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT maciejmossakowski theinfluenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT aleksandrawitek theinfluenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT martynakazmierczak theinfluenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT stanisławjesionek theinfluenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT rafałbies influenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT agnieszkamikosinska influenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT jakubparys influenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT mateuszlitwin influenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT patrycjakałuziak influenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT martajajczak influenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT maciejmossakowski influenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT aleksandrawitek influenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT martynakazmierczak influenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells AT stanisławjesionek influenceofhepatocytegrowthfactorontheproliferationanddifferentiationofstemcells |