Potential Mediating Role of Polygenic Hazard Score in the Association Between Neurofilament Light Chain and Default Mode Network Connectivity Across the Alzheimer's Disease Continuum

Potential Mediating Role of Polygenic Hazard Score in the Association Between Neurofilament Light Chain and Default Mode Network Connectivity Across the Alzheimer's Disease Continuum

Background: Alzheimer’s disease (AD) is a complex neurodegenerative disorder marked by progressive cognitive decline and disrupted brain network connectivity, particularly within the default mode network (DMN). Neurofilament light chain (NfL) serves as a biomarker for axonal injury, but the role of...

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Main Authors: Parsa Saberian, Hamide Nasiri, Fatemeh Kaffashian, Parisa Nasiriansari, Fatemeh Nazari Nasab, Niusha Mehrvarz, Fatemeh Talebizadeh, Shayan Shakeri, Mahsa Mayeli
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:IBRO Neuroscience Reports
Subjects:
Neurofilament light
Resting-state fMRI
Polygenic Hazard Score
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242125000661
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