The immunomodulatory impact of naturally derived neem leaf glycoprotein on the initiation progression model of 4NQO induced murine oral carcinogenesis: a preclinical study

The immunomodulatory impact of naturally derived neem leaf glycoprotein on the initiation progression model of 4NQO induced murine oral carcinogenesis: a preclinical study

IntroductionMurine tumor growth restriction by neem leaf glycoprotein (NLGP) was established in various transplanted models of murine sarcoma, melanoma and carcinoma. However, the role of NLGP in the sequential carcinogenic steps has not been explored. Thus, tongue carcinogenesis in Swiss mice was i...

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Main Authors: Juhina Das, Saurav Bera, Nilanjan Ganguly, Ipsita Guha, Tithi Ghosh Halder, Avishek Bhuniya, Partha Nandi, Mohona Chakravarti, Sukanya Dhar, Anirban Sarkar, Tapasi Das, Saptak Banerjee, Sandip Ghose, Anamika Bose, Rathindranath Baral
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
4NQO
CD8+ T cells
immunotherapeutics
neem leaf glycoprotein
Notch1
oral carcinogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1325161/full
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