Longevity of antibody responses is associated with distinct antigen-specific B cell subsets early after infection

Longevity of antibody responses is associated with distinct antigen-specific B cell subsets early after infection

IntroductionUpon infection, T cell-driven B cell responses in GC reactions induce memory B cells and antibody-secreting cells that secrete protective antibodies. How formation of specifically long-lived plasma cells is regulated via the interplay between specific B and CD4+ T cells is not well under...

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Main Authors: Lisan H. Kuijper, Christine Kreher, George Elias, Mathieu Claireaux, Gius Kerster, Amélie V. Bos, Mariël C. Duurland, Veronique A. L. Konijn, Alberta G. A. Paul, Nina de Jong, Rivka de Jongh, Maurice Steenhuis, Juan J. Garcia-Vallejo, Marit J. van Gils, Taco W. Kuijpers, Filip Eftimov, Theo Rispens, C. Ellen van der Schoot, S. Marieke van Ham, Anja ten Brinke
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
declining/sustained antibody titers
deep-phenotyping
SARS-CoV-2
CD4+ T cells
neutralization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1505719/full
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