Assessment of the protective effects of pomegranate peel extract and n-acetyl cysteine alone or in combination with ornipural® against cadmium-induced bone toxicity in rat
<b>Aim: </b>The present study was conducted to determine the effects of pomegranate peel extract (PPE) and N-acetyl Cysteine (NAC) alone or in their treatment combinations with commercial preparation Ornipural® (ORN) on bone metabolism against experimentally cadmium (Cd)-induced toxicity...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2024-03-01
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1443 |
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| Summary: | <b>Aim: </b>The present study was conducted to determine the effects of
pomegranate peel extract (PPE) and N-acetyl Cysteine (NAC) alone or in their
treatment combinations with commercial preparation Ornipural® (ORN) on
bone metabolism against experimentally cadmium (Cd)-induced toxicity in
rats.<p>
<b>Materials and Methods: </b>Totally 36 animals were used in the study including
6 Wistar Albino rats in each group. The animals were assigned to control, Cd,
Cd+PPE, Cd+NAC, Cd+PPE+ORN and Cd+NAC+ORN groups. The animals in
the groups were euthanized after their blood samples were taken at the end
of the 8th week. The bones were subjected to maceration for morphometric
and histopathological examinations after euthanasia.<p>
<b>Results: </b>The statistically significant differences were determined between
the treatment groups and Cd group in terms of histopathological changes
(osteoporotic alterations and changes in red bone marrow) and biomarkers
(Ca, P and Mg) (P<0.05).<p>
<b>Conclusion: </b>Although PPE, NAC and treatment combinations with ORN
applied against experimentally induced cadmium toxicity were determined
to have positive effects on bone metabolism, it has been thought that carrying
out trials by increasing treatment duration and dose would be beneficial to
determine definite efficacy of the applied treatment protocols. |
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| ISSN: | 1309-6958 2146-1953 |