Lung ultrasound score to predict development of acute chest syndrome in children with sickle cell disease
Objective: This study aims to identify lung ultrasound (LUS) findings associated with acute chest syndrome (ACS) at the time of admission and 24–48 h later, to compare these to chest radiography (CXR) findings and to establish a score to predict the development of this pulmonary complication in sick...
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Elsevier
2024-11-01
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| Series: | Hematology, Transfusion and Cell Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137924003225 |
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| author | Pedro P.M.G. Vieira Josefina A.P. Braga Rodrigo Regacini |
| author_facet | Pedro P.M.G. Vieira Josefina A.P. Braga Rodrigo Regacini |
| author_sort | Pedro P.M.G. Vieira |
| collection | DOAJ |
| description | Objective: This study aims to identify lung ultrasound (LUS) findings associated with acute chest syndrome (ACS) at the time of admission and 24–48 h later, to compare these to chest radiography (CXR) findings and to establish a score to predict the development of this pulmonary complication in sickle cell disease (SCD) children Methods: A prospective observational study of SCD children presenting signs or symptoms of ACS evaluated by LUS and CXR at admission and 24–48 h later. A score was conceived to predict the evolution of ACS during hospitalization based on ultrasonographic findings. Results: Seventy-eight children were evaluated; 61 (78.2 %) developed ACS. A score greater than one at admission showed sensitivity, specificity, accuracy, and positive predictive value (PPV) of 75.4 %, 88.2 %, 78.2 %, and 95.8 %, respectively to predict ACS, while only 32 (52.5 %) CXR showed alterations. The development of ACS during hospitalization was unlikely for a score of zero and very likely for a score greater than one at admission. Regarding follow-up exams, a score greater than one showed sensitivity, specificity, accuracy, and PPV of 98.4 %, 76.5 %, 93.6 %, and 92.8 %, respectively to predict the development of ACS. ACS development was very unlikely for a score of zero and very likely for a score greater than zero in the follow-up. Conclusion: LUS is an effective tool to assess risk for the development of ACS in SCD children with clinical suspicion. |
| format | Article |
| id | doaj-art-12e451761fb241d9a6644b00bc4f18cb |
| institution | Kabale University |
| issn | 2531-1379 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj-art-12e451761fb241d9a6644b00bc4f18cb2024-12-01T05:07:48ZengElsevierHematology, Transfusion and Cell Therapy2531-13792024-11-0146S239S245Lung ultrasound score to predict development of acute chest syndrome in children with sickle cell diseasePedro P.M.G. Vieira0Josefina A.P. Braga1Rodrigo Regacini2Corresponding author at: Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM UNIFESP), Botucatu St. 598, São Paulo, SP, CEP 04023-062, Brazil.; Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM UNIFESP), São Paulo, SP, BrazilEscola Paulista de Medicina da Universidade Federal de São Paulo (EPM UNIFESP), São Paulo, SP, BrazilEscola Paulista de Medicina da Universidade Federal de São Paulo (EPM UNIFESP), São Paulo, SP, BrazilObjective: This study aims to identify lung ultrasound (LUS) findings associated with acute chest syndrome (ACS) at the time of admission and 24–48 h later, to compare these to chest radiography (CXR) findings and to establish a score to predict the development of this pulmonary complication in sickle cell disease (SCD) children Methods: A prospective observational study of SCD children presenting signs or symptoms of ACS evaluated by LUS and CXR at admission and 24–48 h later. A score was conceived to predict the evolution of ACS during hospitalization based on ultrasonographic findings. Results: Seventy-eight children were evaluated; 61 (78.2 %) developed ACS. A score greater than one at admission showed sensitivity, specificity, accuracy, and positive predictive value (PPV) of 75.4 %, 88.2 %, 78.2 %, and 95.8 %, respectively to predict ACS, while only 32 (52.5 %) CXR showed alterations. The development of ACS during hospitalization was unlikely for a score of zero and very likely for a score greater than one at admission. Regarding follow-up exams, a score greater than one showed sensitivity, specificity, accuracy, and PPV of 98.4 %, 76.5 %, 93.6 %, and 92.8 %, respectively to predict the development of ACS. ACS development was very unlikely for a score of zero and very likely for a score greater than zero in the follow-up. Conclusion: LUS is an effective tool to assess risk for the development of ACS in SCD children with clinical suspicion.http://www.sciencedirect.com/science/article/pii/S2531137924003225Sickle cell diseaseAcute chest syndromeLung ultrasoundPoint of care ultrasoundPediatricsChildren |
| spellingShingle | Pedro P.M.G. Vieira Josefina A.P. Braga Rodrigo Regacini Lung ultrasound score to predict development of acute chest syndrome in children with sickle cell disease Hematology, Transfusion and Cell Therapy Sickle cell disease Acute chest syndrome Lung ultrasound Point of care ultrasound Pediatrics Children |
| title | Lung ultrasound score to predict development of acute chest syndrome in children with sickle cell disease |
| title_full | Lung ultrasound score to predict development of acute chest syndrome in children with sickle cell disease |
| title_fullStr | Lung ultrasound score to predict development of acute chest syndrome in children with sickle cell disease |
| title_full_unstemmed | Lung ultrasound score to predict development of acute chest syndrome in children with sickle cell disease |
| title_short | Lung ultrasound score to predict development of acute chest syndrome in children with sickle cell disease |
| title_sort | lung ultrasound score to predict development of acute chest syndrome in children with sickle cell disease |
| topic | Sickle cell disease Acute chest syndrome Lung ultrasound Point of care ultrasound Pediatrics Children |
| url | http://www.sciencedirect.com/science/article/pii/S2531137924003225 |
| work_keys_str_mv | AT pedropmgvieira lungultrasoundscoretopredictdevelopmentofacutechestsyndromeinchildrenwithsicklecelldisease AT josefinaapbraga lungultrasoundscoretopredictdevelopmentofacutechestsyndromeinchildrenwithsicklecelldisease AT rodrigoregacini lungultrasoundscoretopredictdevelopmentofacutechestsyndromeinchildrenwithsicklecelldisease |