Association between serum calcium and in-hospital mortality in critically ill atrial fibrillation patients from the MIMIC IV database
Abstract Thongprayoon et al. found in a study of 12,599 non-dialysis adult hospitalized patients that serum calcium (SC) disturbances affected more than half of the patients and were associated with increased in-hospital mortality. Similar impacts of SC disturbances on in-hospital mortality have bee...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-11-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-79015-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846165235890651136 |
|---|---|
| author | Xin Zheng Fenfang Zhang Leigang Wang Hongxuan Fan Bing Yu Xiaogang Qi Bin Liang |
| author_facet | Xin Zheng Fenfang Zhang Leigang Wang Hongxuan Fan Bing Yu Xiaogang Qi Bin Liang |
| author_sort | Xin Zheng |
| collection | DOAJ |
| description | Abstract Thongprayoon et al. found in a study of 12,599 non-dialysis adult hospitalized patients that serum calcium (SC) disturbances affected more than half of the patients and were associated with increased in-hospital mortality. Similar impacts of SC disturbances on in-hospital mortality have been observed in patients with acute myocardial infarction and the general hospitalized population. Atrial fibrillation (AF), the most common arrhythmia in the intensive care unit (ICU), affects around 6% of critically ill patients. However, the significance of the relationship between SC levels and in-hospital mortality in these patients remains unclear. This study aimed to explore the correlation between SC levels and in-hospital mortality in ICU patients diagnosed with AF. Data from the MIMIC-IV database included 11,621 AF patients (average age 75.59 ± 11.74 years; 42.56% male), with an in-hospital mortality rate of 8.90%. A nonlinear relationship between SC levels and in-hospital mortality was observed. Effect sizes on either side of the inflection point were 0.79 (HR: 0.79, 95% CI 0.67–0.94, P = 0.006) and 1.12 (HR: 1.12, 95% CI 1.01–1.25, P = 0.029). Sensitivity analyses confirmed these results. SC levels around 8.56 mg/dL were associated with the lowest risk of in-hospital mortality, with risks increasing as SC levels deviated from this point. SC levels below this inflection point were linked to more pronounced clinical impacts. This finding has significant clinical implications for clinicians. Therefore, in the treatment of ICU patients with AF, clinicians should closely monitor SC levels, with a focus on maintaining them around 8.56 mg/dL. |
| format | Article |
| id | doaj-art-12c0b3599b8148e7b1ca9dfc804d97da |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-12c0b3599b8148e7b1ca9dfc804d97da2024-11-17T12:24:37ZengNature PortfolioScientific Reports2045-23222024-11-0114111010.1038/s41598-024-79015-9Association between serum calcium and in-hospital mortality in critically ill atrial fibrillation patients from the MIMIC IV databaseXin Zheng0Fenfang Zhang1Leigang Wang2Hongxuan Fan3Bing Yu4Xiaogang Qi5Bin Liang6Department of Cardiology, Second Hospital of Shanxi Medical UniversityDepartment of Cardiology, Yangquan First People’s HospitalDepartment of Cardiology, Second Hospital of Shanxi Medical UniversityDepartment of Cardiology, Second Hospital of Shanxi Medical UniversityDepartment of Cardiology, Second Hospital of Shanxi Medical UniversityDepartment of Cardiology, Second Hospital of Shanxi Medical UniversityDepartment of Cardiology, Second Hospital of Shanxi Medical UniversityAbstract Thongprayoon et al. found in a study of 12,599 non-dialysis adult hospitalized patients that serum calcium (SC) disturbances affected more than half of the patients and were associated with increased in-hospital mortality. Similar impacts of SC disturbances on in-hospital mortality have been observed in patients with acute myocardial infarction and the general hospitalized population. Atrial fibrillation (AF), the most common arrhythmia in the intensive care unit (ICU), affects around 6% of critically ill patients. However, the significance of the relationship between SC levels and in-hospital mortality in these patients remains unclear. This study aimed to explore the correlation between SC levels and in-hospital mortality in ICU patients diagnosed with AF. Data from the MIMIC-IV database included 11,621 AF patients (average age 75.59 ± 11.74 years; 42.56% male), with an in-hospital mortality rate of 8.90%. A nonlinear relationship between SC levels and in-hospital mortality was observed. Effect sizes on either side of the inflection point were 0.79 (HR: 0.79, 95% CI 0.67–0.94, P = 0.006) and 1.12 (HR: 1.12, 95% CI 1.01–1.25, P = 0.029). Sensitivity analyses confirmed these results. SC levels around 8.56 mg/dL were associated with the lowest risk of in-hospital mortality, with risks increasing as SC levels deviated from this point. SC levels below this inflection point were linked to more pronounced clinical impacts. This finding has significant clinical implications for clinicians. Therefore, in the treatment of ICU patients with AF, clinicians should closely monitor SC levels, with a focus on maintaining them around 8.56 mg/dL.https://doi.org/10.1038/s41598-024-79015-9Atrial fibrillationSerum calciumIn-hospital mortalityIntensive care unitNonlinearMIMIC-IV database |
| spellingShingle | Xin Zheng Fenfang Zhang Leigang Wang Hongxuan Fan Bing Yu Xiaogang Qi Bin Liang Association between serum calcium and in-hospital mortality in critically ill atrial fibrillation patients from the MIMIC IV database Scientific Reports Atrial fibrillation Serum calcium In-hospital mortality Intensive care unit Nonlinear MIMIC-IV database |
| title | Association between serum calcium and in-hospital mortality in critically ill atrial fibrillation patients from the MIMIC IV database |
| title_full | Association between serum calcium and in-hospital mortality in critically ill atrial fibrillation patients from the MIMIC IV database |
| title_fullStr | Association between serum calcium and in-hospital mortality in critically ill atrial fibrillation patients from the MIMIC IV database |
| title_full_unstemmed | Association between serum calcium and in-hospital mortality in critically ill atrial fibrillation patients from the MIMIC IV database |
| title_short | Association between serum calcium and in-hospital mortality in critically ill atrial fibrillation patients from the MIMIC IV database |
| title_sort | association between serum calcium and in hospital mortality in critically ill atrial fibrillation patients from the mimic iv database |
| topic | Atrial fibrillation Serum calcium In-hospital mortality Intensive care unit Nonlinear MIMIC-IV database |
| url | https://doi.org/10.1038/s41598-024-79015-9 |
| work_keys_str_mv | AT xinzheng associationbetweenserumcalciumandinhospitalmortalityincriticallyillatrialfibrillationpatientsfromthemimicivdatabase AT fenfangzhang associationbetweenserumcalciumandinhospitalmortalityincriticallyillatrialfibrillationpatientsfromthemimicivdatabase AT leigangwang associationbetweenserumcalciumandinhospitalmortalityincriticallyillatrialfibrillationpatientsfromthemimicivdatabase AT hongxuanfan associationbetweenserumcalciumandinhospitalmortalityincriticallyillatrialfibrillationpatientsfromthemimicivdatabase AT bingyu associationbetweenserumcalciumandinhospitalmortalityincriticallyillatrialfibrillationpatientsfromthemimicivdatabase AT xiaogangqi associationbetweenserumcalciumandinhospitalmortalityincriticallyillatrialfibrillationpatientsfromthemimicivdatabase AT binliang associationbetweenserumcalciumandinhospitalmortalityincriticallyillatrialfibrillationpatientsfromthemimicivdatabase |