Ruxolitinib and oHSV combination therapy increases CD4 T cell activity and germinal center B cell populations in murine sarcoma

Ruxolitinib and oHSV combination therapy increases CD4 T cell activity and germinal center B cell populations in murine sarcoma

Malignant peripheral nerve sheath tumors (MPNSTs) are a highly aggressive neoplasm of the peripheral nervous system and are resistant to most conventional cancer therapies. We previously showed that pretreatment with ruxolitinib (RUX) enhanced the efficacy of oncolytic herpes simplex virus (oHSV) vi...

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Bibliographic Details
Main Authors: Ravi Dhital, Yeaseul Kim, Doyeon Kim, Ilse Hernandez-Aguirre, Jack Hedberg, Alexia Martin, Kevin A. Cassady
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Oncology
Subjects:
MPNST
ruxolitinib
oncolytic HSV
spectral flow cytometry
cytotoxic CD4(+) T cells
germinal center B cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924001711
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