Alkaloids with Their Protective Effects Against A<i>β</i><sub>25-35</sub>-Induced PC-12 Cell Injury from the Tubers of <i>Pinellia pedatisecta</i> Schott

Alkaloids with Their Protective Effects Against A<i>β</i><sub>25-35</sub>-Induced PC-12 Cell Injury from the Tubers of <i>Pinellia pedatisecta</i> Schott

Seven new alkaloids [<b>1</b>, (±)-<b>2</b>, (±)-<b>3</b>, <b>4</b>, and <b>5</b>] and one new natural product (<b>6</b>), along with eight known analogues, were isolated from the tubers of <i>Pinellia pedatisecta</i>...

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Bibliographic Details
Main Authors:	Xu Chen, Yangang Cao, Kaili Ye, Yanling Liu, Fangge Chi, Ying Niu, Di Lu, Bingxian Zhao, Lan Chen, Xiaoke Zheng, Weisheng Feng
Format:	Article
Language:	English
Published:	MDPI AG 2024-10-01
Series:	Molecules
Subjects:	<i>Pinellia pedatisecta</i> Schott Araceae alkaloids PC-12 cell injury
Online Access:	https://www.mdpi.com/1420-3049/29/21/5059
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Summary:	Seven new alkaloids [<b>1</b>, (±)-<b>2</b>, (±)-<b>3</b>, <b>4</b>, and <b>5</b>] and one new natural product (<b>6</b>), along with eight known analogues, were isolated from the tubers of <i>Pinellia pedatisecta</i> Schott. Their structures were determined by a comprehensive analysis of spectroscopic data, including HRESIMS, and electronic circular dichroism (ECD). In addition, the results of the bioactivity evaluation showed that compounds (±)-<b>3</b>, <b>6</b>, and <b>9</b> exhibited significantly protective effects against A<i>β</i><sub>25-35</sub>-induced PC-12 cell injury and ameliorated cell viabilities by decreasing the levels of the reactive oxidative species (ROS) and mitochondrial membrane potential (MMP).
ISSN:	1420-3049