Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome

Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome

Abstract Nuclear morphology plays a critical role in regulating gene expression and cell functions. While most research has focused on the direct effects of nuclear morphology on cell fate, its impact on the cell secretome and surrounding cells remains largely unexplored. In this study, we fabricate...

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Main Authors: Xinlong Wang, Yiming Li, Zitong Lin, Indira Pla, Raju Gajjela, Basil Baby Mattamana, Maya Joshi, Yugang Liu, Huifeng Wang, Amy B. Zun, Hao Wang, Ching-Man Wai, Vasundhara Agrawal, Cody L. Dunton, Chongwen Duan, Bin Jiang, Vadim Backman, Tong-Chuan He, Russell R. Reid, Yuan Luo, Guillermo A. Ameer
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60760-y
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