Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic markers of COVID-19 irrespective of patients immunosuppression status: a case-control retrospective single-center study
AIM: To identify hematological indicators as prognostic tools in hospitalized patients with COVID-19 pneumonia, with or without immunosuppression. BACKGROUND: COVID-19 is often accompanied by severe inflammation and changes in biochemical and hematological parameters. NLR and PLR could have prognost...
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Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221371652400417X |
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| author | Amalia Papanikolopoulou Eftychia Eirini Maria Gourdoupari Polyxeni Alexiou Charalampos Charalampous Vasiliki Rapti Maria Effrosyni Livanou Eleni Kakalou Vissaria Sakka Konstantinos N Syrigos Garyfallia Poulakou |
| author_facet | Amalia Papanikolopoulou Eftychia Eirini Maria Gourdoupari Polyxeni Alexiou Charalampos Charalampous Vasiliki Rapti Maria Effrosyni Livanou Eleni Kakalou Vissaria Sakka Konstantinos N Syrigos Garyfallia Poulakou |
| author_sort | Amalia Papanikolopoulou |
| collection | DOAJ |
| description | AIM: To identify hematological indicators as prognostic tools in hospitalized patients with COVID-19 pneumonia, with or without immunosuppression. BACKGROUND: COVID-19 is often accompanied by severe inflammation and changes in biochemical and hematological parameters. NLR and PLR could have prognostic potential in SARS-CoV-2 infection. METHODS: We retrospectively analyzed patients with COVID-19 pneumonia, sequentially admitted to our Infectious Diseases Department, from June 2021 to December 2022, after the implementation of massive SARS-CoV-2 vaccination programs in Greece. Hospitalized patients were divided in two cohorts according to immunosuppression status, using a propensity score-matching in 1:2 ratio. RESULTS: In total 393 from 400 collected patients (n=131, 33.3% immunocompromised with prior medical history of either hematological malignancy or autoimmune condition and n=262, 66.7% non-immunocompromised) were enrolled: male: n=199(50.6%); mean age 64.7 (SD=16.1) (Table1). According to WHO criteria most of the patients (n=211, 54%) had severe COVID-19 and were vaccinated against COVID-19 (n=209, 53.9%). Median duration of hospitalization was significantly higher in immunocompromised patients [10, IQR (7-16), p=0.036], while intubation and survival weren't significantly different between two groups (p=0.972, 0.756 respectively) (Figure 1). Biochemical and hematological parameters on day 1 and 4 of hospitalization weren't significantly different between two groups (Table 2). In contrast higher NLR values on day 1 were observed for Omicron variant and higher NLR and PLR values on day 1 and 4 for severe COVID-19 (Table 3). CONCLUSIONS: During the 3rd and 4th pandemic wave, NLR and PLR values display promising prognostic markers, irrespective of immunosuppression status, of COVID-19 hospitalized patients. |
| format | Article |
| id | doaj-art-121150b7ad104d9c91e8058f7d3b3746 |
| institution | Kabale University |
| issn | 2213-7165 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-121150b7ad104d9c91e8058f7d3b37462024-12-27T04:08:53ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-12-01397475Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic markers of COVID-19 irrespective of patients immunosuppression status: a case-control retrospective single-center studyAmalia Papanikolopoulou0Eftychia Eirini Maria Gourdoupari1Polyxeni Alexiou2Charalampos Charalampous3Vasiliki Rapti4Maria Effrosyni Livanou5Eleni Kakalou6Vissaria Sakka7Konstantinos N Syrigos8Garyfallia Poulakou9Third Department of Internal Medicine, Sotiria General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceThird Department of Internal Medicine, Sotiria General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceThird Department of Internal Medicine, Sotiria General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceThird Department of Internal Medicine, Sotiria General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceThird Department of Internal Medicine, Sotiria General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceThird Department of Internal Medicine, Sotiria General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceThird Department of Internal Medicine, Sotiria General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceThird Department of Internal Medicine, Sotiria General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceThird Department of Internal Medicine, Sotiria General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceThird Department of Internal Medicine, Sotiria General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceAIM: To identify hematological indicators as prognostic tools in hospitalized patients with COVID-19 pneumonia, with or without immunosuppression. BACKGROUND: COVID-19 is often accompanied by severe inflammation and changes in biochemical and hematological parameters. NLR and PLR could have prognostic potential in SARS-CoV-2 infection. METHODS: We retrospectively analyzed patients with COVID-19 pneumonia, sequentially admitted to our Infectious Diseases Department, from June 2021 to December 2022, after the implementation of massive SARS-CoV-2 vaccination programs in Greece. Hospitalized patients were divided in two cohorts according to immunosuppression status, using a propensity score-matching in 1:2 ratio. RESULTS: In total 393 from 400 collected patients (n=131, 33.3% immunocompromised with prior medical history of either hematological malignancy or autoimmune condition and n=262, 66.7% non-immunocompromised) were enrolled: male: n=199(50.6%); mean age 64.7 (SD=16.1) (Table1). According to WHO criteria most of the patients (n=211, 54%) had severe COVID-19 and were vaccinated against COVID-19 (n=209, 53.9%). Median duration of hospitalization was significantly higher in immunocompromised patients [10, IQR (7-16), p=0.036], while intubation and survival weren't significantly different between two groups (p=0.972, 0.756 respectively) (Figure 1). Biochemical and hematological parameters on day 1 and 4 of hospitalization weren't significantly different between two groups (Table 2). In contrast higher NLR values on day 1 were observed for Omicron variant and higher NLR and PLR values on day 1 and 4 for severe COVID-19 (Table 3). CONCLUSIONS: During the 3rd and 4th pandemic wave, NLR and PLR values display promising prognostic markers, irrespective of immunosuppression status, of COVID-19 hospitalized patients.http://www.sciencedirect.com/science/article/pii/S221371652400417XCOVID-19 infectionimmunosuppressionhospitalized patientsneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratio |
| spellingShingle | Amalia Papanikolopoulou Eftychia Eirini Maria Gourdoupari Polyxeni Alexiou Charalampos Charalampous Vasiliki Rapti Maria Effrosyni Livanou Eleni Kakalou Vissaria Sakka Konstantinos N Syrigos Garyfallia Poulakou Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic markers of COVID-19 irrespective of patients immunosuppression status: a case-control retrospective single-center study Journal of Global Antimicrobial Resistance COVID-19 infection immunosuppression hospitalized patients neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio |
| title | Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic markers of COVID-19 irrespective of patients immunosuppression status: a case-control retrospective single-center study |
| title_full | Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic markers of COVID-19 irrespective of patients immunosuppression status: a case-control retrospective single-center study |
| title_fullStr | Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic markers of COVID-19 irrespective of patients immunosuppression status: a case-control retrospective single-center study |
| title_full_unstemmed | Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic markers of COVID-19 irrespective of patients immunosuppression status: a case-control retrospective single-center study |
| title_short | Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic markers of COVID-19 irrespective of patients immunosuppression status: a case-control retrospective single-center study |
| title_sort | neutrophil to lymphocyte ratio nlr and platelet to lymphocyte ratio plr as prognostic markers of covid 19 irrespective of patients immunosuppression status a case control retrospective single center study |
| topic | COVID-19 infection immunosuppression hospitalized patients neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio |
| url | http://www.sciencedirect.com/science/article/pii/S221371652400417X |
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