Temporal dynamics of neutrophil functions in multiple sclerosis

Temporal dynamics of neutrophil functions in multiple sclerosis

Early neuroinflammatory injury plays a crucial role in initiating and progressing multiple sclerosis (MS). Neutrophils are forerunners to neural lesions in MS, yet the temporal alterations of their functions in MS remains unclear. This study demonstrated a positive correlation between circulatory ne...

Full description

Saved in:
Bibliographic Details
Main Authors: Shishi Shen, Shilin Wu, Yuge Wang, Li Xiao, Xiaobo Sun, Wenxuan Sun, Yipeng Zhao, Rui Li, Jiaqi Zhang, Zhanhang Wang, Shaoli Zhou, Shixiong Huang, Yanyu Chang, Yaqing Shu, Chen Chen, Zhengqi Lu, Wei Cai, Wei Qiu
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Neurobiology of Disease
Subjects:
Neutrophil heterogeneity
Early lesion
Demyelination
Multiple sclerosis
Blood brain barrier
Antigen presentation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124003462
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Early neuroinflammatory injury plays a crucial role in initiating and progressing multiple sclerosis (MS). Neutrophils are forerunners to neural lesions in MS, yet the temporal alterations of their functions in MS remains unclear. This study demonstrated a positive correlation between circulatory neutrophil counts and disease activity and severity in treatment-naïve MS patients. In experimental autoimmune encephalomyelitis (EAE), we documented the recruitment of neutrophils to spinal cord during the preclinical phase, with these cells contributing to the disruption of the blood-spinal cord barrier (BSCB) during the onset of the disease. Furthermore, during the peak phase, infiltrated neutrophils promoted demyelination through formation of neutrophil extracellular traps (NETs), cytokine secretion and antigen presentation. Notably, the inhibition of neutrophil infiltration using a CXCR2 inhibitor effectively mitigated white matter damage and physical disability, underscoring their potential as therapeutic targets. In conclusion, neutrophils represent promising candidates for both disease treatment and prognosis evaluation in MS. By elucidating their temporal roles and mechanisms of action, we can potentially harness their modulation to improve patient outcomes and disease management.
ISSN:1095-953X

Similar Items