Mortality of Pneumocystis jirovecii pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISG
Background Pneumocystis jirovecii pneumonia (PJP) is a life-threatening disease. In the intensive care unit (ICU), PJP is most frequently observed among patients with several conditions not related to the human immunodeficiency virus (HIV) infection.Methods The primary objective of the present post-...
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2025-12-01
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| author | Daniele Roberto Giacobbe Silvia Dettori Vincenzo Di Pilato Erika Asperges Lorenzo Ball Enora Berti Ola Blennow Bianca Bruzzone Laure Calvet Federico Capra Marzani Antonio Casabella Sofia Choudaly Anais Dartevel Gennaro De Pascale Gabriele Di Meco Melissa Fallon Louis-Marie Galerneau Miguel Gallego Mauro Giacomini Adolfo González Saez Luise Hänsel Giancarlo Icardi Philipp Koehler Katrien Lagrou Tobias Lahmer Philip Lewis White Laura Magnasco Anna Marchese Cristina Marelli Mercedes Marín Arriaza Ignacio Martin-Loeches Armand Mekontso-Dessap Malgorzata Mikulska Marco Muccio Alessandra Mularoni Anna Nordlander Julien Poissy Giovanna Russelli Alessio Signori Carlo Tascini Louis-Maxime Vaconsin Joel Vargas Antonio Vena Joost Wauters Paolo Pelosi Jean-Francois Timsit Matteo Bassetti |
| author_facet | Daniele Roberto Giacobbe Silvia Dettori Vincenzo Di Pilato Erika Asperges Lorenzo Ball Enora Berti Ola Blennow Bianca Bruzzone Laure Calvet Federico Capra Marzani Antonio Casabella Sofia Choudaly Anais Dartevel Gennaro De Pascale Gabriele Di Meco Melissa Fallon Louis-Marie Galerneau Miguel Gallego Mauro Giacomini Adolfo González Saez Luise Hänsel Giancarlo Icardi Philipp Koehler Katrien Lagrou Tobias Lahmer Philip Lewis White Laura Magnasco Anna Marchese Cristina Marelli Mercedes Marín Arriaza Ignacio Martin-Loeches Armand Mekontso-Dessap Malgorzata Mikulska Marco Muccio Alessandra Mularoni Anna Nordlander Julien Poissy Giovanna Russelli Alessio Signori Carlo Tascini Louis-Maxime Vaconsin Joel Vargas Antonio Vena Joost Wauters Paolo Pelosi Jean-Francois Timsit Matteo Bassetti |
| author_sort | Daniele Roberto Giacobbe |
| collection | DOAJ |
| description | Background Pneumocystis jirovecii pneumonia (PJP) is a life-threatening disease. In the intensive care unit (ICU), PJP is most frequently observed among patients with several conditions not related to the human immunodeficiency virus (HIV) infection.Methods The primary objective of the present post-hoc analysis of a multicenter, multinational, retrospective study was to assess factors impacting prognosis in ICU patients with PJP through univariable and multivariable analyses.Results A total of 107 patients were included; 28 had proven PJP (26.2%), and 79 had presumptive PJP (73.8%). The overall 30-day mortality was 52.7% (95% confidence interval [CI] 42.1–62.2). In the multivariable analysis, metastatic solid tumor (hazard ratio [HR] 3.49; 95% CI 1.71–7.13, p < 0.001) and chronic liver disease (HR 2.44; 95% CI 1.03–5.80, p = 0.044) showed an independent association with 30-day mortality. The direction of effect remained consistent when center was added to the multivariable model as random effect.Conclusion PJP mortality remains high in ICU patients. Conditions other than HIV infection are emerging not only as non-classical risk factors for PJP development, but also as important mortality predictors. A better understanding of the reasons underlying this evolving landscape could be crucial to improve PJP management and survival. |
| format | Article |
| id | doaj-art-11f8e275d2a6431c8cc35d26e0c3ad0d |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
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| series | Annals of Medicine |
| spelling | doaj-art-11f8e275d2a6431c8cc35d26e0c3ad0d2025-08-20T03:45:28ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2511043Mortality of Pneumocystis jirovecii pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISGDaniele Roberto Giacobbe0Silvia Dettori1Vincenzo Di Pilato2Erika Asperges3Lorenzo Ball4Enora Berti5Ola Blennow6Bianca Bruzzone7Laure Calvet8Federico Capra Marzani9Antonio Casabella10Sofia Choudaly11Anais Dartevel12Gennaro De Pascale13Gabriele Di Meco14Melissa Fallon15Louis-Marie Galerneau16Miguel Gallego17Mauro Giacomini18Adolfo González Saez19Luise Hänsel20Giancarlo Icardi21Philipp Koehler22Katrien Lagrou23Tobias Lahmer24Philip Lewis White25Laura Magnasco26Anna Marchese27Cristina Marelli28Mercedes Marín Arriaza29Ignacio Martin-Loeches30Armand Mekontso-Dessap31Malgorzata Mikulska32Marco Muccio33Alessandra Mularoni34Anna Nordlander35Julien Poissy36Giovanna Russelli37Alessio Signori38Carlo Tascini39Louis-Maxime Vaconsin40Joel Vargas41Antonio Vena42Joost Wauters43Paolo Pelosi44Jean-Francois Timsit45Matteo Bassetti46Department of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, ItalyDivision of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyDivision of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyAssistance Publique – Hôpitaux de Paris, DMU Médecine, Service de Médecine Intensive Réanimation, Hôpital Henri Mondor, Hôpitaux Universitaires Henri Mondor, Créteil, FranceDepartment of Infectious Diseases, Karolinska University Hospital, Stockholm, SwedenHygiene Unit, San Martino Policlinico Hospital – IRCCS for Oncology and Neurosciences, Genoa, ItalyService de Médecine Intensive Réanimation, CHU de Clermont-Ferrand, Clermont-Ferrand, FranceServizio di Anestesia e Rianimazione 1, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyMicrobiology Unit Laboratory Service, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT), Universitat Autònoma de Barcelona, Sabadell, SpainUnité de Glycobiologie Structurale et Fonctionnelle, Lille, FranceMedical Intensive Care Unit, Grenoble Alpes University Hospital, Grenoble, FranceDipartimento di scienze dell’emergenza, anestesiologiche e della rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyInfectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, Genoa, ItalyPublic Health Wales Mycology Reference Laboratory, PHW Microbiology Cardiff, University Hospital of Wales, Cardiff, UKMedical Intensive Care Unit, Grenoble Alpes University Hospital, Grenoble, FranceRespiratory Department, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT), Universitat Autònoma de Barcelona, Sabadell, SpainDepartment of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, Genoa, ItalyServicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Madrid, SpainDepartment I of Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University of Cologne, Medical Faculty and University Hospital Cologne, Cologne, GermanyDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyDepartment I of Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University of Cologne, Medical Faculty and University Hospital Cologne, Cologne, GermanyDepartment of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, BelgiumDepartment of Internal Medicine II, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Munich, GermanyPublic Health Wales Mycology Reference Laboratory, PHW Microbiology Cardiff, University Hospital of Wales, Cardiff, UKInfectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, Genoa, ItalyDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, ItalyInfectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, Genoa, ItalyServicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Madrid, SpainDepartment of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), Leinster, Dublin, IrelandAssistance Publique – Hôpitaux de Paris, DMU Médecine, Service de Médecine Intensive Réanimation, Hôpital Henri Mondor, Hôpitaux Universitaires Henri Mondor, Créteil, FranceDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyUnit of Infectious Diseases, ISMETT-IRCCS Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, ItalyDepartment of Infectious Diseases, Karolinska University Hospital, Stockholm, SwedenUnité de Glycobiologie Structurale et Fonctionnelle, Lille, FranceUnit of Infectious Diseases, ISMETT-IRCCS Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, ItalySection of Biostatistics, Department of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyInfectious Diseases Clinic, Azienda Sanitaria Universitaria del Friuli Centrale (ASUFC), Udine, ItalyMedical and Infectious Diseases ICU, APHP, Bichat hospital, Paris, FranceDipartimento di scienze dell’emergenza, anestesiologiche e della rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyDepartment of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, BelgiumDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, ItalyMedical and Infectious Diseases ICU, APHP, Bichat hospital, Paris, FranceDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyBackground Pneumocystis jirovecii pneumonia (PJP) is a life-threatening disease. In the intensive care unit (ICU), PJP is most frequently observed among patients with several conditions not related to the human immunodeficiency virus (HIV) infection.Methods The primary objective of the present post-hoc analysis of a multicenter, multinational, retrospective study was to assess factors impacting prognosis in ICU patients with PJP through univariable and multivariable analyses.Results A total of 107 patients were included; 28 had proven PJP (26.2%), and 79 had presumptive PJP (73.8%). The overall 30-day mortality was 52.7% (95% confidence interval [CI] 42.1–62.2). In the multivariable analysis, metastatic solid tumor (hazard ratio [HR] 3.49; 95% CI 1.71–7.13, p < 0.001) and chronic liver disease (HR 2.44; 95% CI 1.03–5.80, p = 0.044) showed an independent association with 30-day mortality. The direction of effect remained consistent when center was added to the multivariable model as random effect.Conclusion PJP mortality remains high in ICU patients. Conditions other than HIV infection are emerging not only as non-classical risk factors for PJP development, but also as important mortality predictors. A better understanding of the reasons underlying this evolving landscape could be crucial to improve PJP management and survival.https://www.tandfonline.com/doi/10.1080/07853890.2025.2511043PneumocystispneumoniaICUmortalityPCPPJP |
| spellingShingle | Daniele Roberto Giacobbe Silvia Dettori Vincenzo Di Pilato Erika Asperges Lorenzo Ball Enora Berti Ola Blennow Bianca Bruzzone Laure Calvet Federico Capra Marzani Antonio Casabella Sofia Choudaly Anais Dartevel Gennaro De Pascale Gabriele Di Meco Melissa Fallon Louis-Marie Galerneau Miguel Gallego Mauro Giacomini Adolfo González Saez Luise Hänsel Giancarlo Icardi Philipp Koehler Katrien Lagrou Tobias Lahmer Philip Lewis White Laura Magnasco Anna Marchese Cristina Marelli Mercedes Marín Arriaza Ignacio Martin-Loeches Armand Mekontso-Dessap Malgorzata Mikulska Marco Muccio Alessandra Mularoni Anna Nordlander Julien Poissy Giovanna Russelli Alessio Signori Carlo Tascini Louis-Maxime Vaconsin Joel Vargas Antonio Vena Joost Wauters Paolo Pelosi Jean-Francois Timsit Matteo Bassetti Mortality of Pneumocystis jirovecii pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISG Annals of Medicine Pneumocystis pneumonia ICU mortality PCP PJP |
| title | Mortality of Pneumocystis jirovecii pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISG |
| title_full | Mortality of Pneumocystis jirovecii pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISG |
| title_fullStr | Mortality of Pneumocystis jirovecii pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISG |
| title_full_unstemmed | Mortality of Pneumocystis jirovecii pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISG |
| title_short | Mortality of Pneumocystis jirovecii pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISG |
| title_sort | mortality of pneumocystis jirovecii pneumonia in intensive care units a post hoc analysis of an international multicenter study by esgcip and efisg |
| topic | Pneumocystis pneumonia ICU mortality PCP PJP |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2511043 |
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