CD147 Mediates the Metabolic Reprogramming of Cancer Associated Fibroblasts Induced by EVs Released by Differentiating Cancer Stem Cells

CD147 Mediates the Metabolic Reprogramming of Cancer Associated Fibroblasts Induced by EVs Released by Differentiating Cancer Stem Cells

ABSTRACT Several reports have demonstrated that CD147, an N‐glycosylated protein that is exchanged by cells in soluble form or through small extracellular vesicles (sEVs), can promote cancer progression. However, its activity related to EVs in colorectal cancer (CRC) is still not fully understood. P...

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Main Authors: Filomena Colella, Federica Calapà, Giulia Artemi, Erica Pazzaglia, Rita Colonna, Sara Vitale, Giacomo Lazzarino, Federica Vincenzoni, Micol Eleonora Fiori, Ruggero De Maria, Sara Lucchisani, Giannicola Genovese, Luigi Perelli, Barbara Tavazzi, Alessandro Sgambato, Donatella Lucchetti
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Journal of Extracellular Biology
Subjects:
cancer‐associated fibroblasts
CD147
extracellular vesicles
tumour microenvironment
Online Access:https://doi.org/10.1002/jex2.70039
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https://doi.org/10.1002/jex2.70039

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