Comments about the comparative bulk RNA sequencing between palmoplantar pustulosis and dyshidrotic palmoplantar eczema [version 1; peer review: 2 approved]
This correspondence discusses the recent findings by Straalen et al., highlighting molecular similarities and distinctions between palmoplantar pustulosis (PPP) and dyshidrotic palmoplantar eczema (DPE). The study emphasizes shared proinflammatory pathways and T-cell–related gene upregulation while...
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F1000 Research Ltd
2024-12-01
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| Online Access: | https://f1000research.com/articles/13-1494/v1 |
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| author | Masamoto Murakami Jun Muto Kazuki Yatsuzuka |
| author_facet | Masamoto Murakami Jun Muto Kazuki Yatsuzuka |
| author_sort | Masamoto Murakami |
| collection | DOAJ |
| description | This correspondence discusses the recent findings by Straalen et al., highlighting molecular similarities and distinctions between palmoplantar pustulosis (PPP) and dyshidrotic palmoplantar eczema (DPE). The study emphasizes shared proinflammatory pathways and T-cell–related gene upregulation while detailing unique features such as neutrophil involvement in PPP and lipid antigen processing in DPE. We elaborate on histopathological differences, especially intraepidermal vesicle formation in PPP linked to IL–1–mediated pathways and the absence of hyaluronan expression, contrasting with Th2 cytokines-driven spongiosis in DPE. By addressing IL-4, hyaluronan synthases, and keratinocyte adhesion molecules, this correspondence aims to deepen understanding of PPP and DPE pathophysiology. |
| format | Article |
| id | doaj-art-11b39d75d0d049548b68af3872c81927 |
| institution | Kabale University |
| issn | 2046-1402 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj-art-11b39d75d0d049548b68af3872c819272025-01-14T01:00:04ZengF1000 Research LtdF1000Research2046-14022024-12-0113175314Comments about the comparative bulk RNA sequencing between palmoplantar pustulosis and dyshidrotic palmoplantar eczema [version 1; peer review: 2 approved]Masamoto Murakami0Jun Muto1Kazuki Yatsuzuka2https://orcid.org/0000-0001-7747-0551Department of Anatomy, Miyazaki University, Miyazaki, Miyazaki Prefecture, 889-1692, JapanDepartment of Dermatology, Ehime University, Toon, Ehime Prefecture, 791-0295, JapanDepartment of Dermatology, Ehime University, Toon, Ehime Prefecture, 791-0295, JapanThis correspondence discusses the recent findings by Straalen et al., highlighting molecular similarities and distinctions between palmoplantar pustulosis (PPP) and dyshidrotic palmoplantar eczema (DPE). The study emphasizes shared proinflammatory pathways and T-cell–related gene upregulation while detailing unique features such as neutrophil involvement in PPP and lipid antigen processing in DPE. We elaborate on histopathological differences, especially intraepidermal vesicle formation in PPP linked to IL–1–mediated pathways and the absence of hyaluronan expression, contrasting with Th2 cytokines-driven spongiosis in DPE. By addressing IL-4, hyaluronan synthases, and keratinocyte adhesion molecules, this correspondence aims to deepen understanding of PPP and DPE pathophysiology.https://f1000research.com/articles/13-1494/v1palmoplantar pustulosis dyshidrotic eczema psoriasis RNA sequencing intraepidermal vesicleeng |
| spellingShingle | Masamoto Murakami Jun Muto Kazuki Yatsuzuka Comments about the comparative bulk RNA sequencing between palmoplantar pustulosis and dyshidrotic palmoplantar eczema [version 1; peer review: 2 approved] F1000Research palmoplantar pustulosis dyshidrotic eczema psoriasis RNA sequencing intraepidermal vesicle eng |
| title | Comments about the comparative bulk RNA sequencing between palmoplantar pustulosis and dyshidrotic palmoplantar eczema [version 1; peer review: 2 approved] |
| title_full | Comments about the comparative bulk RNA sequencing between palmoplantar pustulosis and dyshidrotic palmoplantar eczema [version 1; peer review: 2 approved] |
| title_fullStr | Comments about the comparative bulk RNA sequencing between palmoplantar pustulosis and dyshidrotic palmoplantar eczema [version 1; peer review: 2 approved] |
| title_full_unstemmed | Comments about the comparative bulk RNA sequencing between palmoplantar pustulosis and dyshidrotic palmoplantar eczema [version 1; peer review: 2 approved] |
| title_short | Comments about the comparative bulk RNA sequencing between palmoplantar pustulosis and dyshidrotic palmoplantar eczema [version 1; peer review: 2 approved] |
| title_sort | comments about the comparative bulk rna sequencing between palmoplantar pustulosis and dyshidrotic palmoplantar eczema version 1 peer review 2 approved |
| topic | palmoplantar pustulosis dyshidrotic eczema psoriasis RNA sequencing intraepidermal vesicle eng |
| url | https://f1000research.com/articles/13-1494/v1 |
| work_keys_str_mv | AT masamotomurakami commentsaboutthecomparativebulkrnasequencingbetweenpalmoplantarpustulosisanddyshidroticpalmoplantareczemaversion1peerreview2approved AT junmuto commentsaboutthecomparativebulkrnasequencingbetweenpalmoplantarpustulosisanddyshidroticpalmoplantareczemaversion1peerreview2approved AT kazukiyatsuzuka commentsaboutthecomparativebulkrnasequencingbetweenpalmoplantarpustulosisanddyshidroticpalmoplantareczemaversion1peerreview2approved |