Effect of gabapentin on solution surface properties and micellization behavior of betaine-based surfactant ionic liquids
Abstract This study investigates the surface properties, micellization, and electrical conductivity of betaine-based ionic liquids (ILs) composed of [R-bet][Br] where R represents the C4, C6 and C8 (specifically [C4bet][Br], [C6bet][Br], and [C8bet][Br]) in aqueous gabapentin solutions at concentrat...
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| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-83777-7 |
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| author | Shima Ghasemzadeh Mohammad Bagheri Hemayat Shekaari Behrang Golmohammadi |
| author_facet | Shima Ghasemzadeh Mohammad Bagheri Hemayat Shekaari Behrang Golmohammadi |
| author_sort | Shima Ghasemzadeh |
| collection | DOAJ |
| description | Abstract This study investigates the surface properties, micellization, and electrical conductivity of betaine-based ionic liquids (ILs) composed of [R-bet][Br] where R represents the C4, C6 and C8 (specifically [C4bet][Br], [C6bet][Br], and [C8bet][Br]) in aqueous gabapentin solutions at concentrations of (0.0000, 0.0100, 0.0300, and 0.0500) mol kg−1 at 298.15 K. The surface tension measurements revealed that increasing gabapentin concentration and alkyl chain length decrease surface tension, indicating significant hydrophobic and hydrophilic interactions. The related thermophysical micellization parameters, including critical micelle concentration (CMC) and minimum surface area per molecule (A min ), exhibited improved micellization and interfacial efficiency with longer alkyl chains. Thermodynamic analysis confirm the spontaneous nature of micelle formation, with more negative Gibbs free energy values for SAILs with longer alkyl chains. The electrical conductivity studies indicate lower limiting molar conductivity (Λ 0) at higher gabapentin concentrations, due to increased viscosity and ion-ion interactions. Ion association constants (K A ) and DFT-COSMO calculations support stronger hydrophobic interactions and molecular packing influenced by alkyl chain length and gabapentin. |
| format | Article |
| id | doaj-art-11af08f3f6b349a88b9a88c434667706 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-11af08f3f6b349a88b9a88c4346677062025-01-05T12:17:16ZengNature PortfolioScientific Reports2045-23222025-01-0115111610.1038/s41598-024-83777-7Effect of gabapentin on solution surface properties and micellization behavior of betaine-based surfactant ionic liquidsShima Ghasemzadeh0Mohammad Bagheri1Hemayat Shekaari2Behrang Golmohammadi3Department of Physical Chemistry, University of TabrizDepartment of Physical Chemistry, University of TabrizDepartment of Physical Chemistry, University of TabrizDepartment of Physical Chemistry, University of TabrizAbstract This study investigates the surface properties, micellization, and electrical conductivity of betaine-based ionic liquids (ILs) composed of [R-bet][Br] where R represents the C4, C6 and C8 (specifically [C4bet][Br], [C6bet][Br], and [C8bet][Br]) in aqueous gabapentin solutions at concentrations of (0.0000, 0.0100, 0.0300, and 0.0500) mol kg−1 at 298.15 K. The surface tension measurements revealed that increasing gabapentin concentration and alkyl chain length decrease surface tension, indicating significant hydrophobic and hydrophilic interactions. The related thermophysical micellization parameters, including critical micelle concentration (CMC) and minimum surface area per molecule (A min ), exhibited improved micellization and interfacial efficiency with longer alkyl chains. Thermodynamic analysis confirm the spontaneous nature of micelle formation, with more negative Gibbs free energy values for SAILs with longer alkyl chains. The electrical conductivity studies indicate lower limiting molar conductivity (Λ 0) at higher gabapentin concentrations, due to increased viscosity and ion-ion interactions. Ion association constants (K A ) and DFT-COSMO calculations support stronger hydrophobic interactions and molecular packing influenced by alkyl chain length and gabapentin.https://doi.org/10.1038/s41598-024-83777-7Surface tensionElectrical conductivityBetaineIonic liquidsCOSMO |
| spellingShingle | Shima Ghasemzadeh Mohammad Bagheri Hemayat Shekaari Behrang Golmohammadi Effect of gabapentin on solution surface properties and micellization behavior of betaine-based surfactant ionic liquids Scientific Reports Surface tension Electrical conductivity Betaine Ionic liquids COSMO |
| title | Effect of gabapentin on solution surface properties and micellization behavior of betaine-based surfactant ionic liquids |
| title_full | Effect of gabapentin on solution surface properties and micellization behavior of betaine-based surfactant ionic liquids |
| title_fullStr | Effect of gabapentin on solution surface properties and micellization behavior of betaine-based surfactant ionic liquids |
| title_full_unstemmed | Effect of gabapentin on solution surface properties and micellization behavior of betaine-based surfactant ionic liquids |
| title_short | Effect of gabapentin on solution surface properties and micellization behavior of betaine-based surfactant ionic liquids |
| title_sort | effect of gabapentin on solution surface properties and micellization behavior of betaine based surfactant ionic liquids |
| topic | Surface tension Electrical conductivity Betaine Ionic liquids COSMO |
| url | https://doi.org/10.1038/s41598-024-83777-7 |
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