Impact of neoadjuvant systemic therapy on surgical and radiotherapy outcomes in patients with early-stage breast cancer: a cross-sectional retrospective single-center study

Abstract Introduction Neoadjuvant systemic therapy (NST) may cause non-concentric tumor shrinkage, complicating excision volume definition and potentially increasing radiotherapy boost volumes, affecting cosmetic outcomes. This study aims to compare excision and boost volumes in patients undergoing...

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Main Authors:	Yasmin A. Civil, Katya M. Duvivier, Sanne A. L. Bartels, Susanne van der Velde, C. Willemien Menke-van der Houven van Oordt, Ellis Barbé, Suzan van der Meij, Berend J. Slotman, Desirée van den Bongard
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	BMC Cancer
Subjects:	Breast cancer Neoadjuvant systemic therapy Excision volume Boost volume Cosmetic outcome Quality of life
Online Access:	https://doi.org/10.1186/s12885-025-14438-9
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Impact of neoadjuvant systemic therapy on surgical and radiotherapy outcomes in patients with early-stage breast cancer: a cross-sectional retrospective single-center study

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