Enrichment of human IgA-coated bacterial vesicles in ulcerative colitis as a driver of inflammation

Enrichment of human IgA-coated bacterial vesicles in ulcerative colitis as a driver of inflammation

Abstract The gut microbiome contributes to chronic inflammatory responses in ulcerative colitis (UC), but molecular mechanisms and disease-relevant effectors remain unclear. Here we analyze the pro-inflammatory properties of colonic fluid obtained during colonoscopy from UC and control patients. In...

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Main Authors: Himadri B. Thapa, Christina A. Passegger, Dominik Fleischhacker, Paul Kohl, Yi-Chi Chen, Ratchara Kalawong, Carmen Tam-Amersdorfer, Michael R. Gerstorfer, Jana Strahlhofer, Kristina Schild-Prüfert, Ellen L. Zechner, Andreas Blesl, Lukas Binder, Georg A. Busslinger, Leo Eberl, Gregor Gorkiewicz, Herbert Strobl, Christoph Högenauer, Stefan Schild
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59354-5
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https://doi.org/10.1038/s41467-025-59354-5

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