Design of the Inhibitors for Pseudorabies Virus Replication by Reinforcement Learning from HSV‑1 DNA Polymerase Inhibitors

Design of the Inhibitors for Pseudorabies Virus Replication by Reinforcement Learning from HSV‑1 DNA Polymerase Inhibitors

Saved in:

Bibliographic Details
Main Authors:	Lin Wei, Yang Hu, Licheng Bai, Chenxu Xiao, Zhang Liu, Yun You, Keke Wang, Yunyuan Huang, Junfei Zhu, Jun Weng, Wenling Zhou, Han Li, Honghe Zhao, Zhiyong Wu, Meng Mei, Zigong Wei
Format:	Article
Language:	English
Published:	American Chemical Society 2025-01-01
Series:	ACS Omega
Online Access:	https://doi.org/10.1021/acsomega.4c06508
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Communication between DNA polymerases and Replication Protein A within the archaeal replisome
by: Markel Martínez-Carranza, et al.
Published: (2024-12-01)

DNA Polymerase e - More Than a Polymerase
by: Helmut Pospiech, et al.
Published: (2003-01-01)

HSV-1 miR-H6 Inhibits HSV-1 Replication and IL-6 Expression in Human Corneal Epithelial Cells In Vitro
by: Fang Duan, et al.
Published: (2012-01-01)

A replication-incompetent adenoviral vector encoding for HSV-2 gD2 is immunogenic and protective against HSV-2 intravaginal challenge in mice.
by: Elisa Rossetti, et al.
Published: (2024-01-01)

Facts about Wildlife Diseases: Pseudorabies
by: Samantha Wisely
Published: (2014-09-01)

Facts about Wildlife Diseases: Pseudorabies
by: Samantha Wisely
Published: (2014-09-01)

Identification of cepharanthine as an effective inhibitor of African swine fever virus replication
by: Chuanxiang Qi, et al.
Published: (2024-12-01)

Corrigendum to “Verteporfin is an effective inhibitor of HCMV replication” [Virus Research (2024) 1–5/199475]
by: Woo Young Lim, et al.
Published: (2025-01-01)

Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors
by: Romain Pacaud, et al.
Published: (2025-01-01)

Recent advancements in the diverse roles of polymerase-associated proteins in the replication and pathogenesis of Newcastle disease virus
by: Jinghang Zhou, et al.
Published: (2025-01-01)

The DNA Polymerase _-Primase Complex: Multiple Functions and Interactions
by: Marco Muzi-Falconi, et al.
Published: (2003-01-01)

HIV-1 Replication in HIV-Infected Individuals Is Significantly Reduced When Peripheral Blood Mononuclear Cells Are Superinfected with HSV-1
by: Taneth Yamsuwan, et al.
Published: (2012-01-01)

DNA Polymerase: Structural Homology, Conformational Dynamics, and the Effects of Carcinogenic DNA Adducts
by: Richard G. Federley, et al.
Published: (2010-01-01)

An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines
by: Bo Dong, et al.
Published: (2014-01-01)

NS5A replication complex inhibitor daclatasvir in the basis of chronic hepatitis C interferon-free therapy
by: M. V. Mayevskaya, et al.
Published: (2015-12-01)

Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage
by: Robert L. Eoff, et al.
Published: (2010-01-01)

The DNA Replication Stress Hypothesis of Alzheimer’s Disease
by: Yuri B. Yurov, et al.
Published: (2011-01-01)

Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage Response
by: Agnes Malysa, et al.
Published: (2024-12-01)

DNA-mediated self-assembly oxidative damage amplifier combined with copper and MTH1 inhibitor for cancer therapy
by: Cui Ren, et al.
Published: (2025-03-01)

Untreated HSV Leading to Neonatal Death
by: Meghan Sawyer, et al.
Published: (2025-02-01)

Anti-HSV-1 agents: an update
by: Wenwen Lv, et al.
Published: (2025-01-01)

Artificial 64-Residue HIV-1 Enhancer-Binding Peptide Is a Potent Inhibitor of Viral Replication in HIV-1-Infected Cells
by: Mouhssin Oufir, et al.
Published: (2011-01-01)

T7 DNA polymerase treatment improves quantitative sequencing of both double-stranded and single-stranded DNA viruses
by: Billaud, Maud, et al.
Published: (2024-07-01)

RNA polymerase II-mediated rDNA transcription mediates rDNA copy number expansion in Drosophila.
by: George J Watase, et al.
Published: (2024-05-01)

TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA
by: Shigeru Matsuda, et al.
Published: (2025-02-01)

Analysis of the Complete Genome Sequence of a Novel, Pseudorabies Virus Strain Isolated in Southeast Europe
by: Zsolt Csabai, et al.
Published: (2019-01-01)

Determination of Real-Time Polymerase Chain Reaction Uncertainty of Measurement Using Replicate Analysis and a Graphical User Interface with Fieller’s Theorem
by: James Ian Stuart, et al.
Published: (2014-01-01)

Are There Mutator Polymerases?
by: Miguel Garcia-Diaz, et al.
Published: (2003-01-01)

DNA replication initiation drives focal mutagenesis and rearrangements in human cancers
by: Pierre Murat, et al.
Published: (2024-12-01)

PARP4 deficiency enhances sensitivity to ATM inhibitor by impairing DNA damage repair in melanoma
by: Yuehua Li, et al.
Published: (2025-01-01)

Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana
by: Sayo Kashiwagi, et al.
Published: (2010-01-01)

Unveiling the Mechanism of Deprotonation and Proton Transfer of DNA Polymerase Catalysis via Single‐Molecule Conductance
by: Lihua Zhao, et al.
Published: (2025-01-01)

Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells
by: Lei-qing Li, et al.
Published: (2013-01-01)

Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
by: Flavie Coquel, et al.
Published: (2025-01-01)

DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer
by: Xiao Hong Zhao, et al.
Published: (2025-01-01)

A novel high-throughput screen identifies phenazine-1-carboxylic acid as an inhibitor of African swine fever virus replication in primary porcine alveolar macrophages
by: Jing Lan, et al.
Published: (2025-02-01)

Sodium‐Glucose Cotransporter 2 Inhibitors for Mesenchymal–Epithelial Transition Inhibitor‐Induced Edema
by: Takuya Oyakawa, et al.
Published: (2025-01-01)

Assessing hemorrhagic risks in combination therapy: implications of angiogenesis inhibitors and immune checkpoint inhibitors
by: Yuhui Yang, et al.
Published: (2025-02-01)

Purin-6-One Derivatives as Phosphodiesterase-2 Inhibitors
by: Wei Yuan, et al.
Published: (2016-01-01)

SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL
by: E. L. Mishchenko, et al.
Published: (2014-12-01)