Tree shrew as a new animal model for musculoskeletal disorders and aging
Abstract Intervertebral disc degeneration (IDD), osteoarthritis (OA), and osteoporosis (OP) are common musculoskeletal disorders (MSDs) with similar age-related risk factors, representing the leading causes of disability. However, successful therapeutic development and translation have been hampered...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Bone Research |
| Online Access: | https://doi.org/10.1038/s41413-024-00367-z |
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| author | Xiaocui Wei Honghao Li Jingyang Qiu Jianlin Jiao Xiongtian Guo Gaosheng Yin Ping Yang Yi Han Qiongzhi Zhao Hao Zeng Zhi Rao Xuefei Gao Kai Li Pinglin Lai Sheng Zhang Chengliang Yang Di Lu Xiaochun Bai |
| author_facet | Xiaocui Wei Honghao Li Jingyang Qiu Jianlin Jiao Xiongtian Guo Gaosheng Yin Ping Yang Yi Han Qiongzhi Zhao Hao Zeng Zhi Rao Xuefei Gao Kai Li Pinglin Lai Sheng Zhang Chengliang Yang Di Lu Xiaochun Bai |
| author_sort | Xiaocui Wei |
| collection | DOAJ |
| description | Abstract Intervertebral disc degeneration (IDD), osteoarthritis (OA), and osteoporosis (OP) are common musculoskeletal disorders (MSDs) with similar age-related risk factors, representing the leading causes of disability. However, successful therapeutic development and translation have been hampered by the lack of clinically-relevant animal models. In this study, we investigated the potential suitability of the tree shrew, a small mammal with a close genetic relationship to primates, as a new animal model for MSDs. Age-related spontaneous IDD in parallel with a gradual disappearance of notochordal cells were commonly observed in tree shrews upon skeletal maturity with no sex differences, while age-related osteoporotic changes including bone loss in the metaphyses were primarily presented in aged females, similar to observations in humans. Moreover, in the osteochondral defect model, tree shrew cartilage exhibited behavior similar to that of humans, characterized by a more restricted self-healing capacity compared to the rapid spontaneous healing of joint surfaces observed in rats. The induced OA model in tree shrews was highly efficient and reproducible, characterized by gradual deterioration of articular cartilage, recapitulating the human OA phenotype to some degree. Surgery-induced IDD models were successfully established in tree shrews, in which the lumbar spine instability model developed slow progressive disc degeneration with more similarity to the clinical state, whereas the needle puncture model led to the rapid development of IDD with more severe symptoms. Taken together, our findings pave the way for the development of the tree shrew as a new animal model for the study of MSDs and aging. |
| format | Article |
| id | doaj-art-11666b7bbaf243f3ac4f4d5434e8efdb |
| institution | Kabale University |
| issn | 2095-6231 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Bone Research |
| spelling | doaj-art-11666b7bbaf243f3ac4f4d5434e8efdb2025-01-05T12:11:10ZengNature Publishing GroupBone Research2095-62312025-01-0113111310.1038/s41413-024-00367-zTree shrew as a new animal model for musculoskeletal disorders and agingXiaocui Wei0Honghao Li1Jingyang Qiu2Jianlin Jiao3Xiongtian Guo4Gaosheng Yin5Ping Yang6Yi Han7Qiongzhi Zhao8Hao Zeng9Zhi Rao10Xuefei Gao11Kai Li12Pinglin Lai13Sheng Zhang14Chengliang Yang15Di Lu16Xiaochun Bai17State Key Laboratory of Organ Failure Research, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical UniversityGuangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical UniversityState Key Laboratory of Organ Failure Research, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical UniversityYunnan Key Laboratory of Stem Cell and Regenerative Medicine, School of Rehabilitation, Kunming Medical UniversityGuangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical UniversityYunnan Key Laboratory of Stem Cell and Regenerative Medicine, School of Rehabilitation, Kunming Medical UniversityYunnan Key Laboratory of Stem Cell and Regenerative Medicine, School of Rehabilitation, Kunming Medical UniversityYunnan Key Laboratory of Stem Cell and Regenerative Medicine, School of Rehabilitation, Kunming Medical UniversityState Key Laboratory of Organ Failure Research, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical UniversityState Key Laboratory of Organ Failure Research, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical UniversityGuangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical UniversityDepartment of Physiology, School of Basic Medical Sciences, Southern Medical UniversityGuangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical UniversityGuangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical UniversityState Key Laboratory of Organ Failure Research, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical UniversityGuangxi Key Laboratory for Biomedical Material Research, Department of Orthopedics, Affiliated Hospital of Youjiang Medical University for NationalitiesYunnan Key Laboratory of Stem Cell and Regenerative Medicine, School of Rehabilitation, Kunming Medical UniversityState Key Laboratory of Organ Failure Research, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical UniversityAbstract Intervertebral disc degeneration (IDD), osteoarthritis (OA), and osteoporosis (OP) are common musculoskeletal disorders (MSDs) with similar age-related risk factors, representing the leading causes of disability. However, successful therapeutic development and translation have been hampered by the lack of clinically-relevant animal models. In this study, we investigated the potential suitability of the tree shrew, a small mammal with a close genetic relationship to primates, as a new animal model for MSDs. Age-related spontaneous IDD in parallel with a gradual disappearance of notochordal cells were commonly observed in tree shrews upon skeletal maturity with no sex differences, while age-related osteoporotic changes including bone loss in the metaphyses were primarily presented in aged females, similar to observations in humans. Moreover, in the osteochondral defect model, tree shrew cartilage exhibited behavior similar to that of humans, characterized by a more restricted self-healing capacity compared to the rapid spontaneous healing of joint surfaces observed in rats. The induced OA model in tree shrews was highly efficient and reproducible, characterized by gradual deterioration of articular cartilage, recapitulating the human OA phenotype to some degree. Surgery-induced IDD models were successfully established in tree shrews, in which the lumbar spine instability model developed slow progressive disc degeneration with more similarity to the clinical state, whereas the needle puncture model led to the rapid development of IDD with more severe symptoms. Taken together, our findings pave the way for the development of the tree shrew as a new animal model for the study of MSDs and aging.https://doi.org/10.1038/s41413-024-00367-z |
| spellingShingle | Xiaocui Wei Honghao Li Jingyang Qiu Jianlin Jiao Xiongtian Guo Gaosheng Yin Ping Yang Yi Han Qiongzhi Zhao Hao Zeng Zhi Rao Xuefei Gao Kai Li Pinglin Lai Sheng Zhang Chengliang Yang Di Lu Xiaochun Bai Tree shrew as a new animal model for musculoskeletal disorders and aging Bone Research |
| title | Tree shrew as a new animal model for musculoskeletal disorders and aging |
| title_full | Tree shrew as a new animal model for musculoskeletal disorders and aging |
| title_fullStr | Tree shrew as a new animal model for musculoskeletal disorders and aging |
| title_full_unstemmed | Tree shrew as a new animal model for musculoskeletal disorders and aging |
| title_short | Tree shrew as a new animal model for musculoskeletal disorders and aging |
| title_sort | tree shrew as a new animal model for musculoskeletal disorders and aging |
| url | https://doi.org/10.1038/s41413-024-00367-z |
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