Therapy Management of Metastatic Prostate Carcinoma in General Practice
In general, advanced prostate cancer is initially treated with androgen deprivation therapy (ADT). Despite high response rates to this treatment, the response is not durable and most of the patients eventually develop metastatic castration-resistant prostate cancer (mCRPC). The treatment strategies...
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| Format: | Article |
| Language: | English |
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THE HEALTHBOOK COMPANY LTD.
2019-09-01
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| Series: | healthbook TIMES. Oncology Hematology |
| Online Access: | https://doi.org/10.36000/hbT.OH.2019.01.004 |
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| _version_ | 1846126475011424256 |
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| author | Alexander Meisel |
| author_facet | Alexander Meisel |
| author_sort | Alexander Meisel |
| collection | DOAJ |
| description | In general, advanced prostate cancer is initially treated with androgen deprivation therapy (ADT). Despite high response rates to this treatment, the response is not durable and most of the patients eventually develop metastatic castration-resistant prostate cancer (mCRPC). The treatment strategies for mCRPC usually include a combination of different approaches, such as hormone therapy, chemotherapy, or radiation. Here, we discuss the case of a 78-year old patient with advanced prostate cancer who developed mCRPC after 4 years of continuous therapy with ADT. The patient was subsequently treated with analgesic radiotherapy, followed by chemotherapy, including docetaxel and cabazitaxel. The patient responded well to the treatment, with acceptable treatment-related toxicity. Three years later, however, the disease progressed, and the patient received anti-hormonal therapy with enzalutamide. In conclusion, this case report discusses the different therapy selections and outcomes. Finally, a literature overview offers a comprehensive insight into the current systemic therapies for mCRPC. |
| format | Article |
| id | doaj-art-114b3c0e6a4d401f9719072360de9801 |
| institution | Kabale University |
| issn | 2673-2106 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | THE HEALTHBOOK COMPANY LTD. |
| record_format | Article |
| series | healthbook TIMES. Oncology Hematology |
| spelling | doaj-art-114b3c0e6a4d401f9719072360de98012024-12-12T17:11:18ZengTHE HEALTHBOOK COMPANY LTD.healthbook TIMES. Oncology Hematology2673-21062019-09-0111Therapy Management of Metastatic Prostate Carcinoma in General PracticeAlexander MeiselIn general, advanced prostate cancer is initially treated with androgen deprivation therapy (ADT). Despite high response rates to this treatment, the response is not durable and most of the patients eventually develop metastatic castration-resistant prostate cancer (mCRPC). The treatment strategies for mCRPC usually include a combination of different approaches, such as hormone therapy, chemotherapy, or radiation. Here, we discuss the case of a 78-year old patient with advanced prostate cancer who developed mCRPC after 4 years of continuous therapy with ADT. The patient was subsequently treated with analgesic radiotherapy, followed by chemotherapy, including docetaxel and cabazitaxel. The patient responded well to the treatment, with acceptable treatment-related toxicity. Three years later, however, the disease progressed, and the patient received anti-hormonal therapy with enzalutamide. In conclusion, this case report discusses the different therapy selections and outcomes. Finally, a literature overview offers a comprehensive insight into the current systemic therapies for mCRPC.https://doi.org/10.36000/hbT.OH.2019.01.004 |
| spellingShingle | Alexander Meisel Therapy Management of Metastatic Prostate Carcinoma in General Practice healthbook TIMES. Oncology Hematology |
| title | Therapy Management of Metastatic Prostate Carcinoma in General Practice |
| title_full | Therapy Management of Metastatic Prostate Carcinoma in General Practice |
| title_fullStr | Therapy Management of Metastatic Prostate Carcinoma in General Practice |
| title_full_unstemmed | Therapy Management of Metastatic Prostate Carcinoma in General Practice |
| title_short | Therapy Management of Metastatic Prostate Carcinoma in General Practice |
| title_sort | therapy management of metastatic prostate carcinoma in general practice |
| url | https://doi.org/10.36000/hbT.OH.2019.01.004 |
| work_keys_str_mv | AT alexandermeisel therapymanagementofmetastaticprostatecarcinomaingeneralpractice |