Optical coherence tomography for examining retina in patients with HIV/TB coinfection
<p> <b>E.A. Burylova, A.P. Demin, S.N. Skornyakov, E.V. Sabadash</b> </p> <p> <b>Ural Scientific Research Institute of Phtysiopulmonology – Branch of the National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Ekaterinburg, Russian Feder...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Prime-Media
2022-02-01
|
| Series: | РМЖ "Клиническая офтальмология" |
| Online Access: | http://clinopht.com/upload/iblock/304/3043c73376bd8db836db1b8cc0ca5bbd.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841526854224183296 |
|---|---|
| author | E.A. Burylova A.P. Demin S.N. Skornyakov E.V. Sabadash |
| author_facet | E.A. Burylova A.P. Demin S.N. Skornyakov E.V. Sabadash |
| author_sort | E.A. Burylova |
| collection | DOAJ |
| description | <p>
<b>E.A. Burylova, A.P. Demin, S.N. Skornyakov, E.V. Sabadash</b>
</p>
<p>
<b>Ural Scientific Research Institute of Phtysiopulmonology – Branch of the National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Ekaterinburg, Russian Federation</b>
</p>
<p>
<i><b>Aim</b>: to assess the retina (including peripapillary retinal nerve fiber layer/RNFL and retinal vessel diameter) in patients with tuberculosis (TB) or HIV/TB coinfection in the lack of abnormalities detected by standard eye exam using optical coherence tomography (OCT).</i>
</p>
<p>
<i><b>Patients and Methods:</b> all patients were divided into three groups. Group 1 (n=19) included patients with HIV/TB coinfection. Group 2 (n=18) included patients with pulmonary and extrapulmonary TB. Group 3 (n=20) included healthy volunteers (controls). All patients underwent standard eye exam and OCT (iVue-100 v3.2, Optovue, USA) to measure peripapillary RNFL thickness, central macular thickness, and the first-order retinal vessel diameter (eight vessels).</i>
</p>
<p>
<i><b>Results</b>: OCT demonstrated greater peripapillary RNFL thickness in the nasal sector (by 13.4–18.3%) and central macular thickness (by 4.0–7.5%), narrowing of retinal arteries, and enlargement of veins (predominantly temporal). These patterns may illustrate retinal microcirculation in the setting of a pathological condition (HIV/TB, including highly active antiretroviral therapy [HAART]) and be a harbinger of further abnormalities of ocular structures and central nervous system.</i>
</p>
<p>
<i><b>Conclusion</b>: OCT identifies changes in vessel diameter, central macular thickness, and peripapillary RFNL thickness before visual disturbances in preclinical eye changes in patients with HIV/TB coinfection.</i>
</p>
<p>
<i><b>Keywords</b>: HIV, tuberculosis, optical coherence tomography, calipermetry, retina.</i>
</p>
<p>
<i><b>For citation: </b>Burylova E.A., Demin A.P., Skornyakov S.N., Sabadash E.V. Optical coherence tomography for examining retina in patients with HIV/TB coinfection. Russian Journal of Clinical Ophthalmology. 2022;22(1):23–29 (in Russ.). DOI: 10.32364/2311-7729-2022-22-1-23-29.</i>
</p>
<i><br>
</i><br> |
| format | Article |
| id | doaj-art-110bbf1975d54eb2a418d2cba7b13c5c |
| institution | Kabale University |
| issn | 2311-7729 2619-1571 |
| language | Russian |
| publishDate | 2022-02-01 |
| publisher | Prime-Media |
| record_format | Article |
| series | РМЖ "Клиническая офтальмология" |
| spelling | doaj-art-110bbf1975d54eb2a418d2cba7b13c5c2025-01-16T09:39:37ZrusPrime-MediaРМЖ "Клиническая офтальмология"2311-77292619-15712022-02-0122131421Optical coherence tomography for examining retina in patients with HIV/TB coinfectionE.A. Burylova0A.P. Demin1S.N. Skornyakov2E.V. Sabadash3Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399<p> <b>E.A. Burylova, A.P. Demin, S.N. Skornyakov, E.V. Sabadash</b> </p> <p> <b>Ural Scientific Research Institute of Phtysiopulmonology – Branch of the National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Ekaterinburg, Russian Federation</b> </p> <p> <i><b>Aim</b>: to assess the retina (including peripapillary retinal nerve fiber layer/RNFL and retinal vessel diameter) in patients with tuberculosis (TB) or HIV/TB coinfection in the lack of abnormalities detected by standard eye exam using optical coherence tomography (OCT).</i> </p> <p> <i><b>Patients and Methods:</b> all patients were divided into three groups. Group 1 (n=19) included patients with HIV/TB coinfection. Group 2 (n=18) included patients with pulmonary and extrapulmonary TB. Group 3 (n=20) included healthy volunteers (controls). All patients underwent standard eye exam and OCT (iVue-100 v3.2, Optovue, USA) to measure peripapillary RNFL thickness, central macular thickness, and the first-order retinal vessel diameter (eight vessels).</i> </p> <p> <i><b>Results</b>: OCT demonstrated greater peripapillary RNFL thickness in the nasal sector (by 13.4–18.3%) and central macular thickness (by 4.0–7.5%), narrowing of retinal arteries, and enlargement of veins (predominantly temporal). These patterns may illustrate retinal microcirculation in the setting of a pathological condition (HIV/TB, including highly active antiretroviral therapy [HAART]) and be a harbinger of further abnormalities of ocular structures and central nervous system.</i> </p> <p> <i><b>Conclusion</b>: OCT identifies changes in vessel diameter, central macular thickness, and peripapillary RFNL thickness before visual disturbances in preclinical eye changes in patients with HIV/TB coinfection.</i> </p> <p> <i><b>Keywords</b>: HIV, tuberculosis, optical coherence tomography, calipermetry, retina.</i> </p> <p> <i><b>For citation: </b>Burylova E.A., Demin A.P., Skornyakov S.N., Sabadash E.V. Optical coherence tomography for examining retina in patients with HIV/TB coinfection. Russian Journal of Clinical Ophthalmology. 2022;22(1):23–29 (in Russ.). DOI: 10.32364/2311-7729-2022-22-1-23-29.</i> </p> <i><br> </i><br>http://clinopht.com/upload/iblock/304/3043c73376bd8db836db1b8cc0ca5bbd.pdf |
| spellingShingle | E.A. Burylova A.P. Demin S.N. Skornyakov E.V. Sabadash Optical coherence tomography for examining retina in patients with HIV/TB coinfection РМЖ "Клиническая офтальмология" |
| title | Optical coherence tomography for examining retina in patients with HIV/TB coinfection |
| title_full | Optical coherence tomography for examining retina in patients with HIV/TB coinfection |
| title_fullStr | Optical coherence tomography for examining retina in patients with HIV/TB coinfection |
| title_full_unstemmed | Optical coherence tomography for examining retina in patients with HIV/TB coinfection |
| title_short | Optical coherence tomography for examining retina in patients with HIV/TB coinfection |
| title_sort | optical coherence tomography for examining retina in patients with hiv tb coinfection |
| url | http://clinopht.com/upload/iblock/304/3043c73376bd8db836db1b8cc0ca5bbd.pdf |
| work_keys_str_mv | AT eaburylova opticalcoherencetomographyforexaminingretinainpatientswithhivtbcoinfection AT apdemin opticalcoherencetomographyforexaminingretinainpatientswithhivtbcoinfection AT snskornyakov opticalcoherencetomographyforexaminingretinainpatientswithhivtbcoinfection AT evsabadash opticalcoherencetomographyforexaminingretinainpatientswithhivtbcoinfection |