From Cellular to Metabolic: Advances in Imaging of Inherited Retinal Diseases
<b>Background</b>: Inherited retinal diseases (IRDs) are a genetically complex group of disorders, usually resulting in progressive vision loss due to retinal degeneration. Traditional imaging methods help in structural assessments, but limitations exist in early functional cellular-leve...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/1/28 |
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| author | Deepika C. Parameswarappa Ashwini Kulkarni Niroj Kumar Sahoo Srikanta Kumar Padhy Sumit Randhir Singh Elise Héon Jay Chhablani |
| author_facet | Deepika C. Parameswarappa Ashwini Kulkarni Niroj Kumar Sahoo Srikanta Kumar Padhy Sumit Randhir Singh Elise Héon Jay Chhablani |
| author_sort | Deepika C. Parameswarappa |
| collection | DOAJ |
| description | <b>Background</b>: Inherited retinal diseases (IRDs) are a genetically complex group of disorders, usually resulting in progressive vision loss due to retinal degeneration. Traditional imaging methods help in structural assessments, but limitations exist in early functional cellular-level detection that are crucial for guiding new therapies. <b>Methods</b>: This review includes a systematic search of PubMed and Google Scholar for studies on advanced imaging techniques for IRDs. <b>Results</b>: Key modalities covered are adaptive optics, fluorescence lifetime imaging ophthalmoscopy, polarization-sensitive optical coherence tomography, optoretinography, mitochondrial imaging, flavoprotein fluorescence imaging, and retinal oximetry. Each imaging method covers its principles, acquisition techniques, data from healthy eyes, applications in IRDs with specific examples, and current challenges and future directions. <b>Conclusions</b>: Emerging technologies, including adaptive optics and metabolic imaging, offer promising potential for cellular-level imaging and functional correlation in IRDs, allowing for earlier intervention and improved therapeutic targeting. Their integration into clinical practice may significantly improve IRD management and patient outcomes. |
| format | Article |
| id | doaj-art-10f4d1d8d1f64314a34725eb48a56cb4 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-10f4d1d8d1f64314a34725eb48a56cb42025-01-10T13:16:30ZengMDPI AGDiagnostics2075-44182024-12-011512810.3390/diagnostics15010028From Cellular to Metabolic: Advances in Imaging of Inherited Retinal DiseasesDeepika C. Parameswarappa0Ashwini Kulkarni1Niroj Kumar Sahoo2Srikanta Kumar Padhy3Sumit Randhir Singh4Elise Héon5Jay Chhablani6Ophthalmology and Vision Sciences, Hospital for Sick Children, University of Toronto, Toronto, ON M5S 1E8, CanadaAnant Bajaj Retina Institute, LV Prasad Eye Institute, Vijayawada 521134, IndiaAnant Bajaj Retina Institute, LV Prasad Eye Institute, Vijayawada 521134, IndiaAnant Bajaj Retina Institute, LV Prasad Eye Institute, Bhubaneswar 751024, IndiaAkhand Jyoti Eye Hospital, Bihar 841219, IndiaOphthalmology and Vision Sciences, Hospital for Sick Children, University of Toronto, Toronto, ON M5S 1E8, CanadaUPMC Eye Centre and Choroidal Analysis and Research (CAR) Lab, University of Pittsburgh, Pittsburgh, PA 15213, USA<b>Background</b>: Inherited retinal diseases (IRDs) are a genetically complex group of disorders, usually resulting in progressive vision loss due to retinal degeneration. Traditional imaging methods help in structural assessments, but limitations exist in early functional cellular-level detection that are crucial for guiding new therapies. <b>Methods</b>: This review includes a systematic search of PubMed and Google Scholar for studies on advanced imaging techniques for IRDs. <b>Results</b>: Key modalities covered are adaptive optics, fluorescence lifetime imaging ophthalmoscopy, polarization-sensitive optical coherence tomography, optoretinography, mitochondrial imaging, flavoprotein fluorescence imaging, and retinal oximetry. Each imaging method covers its principles, acquisition techniques, data from healthy eyes, applications in IRDs with specific examples, and current challenges and future directions. <b>Conclusions</b>: Emerging technologies, including adaptive optics and metabolic imaging, offer promising potential for cellular-level imaging and functional correlation in IRDs, allowing for earlier intervention and improved therapeutic targeting. Their integration into clinical practice may significantly improve IRD management and patient outcomes.https://www.mdpi.com/2075-4418/15/1/28inherited retinal diseasescellular imagingadaptive opticsfluorescence lifetime imaging ophthalmoscopyPS-OCTmetabolic imaging |
| spellingShingle | Deepika C. Parameswarappa Ashwini Kulkarni Niroj Kumar Sahoo Srikanta Kumar Padhy Sumit Randhir Singh Elise Héon Jay Chhablani From Cellular to Metabolic: Advances in Imaging of Inherited Retinal Diseases Diagnostics inherited retinal diseases cellular imaging adaptive optics fluorescence lifetime imaging ophthalmoscopy PS-OCT metabolic imaging |
| title | From Cellular to Metabolic: Advances in Imaging of Inherited Retinal Diseases |
| title_full | From Cellular to Metabolic: Advances in Imaging of Inherited Retinal Diseases |
| title_fullStr | From Cellular to Metabolic: Advances in Imaging of Inherited Retinal Diseases |
| title_full_unstemmed | From Cellular to Metabolic: Advances in Imaging of Inherited Retinal Diseases |
| title_short | From Cellular to Metabolic: Advances in Imaging of Inherited Retinal Diseases |
| title_sort | from cellular to metabolic advances in imaging of inherited retinal diseases |
| topic | inherited retinal diseases cellular imaging adaptive optics fluorescence lifetime imaging ophthalmoscopy PS-OCT metabolic imaging |
| url | https://www.mdpi.com/2075-4418/15/1/28 |
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