Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease
Metabolic dysfunction–associated steatotic liver disease (MASLD) is a multisystemic disease with a multifactorial pathogenesis involving dietary, environmental, and genetic factors. Previous mouse models suggested that circadian misalignment may additionally influence its development as it influence...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Network Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnetp.2024.1458665/full |
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| author | Sofia Schaeffer Sofia Schaeffer Andrijana Bogdanovic Talitha Hildebrandt Emilio Flint Anne Geng Sylvia Pecenko Paul Lussier Michael A. Strumberger Martin Meyer Jakob Weber Markus H. Heim Markus H. Heim Christian Cajochen Christine Bernsmeier Christine Bernsmeier |
| author_facet | Sofia Schaeffer Sofia Schaeffer Andrijana Bogdanovic Talitha Hildebrandt Emilio Flint Anne Geng Sylvia Pecenko Paul Lussier Michael A. Strumberger Martin Meyer Jakob Weber Markus H. Heim Markus H. Heim Christian Cajochen Christine Bernsmeier Christine Bernsmeier |
| author_sort | Sofia Schaeffer |
| collection | DOAJ |
| description | Metabolic dysfunction–associated steatotic liver disease (MASLD) is a multisystemic disease with a multifactorial pathogenesis involving dietary, environmental, and genetic factors. Previous mouse models suggested that circadian misalignment may additionally influence its development as it influences metabolism in diverse organs including the liver. Further, data from sleep questionnaires proved sleep-wake disruption in patients with MASLD. We objectively assessed sleep-wake rhythms in patients with biopsy-proven MASLD (n = 35) and healthy controls (HC, n = 16) using actigraphy 24/7 for 4 weeks. With the aim to re-align sleep rhythms a single standardized sleep hygiene education session was performed after 2 weeks. Actigraphy data revealed that MASLD patients had more awakenings per night (MASLD vs. HC 8.5 vs. 5.5, p = 0.0036), longer wakefulness after sleep onset (MASLD vs. HC 45.4 min vs. 21.3 min, p = 0.0004), and decreased sleep efficiency (MASLD vs. HC 86.5% vs. 92.8%, p = 0.0008) compared with HC despite comparable sleep duration. Patients with MASLD self-reported shorter sleep duration (MASLD vs. HC 6 h vs. 6 h 45 min, p = 0.01) and prolonged sleep latency contributing to poorer sleep quality. Standardized sleep hygiene education did not produce significant changes in sleep parameters. Our findings indicate fragmented nocturnal sleep in patients with MASLD, characterized by increased wakefulness and reduced sleep efficiency, perceived subjectively as shortened sleep duration and delayed onset. A single sleep hygiene education session did not improve sleep parameters. |
| format | Article |
| id | doaj-art-10f0f855da5b464abb5eae57c42ab0a6 |
| institution | Kabale University |
| issn | 2674-0109 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Network Physiology |
| spelling | doaj-art-10f0f855da5b464abb5eae57c42ab0a62024-12-04T04:23:07ZengFrontiers Media S.A.Frontiers in Network Physiology2674-01092024-12-01410.3389/fnetp.2024.14586651458665Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver diseaseSofia Schaeffer0Sofia Schaeffer1Andrijana Bogdanovic2Talitha Hildebrandt3Emilio Flint4Anne Geng5Sylvia Pecenko6Paul Lussier7Michael A. Strumberger8Martin Meyer9Jakob Weber10Markus H. Heim11Markus H. Heim12Christian Cajochen13Christine Bernsmeier14Christine Bernsmeier15Department of Biomedicine and Department of Clinical Research, University of Basel, Basel, SwitzerlandUniversity Centre for Gastrointestinal and Liver Diseases, Basel, SwitzerlandDepartment of Biomedicine and Department of Clinical Research, University of Basel, Basel, SwitzerlandDepartment of Biomedicine and Department of Clinical Research, University of Basel, Basel, SwitzerlandDepartment of Biomedicine and Department of Clinical Research, University of Basel, Basel, SwitzerlandDepartment of Biomedicine and Department of Clinical Research, University of Basel, Basel, SwitzerlandDepartment of Biomedicine and Department of Clinical Research, University of Basel, Basel, SwitzerlandDepartment of Biomedicine and Department of Clinical Research, University of Basel, Basel, SwitzerlandCentre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, SwitzerlandCentre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, SwitzerlandNovoLytiX GmbH, Witterswil, SwitzerlandDepartment of Biomedicine and Department of Clinical Research, University of Basel, Basel, SwitzerlandUniversity Centre for Gastrointestinal and Liver Diseases, Basel, SwitzerlandCentre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, SwitzerlandDepartment of Biomedicine and Department of Clinical Research, University of Basel, Basel, SwitzerlandUniversity Centre for Gastrointestinal and Liver Diseases, Basel, SwitzerlandMetabolic dysfunction–associated steatotic liver disease (MASLD) is a multisystemic disease with a multifactorial pathogenesis involving dietary, environmental, and genetic factors. Previous mouse models suggested that circadian misalignment may additionally influence its development as it influences metabolism in diverse organs including the liver. Further, data from sleep questionnaires proved sleep-wake disruption in patients with MASLD. We objectively assessed sleep-wake rhythms in patients with biopsy-proven MASLD (n = 35) and healthy controls (HC, n = 16) using actigraphy 24/7 for 4 weeks. With the aim to re-align sleep rhythms a single standardized sleep hygiene education session was performed after 2 weeks. Actigraphy data revealed that MASLD patients had more awakenings per night (MASLD vs. HC 8.5 vs. 5.5, p = 0.0036), longer wakefulness after sleep onset (MASLD vs. HC 45.4 min vs. 21.3 min, p = 0.0004), and decreased sleep efficiency (MASLD vs. HC 86.5% vs. 92.8%, p = 0.0008) compared with HC despite comparable sleep duration. Patients with MASLD self-reported shorter sleep duration (MASLD vs. HC 6 h vs. 6 h 45 min, p = 0.01) and prolonged sleep latency contributing to poorer sleep quality. Standardized sleep hygiene education did not produce significant changes in sleep parameters. Our findings indicate fragmented nocturnal sleep in patients with MASLD, characterized by increased wakefulness and reduced sleep efficiency, perceived subjectively as shortened sleep duration and delayed onset. A single sleep hygiene education session did not improve sleep parameters.https://www.frontiersin.org/articles/10.3389/fnetp.2024.1458665/fullMASLDcircadian misalignmentcircadian rhythmactigraphysleep hygiene education |
| spellingShingle | Sofia Schaeffer Sofia Schaeffer Andrijana Bogdanovic Talitha Hildebrandt Emilio Flint Anne Geng Sylvia Pecenko Paul Lussier Michael A. Strumberger Martin Meyer Jakob Weber Markus H. Heim Markus H. Heim Christian Cajochen Christine Bernsmeier Christine Bernsmeier Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease Frontiers in Network Physiology MASLD circadian misalignment circadian rhythm actigraphy sleep hygiene education |
| title | Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease |
| title_full | Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease |
| title_fullStr | Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease |
| title_full_unstemmed | Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease |
| title_short | Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease |
| title_sort | significant nocturnal wakefulness after sleep onset in metabolic dysfunction associated steatotic liver disease |
| topic | MASLD circadian misalignment circadian rhythm actigraphy sleep hygiene education |
| url | https://www.frontiersin.org/articles/10.3389/fnetp.2024.1458665/full |
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