A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs
IntroductionElderly dogs often suffer from chronic diseases, in part attributed to immunosenescence, characterized by reduced blood CD4+ T cells (helper T cells) and elevation in the CD8+ T cells subset (cytotoxic T cells). Studies conducted in adult dogs suggested that supplementing short chain fru...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1392985/full |
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| author | Wendy A. Wambacq Emmanuelle Apper Cindy Le Bourgot Florence Barbe Yang Lyu Michael Pelst Bart J. G. Broeckx Bert Devriendt Eric Cox Myriam Hesta |
| author_facet | Wendy A. Wambacq Emmanuelle Apper Cindy Le Bourgot Florence Barbe Yang Lyu Michael Pelst Bart J. G. Broeckx Bert Devriendt Eric Cox Myriam Hesta |
| author_sort | Wendy A. Wambacq |
| collection | DOAJ |
| description | IntroductionElderly dogs often suffer from chronic diseases, in part attributed to immunosenescence, characterized by reduced blood CD4+ T cells (helper T cells) and elevation in the CD8+ T cells subset (cytotoxic T cells). Studies conducted in adult dogs suggested that supplementing short chain fructo-oligosaccharides (scFOS) or postbiotics derived from yeasts may positively influence the immune response. The aim of the current study was to investigate whether dietary supplementation with a combination of scFOS with a new yeast postbiotic (Profeed ADVANCED® called scFOS+) could have a positive influence on the immune status of senior dogs subjected to an immune challenge (Lyme disease vaccination).MethodsTo this end, 22 healthy senior client-owned dogs were divided into two groups: one group received a placebo diet without scFOS+ and the other group the basal diet supplemented with 1.1% scFOS+. In order to assess immune function, complete blood count, serum acute phase proteins, immunoglobulins, cytokines, T-cell subsets and antibody secreting cells were analyzed. Furthermore, faecal score and pH were recorded.Results and discussionDogs fed the scFOS+ supplement had decreased total serum IgA concentrations (p < 0.01), which might suggest a more local IgA response in agreement with what was previously found when adult dogs were supplemented with β-1, 3/1, 6-glucan, a yeast-based product. More importantly, the present study demonstrated that feeding 1.1% scFOS+ to healthy senior dogs increased the CD4+:CD8+ T-cell (Helper:Cytotoxic T cell) ratio (p < 0.001) during and after vaccination against Lyme disease. Combining scFOS and yeast-derived postbiotics in the diet can therefore counter certain characteristics of T-cell immunosenescence in dogs. |
| format | Article |
| id | doaj-art-10e34e13330d4ad1b93670272568afdf |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-10e34e13330d4ad1b93670272568afdf2024-11-20T15:06:21ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692024-11-011110.3389/fvets.2024.13929851392985A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogsWendy A. Wambacq0Emmanuelle Apper1Cindy Le Bourgot2Florence Barbe3Yang Lyu4Michael Pelst5Bart J. G. Broeckx6Bert Devriendt7Eric Cox8Myriam Hesta9Equine and Companion Animal Nutrition, Department of Morphology, Imaging, Orthopedics, Rehabilitation and Nutrition, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumLallemand Animal Nutrition, Blagnac, FranceScientific and Regulatory Affairs Department, Tereos, Moussy-le-Vieux, FranceLallemand Animal Nutrition, Blagnac, FranceEquine and Companion Animal Nutrition, Department of Morphology, Imaging, Orthopedics, Rehabilitation and Nutrition, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumLaboratory of Immunology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumDepartment of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumLaboratory of Immunology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumLaboratory of Immunology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumEquine and Companion Animal Nutrition, Department of Morphology, Imaging, Orthopedics, Rehabilitation and Nutrition, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumIntroductionElderly dogs often suffer from chronic diseases, in part attributed to immunosenescence, characterized by reduced blood CD4+ T cells (helper T cells) and elevation in the CD8+ T cells subset (cytotoxic T cells). Studies conducted in adult dogs suggested that supplementing short chain fructo-oligosaccharides (scFOS) or postbiotics derived from yeasts may positively influence the immune response. The aim of the current study was to investigate whether dietary supplementation with a combination of scFOS with a new yeast postbiotic (Profeed ADVANCED® called scFOS+) could have a positive influence on the immune status of senior dogs subjected to an immune challenge (Lyme disease vaccination).MethodsTo this end, 22 healthy senior client-owned dogs were divided into two groups: one group received a placebo diet without scFOS+ and the other group the basal diet supplemented with 1.1% scFOS+. In order to assess immune function, complete blood count, serum acute phase proteins, immunoglobulins, cytokines, T-cell subsets and antibody secreting cells were analyzed. Furthermore, faecal score and pH were recorded.Results and discussionDogs fed the scFOS+ supplement had decreased total serum IgA concentrations (p < 0.01), which might suggest a more local IgA response in agreement with what was previously found when adult dogs were supplemented with β-1, 3/1, 6-glucan, a yeast-based product. More importantly, the present study demonstrated that feeding 1.1% scFOS+ to healthy senior dogs increased the CD4+:CD8+ T-cell (Helper:Cytotoxic T cell) ratio (p < 0.001) during and after vaccination against Lyme disease. Combining scFOS and yeast-derived postbiotics in the diet can therefore counter certain characteristics of T-cell immunosenescence in dogs.https://www.frontiersin.org/articles/10.3389/fvets.2024.1392985/fullscFOSprebioticpostbioticimmunosenescenceelderly dogvaccine |
| spellingShingle | Wendy A. Wambacq Emmanuelle Apper Cindy Le Bourgot Florence Barbe Yang Lyu Michael Pelst Bart J. G. Broeckx Bert Devriendt Eric Cox Myriam Hesta A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs Frontiers in Veterinary Science scFOS prebiotic postbiotic immunosenescence elderly dog vaccine |
| title | A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs |
| title_full | A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs |
| title_fullStr | A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs |
| title_full_unstemmed | A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs |
| title_short | A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs |
| title_sort | new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs |
| topic | scFOS prebiotic postbiotic immunosenescence elderly dog vaccine |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1392985/full |
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