ACTN3 GENE POLYMORPHISM AND FACTORS ASSOCIATED WITH FUNCTIONAL PERFORMANCE IN ELDERLY WOMEN ASSISTED IN PRIMARY HEALTH CARE
ABSTRACT Objective: To analyze potential influences of the R/X genetic polymorphism of the ACTN3 gene, as well as of anthropometric and metabolic characteristics on the functional performance of elderly women assisted in primary health care. Method: One hundred and forty-one elderly women were asses...
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Universidade Estadual de Maringá
2022-12-01
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| Series: | Journal of Physical Education |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2448-24552022000100250&tlng=en |
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| author | Leandro César Teixeira Machado Mateus Medeiros Leite Marina Morato Stival Yuri Gustavo de Sousa Barbalho Filipe Dinato de Lima Luciano Ramos de Lima Alessandro de Oliveira Silva Izabel Cristina Rodrigues da Silva Silvana Schwerz Funghetto |
| author_facet | Leandro César Teixeira Machado Mateus Medeiros Leite Marina Morato Stival Yuri Gustavo de Sousa Barbalho Filipe Dinato de Lima Luciano Ramos de Lima Alessandro de Oliveira Silva Izabel Cristina Rodrigues da Silva Silvana Schwerz Funghetto |
| author_sort | Leandro César Teixeira Machado |
| collection | DOAJ |
| description | ABSTRACT Objective: To analyze potential influences of the R/X genetic polymorphism of the ACTN3 gene, as well as of anthropometric and metabolic characteristics on the functional performance of elderly women assisted in primary health care. Method: One hundred and forty-one elderly women were assessed in terms of anthropometric, metabolic and functional aspects, in addition to clinical, cognitive and demographic characteristics. Allele and genotype frequencies of ACTN3 gene polymorphism were determined. Results: 141 elderly women (68.30 ± 6.18 years) were evaluated. No significant differences (p > 0.05) were observed between the RR and RX/XX genotypes in the elderly women’s functional performance, anthropometric or metabolic characteristics. The TUG test completion time showed positive correlations with age, body mass index, waist circumference, and fat percentage (s = 0.315; p < 0.001; s = 0.238; p = 0.005; s = 0.174; p = 0.039; s = 0.207; p = 0.014), respectively. Negative correlations were found between the TUG test with absolute handgrip strength (s = - 0.314; p < 0.001) and relative handgrip strength (s = - 0.380; p < 0.001). Conclusion: In our study, there were no influences from ACTN3 gene polymorphisms on the functional performance of the elderly women, which is influenced by other factors. |
| format | Article |
| id | doaj-art-10d49a742afa4e75b2094fb42a846b95 |
| institution | Kabale University |
| issn | 2448-2455 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Universidade Estadual de Maringá |
| record_format | Article |
| series | Journal of Physical Education |
| spelling | doaj-art-10d49a742afa4e75b2094fb42a846b952024-12-14T14:30:06ZengUniversidade Estadual de MaringáJournal of Physical Education2448-24552022-12-013310.4025/jphyseduc.v33i1.3351ACTN3 GENE POLYMORPHISM AND FACTORS ASSOCIATED WITH FUNCTIONAL PERFORMANCE IN ELDERLY WOMEN ASSISTED IN PRIMARY HEALTH CARELeandro César Teixeira Machadohttps://orcid.org/0000-0002-7003-6442Mateus Medeiros Leitehttps://orcid.org/0000-0002-0438-3833Marina Morato Stivalhttps://orcid.org/0000-0001-6830-4914Yuri Gustavo de Sousa Barbalhohttps://orcid.org/0000-0002-5584-998XFilipe Dinato de Limahttps://orcid.org/0000-0001-5748-7540Luciano Ramos de Limahttps://orcid.org/0000-0002-2709-6335Alessandro de Oliveira Silvahttps://orcid.org/0000-0003-3513-7034Izabel Cristina Rodrigues da Silvahttps://orcid.org/0000-0002-6836-3583Silvana Schwerz Funghettohttps://orcid.org/0000-0002-9332-9029ABSTRACT Objective: To analyze potential influences of the R/X genetic polymorphism of the ACTN3 gene, as well as of anthropometric and metabolic characteristics on the functional performance of elderly women assisted in primary health care. Method: One hundred and forty-one elderly women were assessed in terms of anthropometric, metabolic and functional aspects, in addition to clinical, cognitive and demographic characteristics. Allele and genotype frequencies of ACTN3 gene polymorphism were determined. Results: 141 elderly women (68.30 ± 6.18 years) were evaluated. No significant differences (p > 0.05) were observed between the RR and RX/XX genotypes in the elderly women’s functional performance, anthropometric or metabolic characteristics. The TUG test completion time showed positive correlations with age, body mass index, waist circumference, and fat percentage (s = 0.315; p < 0.001; s = 0.238; p = 0.005; s = 0.174; p = 0.039; s = 0.207; p = 0.014), respectively. Negative correlations were found between the TUG test with absolute handgrip strength (s = - 0.314; p < 0.001) and relative handgrip strength (s = - 0.380; p < 0.001). Conclusion: In our study, there were no influences from ACTN3 gene polymorphisms on the functional performance of the elderly women, which is influenced by other factors.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2448-24552022000100250&tlng=enFunctional performanceGenetic variationAgingMuscle strength |
| spellingShingle | Leandro César Teixeira Machado Mateus Medeiros Leite Marina Morato Stival Yuri Gustavo de Sousa Barbalho Filipe Dinato de Lima Luciano Ramos de Lima Alessandro de Oliveira Silva Izabel Cristina Rodrigues da Silva Silvana Schwerz Funghetto ACTN3 GENE POLYMORPHISM AND FACTORS ASSOCIATED WITH FUNCTIONAL PERFORMANCE IN ELDERLY WOMEN ASSISTED IN PRIMARY HEALTH CARE Journal of Physical Education Functional performance Genetic variation Aging Muscle strength |
| title | ACTN3 GENE POLYMORPHISM AND FACTORS ASSOCIATED WITH FUNCTIONAL PERFORMANCE IN ELDERLY WOMEN ASSISTED IN PRIMARY HEALTH CARE |
| title_full | ACTN3 GENE POLYMORPHISM AND FACTORS ASSOCIATED WITH FUNCTIONAL PERFORMANCE IN ELDERLY WOMEN ASSISTED IN PRIMARY HEALTH CARE |
| title_fullStr | ACTN3 GENE POLYMORPHISM AND FACTORS ASSOCIATED WITH FUNCTIONAL PERFORMANCE IN ELDERLY WOMEN ASSISTED IN PRIMARY HEALTH CARE |
| title_full_unstemmed | ACTN3 GENE POLYMORPHISM AND FACTORS ASSOCIATED WITH FUNCTIONAL PERFORMANCE IN ELDERLY WOMEN ASSISTED IN PRIMARY HEALTH CARE |
| title_short | ACTN3 GENE POLYMORPHISM AND FACTORS ASSOCIATED WITH FUNCTIONAL PERFORMANCE IN ELDERLY WOMEN ASSISTED IN PRIMARY HEALTH CARE |
| title_sort | actn3 gene polymorphism and factors associated with functional performance in elderly women assisted in primary health care |
| topic | Functional performance Genetic variation Aging Muscle strength |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2448-24552022000100250&tlng=en |
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