Surfactant-derived protein type B: a new biomarker linked to respiratory failure and lung damage in mild to moderate SARS-CoV-2 pneumonia
Background The COVID-19 pandemic has led to significant concern due to its impact on human health, particularly through pneumonia-induced lung damage. Surfactant proteins A and D (SP-A and SP-D) are implicated in COVID-19 lung damage, but the role of surfactant protein B (SP-B) remains unclear. Meth...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2024-11-01
|
| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/10/6/00301-2024.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841537070126858240 |
|---|---|
| author | Massimo Mapelli Elisabetta Salvioni Irene Mattavelli Cristina Banfi Stefania Ghilardi Arianna Greco Maria Luisa Biondi Sara Rovai Elisabetta Mancini Sergio Harari Piergiuseppe Agostoni |
| author_facet | Massimo Mapelli Elisabetta Salvioni Irene Mattavelli Cristina Banfi Stefania Ghilardi Arianna Greco Maria Luisa Biondi Sara Rovai Elisabetta Mancini Sergio Harari Piergiuseppe Agostoni |
| author_sort | Massimo Mapelli |
| collection | DOAJ |
| description | Background
The COVID-19 pandemic has led to significant concern due to its impact on human health, particularly through pneumonia-induced lung damage. Surfactant proteins A and D (SP-A and SP-D) are implicated in COVID-19 lung damage, but the role of surfactant protein B (SP-B) remains unclear.
Methods
We conducted a single-centre, prospective observational study involving 73 hospitalised COVID-19 pneumonia patients. SP-B levels were measured within 48 h of admission, alongside SP-A and SP-D in a subset. Clinical data were collected, and follow-up visits were conducted after 6 months.
Results
At hospitalisation, circulating immature SP-B levels measured in 73 patients (median 26.31 arbitrary units (AU) (interquartile range 14.27–41.31)) correlated significantly with lung involvement (r=0.447, p<0.001) and oxygen support requirement (p=0.005). SP-B levels did not predict mechanical ventilation or intensive care unit admission. SP-B decreased significantly (p<0.001) from 25.53 AU (14.36–41.46) at the acute hospitalisation to 12.73 AU (9.12–20.23) at the 6-month follow-up, whereas SP-A and SP-D did not change significantly. Immature SP-B (but not SP-A and SP-D) was confirmed to be significantly associated with the need for oxygen support (n=26, 58%) during the hospitalisation (p<0.05).
Conclusion
Immature SP-B emerges as a potential biomarker for COVID-19 pneumonia severity and prognosis. Its dynamic changes suggest utility in monitoring disease progression and long-term outcomes, despite limitations in predicting hard end-points. Larger studies are needed to validate these findings and understand the underlying mechanisms of surfactant protein dysregulation in COVID-19 pathogenesis. |
| format | Article |
| id | doaj-art-10a13e93f0d0472886e07d6084d50dbb |
| institution | Kabale University |
| issn | 2312-0541 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj-art-10a13e93f0d0472886e07d6084d50dbb2025-01-14T09:50:21ZengEuropean Respiratory SocietyERJ Open Research2312-05412024-11-0110610.1183/23120541.00301-202400301-2024Surfactant-derived protein type B: a new biomarker linked to respiratory failure and lung damage in mild to moderate SARS-CoV-2 pneumoniaMassimo Mapelli0Elisabetta Salvioni1Irene Mattavelli2Cristina Banfi3Stefania Ghilardi4Arianna Greco5Maria Luisa Biondi6Sara Rovai7Elisabetta Mancini8Sergio Harari9Piergiuseppe Agostoni10 Centro Cardiologico Monzino, IRCCS, Milan, Italy Centro Cardiologico Monzino, IRCCS, Milan, Italy Centro Cardiologico Monzino, IRCCS, Milan, Italy Centro Cardiologico Monzino, IRCCS, Milan, Italy Centro Cardiologico Monzino, IRCCS, Milan, Italy Centro Cardiologico Monzino, IRCCS, Milan, Italy Centro Cardiologico Monzino, IRCCS, Milan, Italy Centro Cardiologico Monzino, IRCCS, Milan, Italy Centro Cardiologico Monzino, IRCCS, Milan, Italy Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy Centro Cardiologico Monzino, IRCCS, Milan, Italy Background The COVID-19 pandemic has led to significant concern due to its impact on human health, particularly through pneumonia-induced lung damage. Surfactant proteins A and D (SP-A and SP-D) are implicated in COVID-19 lung damage, but the role of surfactant protein B (SP-B) remains unclear. Methods We conducted a single-centre, prospective observational study involving 73 hospitalised COVID-19 pneumonia patients. SP-B levels were measured within 48 h of admission, alongside SP-A and SP-D in a subset. Clinical data were collected, and follow-up visits were conducted after 6 months. Results At hospitalisation, circulating immature SP-B levels measured in 73 patients (median 26.31 arbitrary units (AU) (interquartile range 14.27–41.31)) correlated significantly with lung involvement (r=0.447, p<0.001) and oxygen support requirement (p=0.005). SP-B levels did not predict mechanical ventilation or intensive care unit admission. SP-B decreased significantly (p<0.001) from 25.53 AU (14.36–41.46) at the acute hospitalisation to 12.73 AU (9.12–20.23) at the 6-month follow-up, whereas SP-A and SP-D did not change significantly. Immature SP-B (but not SP-A and SP-D) was confirmed to be significantly associated with the need for oxygen support (n=26, 58%) during the hospitalisation (p<0.05). Conclusion Immature SP-B emerges as a potential biomarker for COVID-19 pneumonia severity and prognosis. Its dynamic changes suggest utility in monitoring disease progression and long-term outcomes, despite limitations in predicting hard end-points. Larger studies are needed to validate these findings and understand the underlying mechanisms of surfactant protein dysregulation in COVID-19 pathogenesis.http://openres.ersjournals.com/content/10/6/00301-2024.full |
| spellingShingle | Massimo Mapelli Elisabetta Salvioni Irene Mattavelli Cristina Banfi Stefania Ghilardi Arianna Greco Maria Luisa Biondi Sara Rovai Elisabetta Mancini Sergio Harari Piergiuseppe Agostoni Surfactant-derived protein type B: a new biomarker linked to respiratory failure and lung damage in mild to moderate SARS-CoV-2 pneumonia ERJ Open Research |
| title | Surfactant-derived protein type B: a new biomarker linked to respiratory failure and lung damage in mild to moderate SARS-CoV-2 pneumonia |
| title_full | Surfactant-derived protein type B: a new biomarker linked to respiratory failure and lung damage in mild to moderate SARS-CoV-2 pneumonia |
| title_fullStr | Surfactant-derived protein type B: a new biomarker linked to respiratory failure and lung damage in mild to moderate SARS-CoV-2 pneumonia |
| title_full_unstemmed | Surfactant-derived protein type B: a new biomarker linked to respiratory failure and lung damage in mild to moderate SARS-CoV-2 pneumonia |
| title_short | Surfactant-derived protein type B: a new biomarker linked to respiratory failure and lung damage in mild to moderate SARS-CoV-2 pneumonia |
| title_sort | surfactant derived protein type b a new biomarker linked to respiratory failure and lung damage in mild to moderate sars cov 2 pneumonia |
| url | http://openres.ersjournals.com/content/10/6/00301-2024.full |
| work_keys_str_mv | AT massimomapelli surfactantderivedproteintypebanewbiomarkerlinkedtorespiratoryfailureandlungdamageinmildtomoderatesarscov2pneumonia AT elisabettasalvioni surfactantderivedproteintypebanewbiomarkerlinkedtorespiratoryfailureandlungdamageinmildtomoderatesarscov2pneumonia AT irenemattavelli surfactantderivedproteintypebanewbiomarkerlinkedtorespiratoryfailureandlungdamageinmildtomoderatesarscov2pneumonia AT cristinabanfi surfactantderivedproteintypebanewbiomarkerlinkedtorespiratoryfailureandlungdamageinmildtomoderatesarscov2pneumonia AT stefaniaghilardi surfactantderivedproteintypebanewbiomarkerlinkedtorespiratoryfailureandlungdamageinmildtomoderatesarscov2pneumonia AT ariannagreco surfactantderivedproteintypebanewbiomarkerlinkedtorespiratoryfailureandlungdamageinmildtomoderatesarscov2pneumonia AT marialuisabiondi surfactantderivedproteintypebanewbiomarkerlinkedtorespiratoryfailureandlungdamageinmildtomoderatesarscov2pneumonia AT sararovai surfactantderivedproteintypebanewbiomarkerlinkedtorespiratoryfailureandlungdamageinmildtomoderatesarscov2pneumonia AT elisabettamancini surfactantderivedproteintypebanewbiomarkerlinkedtorespiratoryfailureandlungdamageinmildtomoderatesarscov2pneumonia AT sergioharari surfactantderivedproteintypebanewbiomarkerlinkedtorespiratoryfailureandlungdamageinmildtomoderatesarscov2pneumonia AT piergiuseppeagostoni surfactantderivedproteintypebanewbiomarkerlinkedtorespiratoryfailureandlungdamageinmildtomoderatesarscov2pneumonia |