Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis

Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis

Abstract The limited availability of therapeutic options for patients with triple-negative breast cancer (TNBC) contributes to the high rate of metastatic recurrence and poor prognosis. Ferroptosis is a type of cell death caused by iron-dependent lipid peroxidation and counteracted by the antioxidan...

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Main Authors: Tobias Ackermann, Engy Shokry, Ruhi Deshmukh, Jayanthi Anand, Laura C A Galbraith, Louise Mitchell, Giovanny Rodriguez-Blanco, Victor H Villar, Britt Amber Sterken, Colin Nixon, Sara Zanivan, Karen Blyth, David Sumpton, Saverio Tardito
Format: Article
Language:English
Published: Springer Nature 2024-10-01
Series:EMBO Molecular Medicine
Subjects:
Breast Cancer
Ferroptosis
Lipid Metabolism
Metastasis
Selenium Metabolism
Online Access:https://doi.org/10.1038/s44321-024-00142-x
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https://doi.org/10.1038/s44321-024-00142-x

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