Effects of Empagliflozin and Dapagliflozin in alleviating cardiac fibrosis through SIRT6-mediated oxidative stress reduction

Effects of Empagliflozin and Dapagliflozin in alleviating cardiac fibrosis through SIRT6-mediated oxidative stress reduction

Abstract Sodium-glucose co-transport protein 2 (SGLT2) inhibitors, a novel category of oral hypoglycemic agents, offer a promising outlook for individuals experiencing heart failure with reduced ejection fraction. Evidence is emerging that highlights their potential in alleviating myocardial fibrosi...

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Bibliographic Details
Main Authors: Hong-xia Ma, Ke Wu, Fei-hong Dong, Bing-kun Cai, Di Wu, Hui-yi Lu
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Myocardial fibrosis
Empagliflozin
Dapagliflozin
Oxidative stress injury
SIRT6
Online Access:https://doi.org/10.1038/s41598-024-80829-w
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