Hospital use in survivors of transient ischaemic attack compared with survivors of stroke in central China: a nested case–control study

Objectives There is a lack of knowledge regarding post-discharge hospitalisation utilisation after transient ischaemic attack (TIA) in China. The aim of this study is to quantify rehospitalisation use in survivors of TIA compared with their own previous hospital use and matched survivors of stroke.D...

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Main Authors: Sangsang Li, Qingfeng Tian, Junxing Fan, Zhan Shi, Bingxin Guo, Huanan Chen, Yapeng Li, Songhe Shi
Format: Article
Language:English
Published: BMJ Publishing Group 2019-07-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/9/7/e024052.full
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author Sangsang Li
Qingfeng Tian
Junxing Fan
Zhan Shi
Bingxin Guo
Huanan Chen
Yapeng Li
Songhe Shi
author_facet Sangsang Li
Qingfeng Tian
Junxing Fan
Zhan Shi
Bingxin Guo
Huanan Chen
Yapeng Li
Songhe Shi
author_sort Sangsang Li
collection DOAJ
description Objectives There is a lack of knowledge regarding post-discharge hospitalisation utilisation after transient ischaemic attack (TIA) in China. The aim of this study is to quantify rehospitalisation use in survivors of TIA compared with their own previous hospital use and matched survivors of stroke.Design Nested case–control study of electronic medical records datasets.Setting 958 hospitals in Henan, China, from July 2012 to December 2015.Participants In total, 4823 survivors of stroke were matched to the TIA cohort (average age: 64.5 years; proportion of men: 48.4%) at a 1:1 ratio. All subjects with an onset of stroke/TIA were recorded with a 1-year look-back and follow-up.Outcome measures Adjusted difference-in-differences (DID) values in 1-year hospital lengths of stay (LOSs) and readmission within 7, 30 and 90 days.Results There was an increase in hospital admissions in survivors of TIA in the year after the index hospitalisation compared with the prior year. Of the 2449 rehospitalisation events that occurred during the first year after TIA, stroke (20.6%) was the most common reason for rehospitalisation. There was no difference in the stroke-specific readmission rates between the TIA and stroke cohorts (p=0.198). The TIA cohort had fewer readmissions within 30 days and 90 days after all-cause discharge compared with the controls. The corresponding covariate-adjusted DID values were −3.5 percentage points (95% CI −5.3 to −1.8) and −4.5 (95% CI −6.5 to −2.4), respectively. A similar trend was observed in the 1-year LOS. In the stratified analysis, the DID reductions were not significant in patients with more comorbidities or in rural patients.Conclusions Compared with survivors of stroke, survivors of TIA use fewer hospital resources up to 1 year post-discharge. Greater attention to TIAs among patients with more comorbidities and rural patients may provide an opportunity to reduce hospital use.
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spelling doaj-art-1082c1f22cc44f09b99177ca974be4fa2024-11-23T18:40:09ZengBMJ Publishing GroupBMJ Open2044-60552019-07-019710.1136/bmjopen-2018-024052Hospital use in survivors of transient ischaemic attack compared with survivors of stroke in central China: a nested case–control studySangsang Li0Qingfeng Tian1Junxing Fan2Zhan Shi3Bingxin Guo4Huanan Chen5Yapeng Li6Songhe Shi7Department of Epidemiology and Biostatistics, Zhengzhou University, Zhengzhou, ChinaDepartment of Social Medicine, Zhengzhou University, Zhengzhou, ChinaStatistical Information Center, Health and Family Planning Commission of Henan Province, Zhengzhou, ChinaDepartment of Pharmacy, Zhengzhou People’s Hospital, Zhengzhou, UKDepartment of Epidemiology and Biostatistics, Zhengzhou University, Zhengzhou, ChinaDepartment of Epidemiology and Biostatistics, Zhengzhou University, Zhengzhou, China6 Neurology, Zhengzhou University First Affiliated Hospital, Zhengzhou, Henan, ChinaDepartment of Epidemiology and Biostatistics, Zhengzhou University, Zhengzhou, ChinaObjectives There is a lack of knowledge regarding post-discharge hospitalisation utilisation after transient ischaemic attack (TIA) in China. The aim of this study is to quantify rehospitalisation use in survivors of TIA compared with their own previous hospital use and matched survivors of stroke.Design Nested case–control study of electronic medical records datasets.Setting 958 hospitals in Henan, China, from July 2012 to December 2015.Participants In total, 4823 survivors of stroke were matched to the TIA cohort (average age: 64.5 years; proportion of men: 48.4%) at a 1:1 ratio. All subjects with an onset of stroke/TIA were recorded with a 1-year look-back and follow-up.Outcome measures Adjusted difference-in-differences (DID) values in 1-year hospital lengths of stay (LOSs) and readmission within 7, 30 and 90 days.Results There was an increase in hospital admissions in survivors of TIA in the year after the index hospitalisation compared with the prior year. Of the 2449 rehospitalisation events that occurred during the first year after TIA, stroke (20.6%) was the most common reason for rehospitalisation. There was no difference in the stroke-specific readmission rates between the TIA and stroke cohorts (p=0.198). The TIA cohort had fewer readmissions within 30 days and 90 days after all-cause discharge compared with the controls. The corresponding covariate-adjusted DID values were −3.5 percentage points (95% CI −5.3 to −1.8) and −4.5 (95% CI −6.5 to −2.4), respectively. A similar trend was observed in the 1-year LOS. In the stratified analysis, the DID reductions were not significant in patients with more comorbidities or in rural patients.Conclusions Compared with survivors of stroke, survivors of TIA use fewer hospital resources up to 1 year post-discharge. Greater attention to TIAs among patients with more comorbidities and rural patients may provide an opportunity to reduce hospital use.https://bmjopen.bmj.com/content/9/7/e024052.full
spellingShingle Sangsang Li
Qingfeng Tian
Junxing Fan
Zhan Shi
Bingxin Guo
Huanan Chen
Yapeng Li
Songhe Shi
Hospital use in survivors of transient ischaemic attack compared with survivors of stroke in central China: a nested case–control study
BMJ Open
title Hospital use in survivors of transient ischaemic attack compared with survivors of stroke in central China: a nested case–control study
title_full Hospital use in survivors of transient ischaemic attack compared with survivors of stroke in central China: a nested case–control study
title_fullStr Hospital use in survivors of transient ischaemic attack compared with survivors of stroke in central China: a nested case–control study
title_full_unstemmed Hospital use in survivors of transient ischaemic attack compared with survivors of stroke in central China: a nested case–control study
title_short Hospital use in survivors of transient ischaemic attack compared with survivors of stroke in central China: a nested case–control study
title_sort hospital use in survivors of transient ischaemic attack compared with survivors of stroke in central china a nested case control study
url https://bmjopen.bmj.com/content/9/7/e024052.full
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