Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1
Summary 1. Kindlin-3 but not talin-1 contributes to integrin inside-out signaling induced β2 integrin clustering. 2. The Pleckstrin homology domain of kindlin-3 was critical for its mediated β2 integrin clustering.
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Main Authors: | Yuanyuan Wu, Ziming Cao, Wei Liu, Jason G. Cahoon, Kepeng Wang, Penghua Wang, Liang Hu, Yunfeng Chen, Markus Moser, Anthony T. Vella, Klaus Ley, Lai Wen, Zhichao Fan |
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Format: | Article |
Language: | English |
Published: |
BMC
2025-01-01
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Series: | Cell Communication and Signaling |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12964-024-02024-8 |
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