Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1
Summary 1. Kindlin-3 but not talin-1 contributes to integrin inside-out signaling induced β2 integrin clustering. 2. The Pleckstrin homology domain of kindlin-3 was critical for its mediated β2 integrin clustering.
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-024-02024-8 |
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| _version_ | 1841544411360526336 |
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| author | Yuanyuan Wu Ziming Cao Wei Liu Jason G. Cahoon Kepeng Wang Penghua Wang Liang Hu Yunfeng Chen Markus Moser Anthony T. Vella Klaus Ley Lai Wen Zhichao Fan |
| author_facet | Yuanyuan Wu Ziming Cao Wei Liu Jason G. Cahoon Kepeng Wang Penghua Wang Liang Hu Yunfeng Chen Markus Moser Anthony T. Vella Klaus Ley Lai Wen Zhichao Fan |
| author_sort | Yuanyuan Wu |
| collection | DOAJ |
| description | Summary 1. Kindlin-3 but not talin-1 contributes to integrin inside-out signaling induced β2 integrin clustering. 2. The Pleckstrin homology domain of kindlin-3 was critical for its mediated β2 integrin clustering. |
| format | Article |
| id | doaj-art-104547b912734f7d8ebac307fb889653 |
| institution | Kabale University |
| issn | 1478-811X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj-art-104547b912734f7d8ebac307fb8896532025-01-12T12:33:04ZengBMCCell Communication and Signaling1478-811X2025-01-0123111110.1186/s12964-024-02024-8Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1Yuanyuan Wu0Ziming Cao1Wei Liu2Jason G. Cahoon3Kepeng Wang4Penghua Wang5Liang Hu6Yunfeng Chen7Markus Moser8Anthony T. Vella9Klaus Ley10Lai Wen11Zhichao Fan12Department of Immunology, University of Connecticut School of MedicineDepartment of Immunology, University of Connecticut School of MedicineDepartment of Immunology, University of Connecticut School of MedicineDepartment of Immunology, University of Connecticut School of MedicineDepartment of Immunology, University of Connecticut School of MedicineDepartment of Immunology, University of Connecticut School of MedicineAcademy of Integrative Medicine, Shanghai University of Traditional Chinese MedicineDepartment of Biochemistry and Molecular Biology, Department of Pathology, University of Texas Medical BranchInstitute of Experimental Hematology, School of Medicine, Technical University of MunichDepartment of Immunology, University of Connecticut School of MedicineImmunology Center of Georgia, Augusta UniversityDepartment of Pharmacology, University of Nevada School of MedicineDepartment of Immunology, University of Connecticut School of MedicineSummary 1. Kindlin-3 but not talin-1 contributes to integrin inside-out signaling induced β2 integrin clustering. 2. The Pleckstrin homology domain of kindlin-3 was critical for its mediated β2 integrin clustering.https://doi.org/10.1186/s12964-024-02024-8Neutrophil adhesionβ2 integrinIntegrin clusteringKindlin-3Talin-1STORM |
| spellingShingle | Yuanyuan Wu Ziming Cao Wei Liu Jason G. Cahoon Kepeng Wang Penghua Wang Liang Hu Yunfeng Chen Markus Moser Anthony T. Vella Klaus Ley Lai Wen Zhichao Fan Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1 Cell Communication and Signaling Neutrophil adhesion β2 integrin Integrin clustering Kindlin-3 Talin-1 STORM |
| title | Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1 |
| title_full | Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1 |
| title_fullStr | Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1 |
| title_full_unstemmed | Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1 |
| title_short | Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1 |
| title_sort | nanoscopy reveals integrin clustering reliant on kindlin 3 but not talin 1 |
| topic | Neutrophil adhesion β2 integrin Integrin clustering Kindlin-3 Talin-1 STORM |
| url | https://doi.org/10.1186/s12964-024-02024-8 |
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