The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United States
Abstract Erectile dysfunction(ED), a prevalent condition within the male genitourinary system, significantly impairs the quality of life for affected men. Although certain inflammatory indicators, such as the neutrophil-to-lymphocyte ratio(NLR), systemic inflammatory response index (SIRI), and syste...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-12-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-83733-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559530204299264 |
|---|---|
| author | Yi Zhang Tingzhen Li Qixin Chen Maobiao Shen Xinyang Fu Changjin Liu |
| author_facet | Yi Zhang Tingzhen Li Qixin Chen Maobiao Shen Xinyang Fu Changjin Liu |
| author_sort | Yi Zhang |
| collection | DOAJ |
| description | Abstract Erectile dysfunction(ED), a prevalent condition within the male genitourinary system, significantly impairs the quality of life for affected men. Although certain inflammatory indicators, such as the neutrophil-to-lymphocyte ratio(NLR), systemic inflammatory response index (SIRI), and systemic immune-inflammation index(SII), have been linked to ED, the correlation with other markers and their impact on survival outcomes in ED patients remain largely unexplored. This research aims to investigate the correlation between inflammatory biomarkers derived from a complete blood cell count(CBC) and the occurrence of ED. Data regarding ED were extracted from the 2001–2004 National Health and Nutrition Examination Survey(NHANES), and mortality events were ascertained through the National Death Index up to December 2019. The CBC-derived inflammatory indicators assessed in this study included the NLR, derived neutrophil-to-lymphocyte ratio(dNLR), monocyte-to-lymphocyte ratio(MLR), neutrophil-monocyte to lymphocyte ratio (NMLR), SIRI, and SII. The prognostic significance of these CBC-derived inflammatory indicators was evaluated using random survival forests(RSF) analysis. Our study encompassed a cohort of 3,639 individuals, among whom 1,031 were diagnosed with ED. Among individuals with ED, 610 experienced all-cause mortality. Following adjustment for all confounding variables, it was observed that elevated levels of NLR(OR = 1.09, 95%CI 1.00–1.19, p = 0.021), MLR (OR = 2.97, 95% CI 1.18–7.50, p = 0.01), NMLR(OR = 1.10, 95% CI 1.01–1.11, p = 0.006), and SIRI(OR = 1.11, 95% CI 1.01–1.22, p = 0.017) were associated with an increased prevalence of ED. Among participants with ED, those in the highest quartile of NLR(HR = 1.06, 95% CI 1.00–1.11, p = 0.032), MLR(HR = 2.00, 95% CI 1.33–3.01, p < 0.001), NMLR (HR = 1.06, 95% CI 1.01–1.11, p = 0.024), and SII(HR = 1.00, 95% CI 1.00–1.00, p = 0.015) exhibited an elevated risk of all-cause mortality compared to those in the lower levels of inflammation-derived indicators. Our research suggests that, compared with other inflammatory markers derived from complete blood cell count, MLR has the highest predictive power for the prevalence of ED and all-cause mortality in these populations. |
| format | Article |
| id | doaj-art-1043057e4be144d9986de166d7af63a2 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-1043057e4be144d9986de166d7af63a22025-01-05T12:24:08ZengNature PortfolioScientific Reports2045-23222024-12-0114111210.1038/s41598-024-83733-5The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United StatesYi Zhang0Tingzhen Li1Qixin Chen2Maobiao Shen3Xinyang Fu4Changjin Liu5Department of Urology, Kaiping Central HospitalDepartment of Nail and Breast Surgery, Kaiping Central HospitalDepartment of Neurosurgery, Kaiping Central HospitalChinese Orthopedics and Traumatology, Kaiping Central HospitalDepartment of Urology, Kaiping Central HospitalDepartment of Urology, Kaiping Central HospitalAbstract Erectile dysfunction(ED), a prevalent condition within the male genitourinary system, significantly impairs the quality of life for affected men. Although certain inflammatory indicators, such as the neutrophil-to-lymphocyte ratio(NLR), systemic inflammatory response index (SIRI), and systemic immune-inflammation index(SII), have been linked to ED, the correlation with other markers and their impact on survival outcomes in ED patients remain largely unexplored. This research aims to investigate the correlation between inflammatory biomarkers derived from a complete blood cell count(CBC) and the occurrence of ED. Data regarding ED were extracted from the 2001–2004 National Health and Nutrition Examination Survey(NHANES), and mortality events were ascertained through the National Death Index up to December 2019. The CBC-derived inflammatory indicators assessed in this study included the NLR, derived neutrophil-to-lymphocyte ratio(dNLR), monocyte-to-lymphocyte ratio(MLR), neutrophil-monocyte to lymphocyte ratio (NMLR), SIRI, and SII. The prognostic significance of these CBC-derived inflammatory indicators was evaluated using random survival forests(RSF) analysis. Our study encompassed a cohort of 3,639 individuals, among whom 1,031 were diagnosed with ED. Among individuals with ED, 610 experienced all-cause mortality. Following adjustment for all confounding variables, it was observed that elevated levels of NLR(OR = 1.09, 95%CI 1.00–1.19, p = 0.021), MLR (OR = 2.97, 95% CI 1.18–7.50, p = 0.01), NMLR(OR = 1.10, 95% CI 1.01–1.11, p = 0.006), and SIRI(OR = 1.11, 95% CI 1.01–1.22, p = 0.017) were associated with an increased prevalence of ED. Among participants with ED, those in the highest quartile of NLR(HR = 1.06, 95% CI 1.00–1.11, p = 0.032), MLR(HR = 2.00, 95% CI 1.33–3.01, p < 0.001), NMLR (HR = 1.06, 95% CI 1.01–1.11, p = 0.024), and SII(HR = 1.00, 95% CI 1.00–1.00, p = 0.015) exhibited an elevated risk of all-cause mortality compared to those in the lower levels of inflammation-derived indicators. Our research suggests that, compared with other inflammatory markers derived from complete blood cell count, MLR has the highest predictive power for the prevalence of ED and all-cause mortality in these populations.https://doi.org/10.1038/s41598-024-83733-5Inflammatory markersComplete blood cellErectile dysfunctionNHANESCross-sectional study |
| spellingShingle | Yi Zhang Tingzhen Li Qixin Chen Maobiao Shen Xinyang Fu Changjin Liu The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United States Scientific Reports Inflammatory markers Complete blood cell Erectile dysfunction NHANES Cross-sectional study |
| title | The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United States |
| title_full | The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United States |
| title_fullStr | The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United States |
| title_full_unstemmed | The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United States |
| title_short | The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United States |
| title_sort | relationship between complete blood cell count derived inflammatory biomarkers and erectile dysfunction in the united states |
| topic | Inflammatory markers Complete blood cell Erectile dysfunction NHANES Cross-sectional study |
| url | https://doi.org/10.1038/s41598-024-83733-5 |
| work_keys_str_mv | AT yizhang therelationshipbetweencompletebloodcellcountderivedinflammatorybiomarkersanderectiledysfunctionintheunitedstates AT tingzhenli therelationshipbetweencompletebloodcellcountderivedinflammatorybiomarkersanderectiledysfunctionintheunitedstates AT qixinchen therelationshipbetweencompletebloodcellcountderivedinflammatorybiomarkersanderectiledysfunctionintheunitedstates AT maobiaoshen therelationshipbetweencompletebloodcellcountderivedinflammatorybiomarkersanderectiledysfunctionintheunitedstates AT xinyangfu therelationshipbetweencompletebloodcellcountderivedinflammatorybiomarkersanderectiledysfunctionintheunitedstates AT changjinliu therelationshipbetweencompletebloodcellcountderivedinflammatorybiomarkersanderectiledysfunctionintheunitedstates AT yizhang relationshipbetweencompletebloodcellcountderivedinflammatorybiomarkersanderectiledysfunctionintheunitedstates AT tingzhenli relationshipbetweencompletebloodcellcountderivedinflammatorybiomarkersanderectiledysfunctionintheunitedstates AT qixinchen relationshipbetweencompletebloodcellcountderivedinflammatorybiomarkersanderectiledysfunctionintheunitedstates AT maobiaoshen relationshipbetweencompletebloodcellcountderivedinflammatorybiomarkersanderectiledysfunctionintheunitedstates AT xinyangfu relationshipbetweencompletebloodcellcountderivedinflammatorybiomarkersanderectiledysfunctionintheunitedstates AT changjinliu relationshipbetweencompletebloodcellcountderivedinflammatorybiomarkersanderectiledysfunctionintheunitedstates |