IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury
Introduction: Patients with severe fibrosis or cirrhosis are at high risk for liver-related complications, even after successful antiviral treatment and/or regression of fibrosis. These are the first published results concerning the role of IL-28B genotypes as predictors of the durability of sustai...
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The Journal of Infection in Developing Countries
2019-05-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/11351 |
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| author | Jelena Jordovic Jasmina Simonovic-Babic Vladimir Gasic Nikola Kotur Branka Zukic Sonja Pavlovic Ivana Lazarevic Danijela Karalic Natasa Katanic Natasa Nikolic Aleksandar Urosevic Jelena Nestorov Dragan Delic Ksenija Bojovic |
| author_facet | Jelena Jordovic Jasmina Simonovic-Babic Vladimir Gasic Nikola Kotur Branka Zukic Sonja Pavlovic Ivana Lazarevic Danijela Karalic Natasa Katanic Natasa Nikolic Aleksandar Urosevic Jelena Nestorov Dragan Delic Ksenija Bojovic |
| author_sort | Jelena Jordovic |
| collection | DOAJ |
| description |
Introduction: Patients with severe fibrosis or cirrhosis are at high risk for liver-related complications, even after successful antiviral treatment and/or regression of fibrosis. These are the first published results concerning the role of IL-28B genotypes as predictors of the durability of sustained virological response (SVR) and long-term outcome, in patients with baseline severe fibrosis and cirrhosis caused by hepatitis C (HCV) infection.
Methodology: Genetic testing for three different single nucleotide polymorphisms (SNP) near the IL28B gene, rs12979860, rs12980275 and rs8099917, was performed in 42 patients with HCV-related advanced fibrosis and cirrhosis, who achieved SVR after successful interferon-based treatment. Baseline clinical and laboratory parameters were analysed, as well as IL28B genotype association with late virological relapse, fibrosis progression and clinical outcomes.
Results: The most prevalent genotypes in all three tested SNP positions were: CCrs12979860 genotype in 69% of patients, GTrs8099917 in 78.6% and GGrs12980275 in 47.6% of patients. The presence of IL28B CCrs12979860 genotype was identified as a negative predictor of late virological relapse. Further analysis did not confirm the association of other IL28B genotypes with the progression of fibrosis and clinical outcomes.
Conclusions: Varying long-term prognosis in patients with HCV-related severe fibrosis and cirrhosis is due to multiple interactions between host genetic factors, virus and environment. These are first published results demonstrating the significance of IL28B CCrs12979860 genotype as a negative predictor of late virological relapse. A further investigation concerning genetic factors is necessary to identify patients under risk for late relapse, complications and unfavorable outcomes, so that they can be reevaluated and offered new treatment options.
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| format | Article |
| id | doaj-art-103f2eb8c1bb43bb817f04e4795c48bc |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2019-05-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-103f2eb8c1bb43bb817f04e4795c48bc2025-08-20T03:52:42ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802019-05-01130610.3855/jidc.11351IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injuryJelena Jordovic0Jasmina Simonovic-Babic1Vladimir Gasic2Nikola Kotur3Branka Zukic4Sonja Pavlovic5Ivana Lazarevic6Danijela Karalic7Natasa Katanic8Natasa Nikolic9Aleksandar Urosevic10Jelena Nestorov11Dragan Delic12Ksenija Bojovic13Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, SerbiaClinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, SerbiaLaboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, SerbiaLaboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, BelgradeLaboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, BelgradeMedical Faculty, University of Belgrade, Belgrade, SerbiaInstitute of Microbiology and Immunology, Belgrade, SerbiaInstitute of Microbiology and Immunology, Belgrade, SerbiaClinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, SerbiaClinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, SerbiaClinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, SerbiaMedical Faculty, University of Belgrade, Belgrade, SerbiaClinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, SerbiaClinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia Introduction: Patients with severe fibrosis or cirrhosis are at high risk for liver-related complications, even after successful antiviral treatment and/or regression of fibrosis. These are the first published results concerning the role of IL-28B genotypes as predictors of the durability of sustained virological response (SVR) and long-term outcome, in patients with baseline severe fibrosis and cirrhosis caused by hepatitis C (HCV) infection. Methodology: Genetic testing for three different single nucleotide polymorphisms (SNP) near the IL28B gene, rs12979860, rs12980275 and rs8099917, was performed in 42 patients with HCV-related advanced fibrosis and cirrhosis, who achieved SVR after successful interferon-based treatment. Baseline clinical and laboratory parameters were analysed, as well as IL28B genotype association with late virological relapse, fibrosis progression and clinical outcomes. Results: The most prevalent genotypes in all three tested SNP positions were: CCrs12979860 genotype in 69% of patients, GTrs8099917 in 78.6% and GGrs12980275 in 47.6% of patients. The presence of IL28B CCrs12979860 genotype was identified as a negative predictor of late virological relapse. Further analysis did not confirm the association of other IL28B genotypes with the progression of fibrosis and clinical outcomes. Conclusions: Varying long-term prognosis in patients with HCV-related severe fibrosis and cirrhosis is due to multiple interactions between host genetic factors, virus and environment. These are first published results demonstrating the significance of IL28B CCrs12979860 genotype as a negative predictor of late virological relapse. A further investigation concerning genetic factors is necessary to identify patients under risk for late relapse, complications and unfavorable outcomes, so that they can be reevaluated and offered new treatment options. https://jidc.org/index.php/journal/article/view/11351interleukine 28Blate relapseoutcome |
| spellingShingle | Jelena Jordovic Jasmina Simonovic-Babic Vladimir Gasic Nikola Kotur Branka Zukic Sonja Pavlovic Ivana Lazarevic Danijela Karalic Natasa Katanic Natasa Nikolic Aleksandar Urosevic Jelena Nestorov Dragan Delic Ksenija Bojovic IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury Journal of Infection in Developing Countries interleukine 28B late relapse outcome |
| title | IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury |
| title_full | IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury |
| title_fullStr | IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury |
| title_full_unstemmed | IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury |
| title_short | IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury |
| title_sort | il 28b genotypes as predictors of long term outcome in patients with hepatitis c related severe liver injury |
| topic | interleukine 28B late relapse outcome |
| url | https://jidc.org/index.php/journal/article/view/11351 |
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