Correlation analysis of the triglyceride–glucose index and related parameters in metabolic dysfunction-associated fatty liver disease
Abstract This study aimed to investigate the correlation and predictive value of TyG and related parameters with metabolic dysfunction-associated fatty liver disease (MAFLD) MAFLD. This study retrospectively included individuals who underwent health examinations and abdominal ultrasound from July 20...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84809-y |
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| author | Xin Yang Huiting Rao Yi Yuan Nan Hu Xinmei Zhang Yingxin Zeng Guodong Xia |
| author_facet | Xin Yang Huiting Rao Yi Yuan Nan Hu Xinmei Zhang Yingxin Zeng Guodong Xia |
| author_sort | Xin Yang |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the correlation and predictive value of TyG and related parameters with metabolic dysfunction-associated fatty liver disease (MAFLD) MAFLD. This study retrospectively included individuals who underwent health examinations and abdominal ultrasound from July 2021 to June 2024 at the Affiliated Hospital of Southwest Medical University, Sichuan Province, China. A total of 71,299 subjects’ clinical and laboratory data were extracted, the correlation between TyG and related parameters and MAFLD was analyzed via univariate and multivariate logistic regression methods, and the nonlinear relationship between the TyG index and the risk of MAFLD was explored via restricted cubic spline (RCS) analysis. The predictive value of TyG and related parameters for MAFLD was assessed using the receiver operating characteristic (ROC) curves and the area under the ROC curve (AUC). TyG and related parameters were positively correlated with MAFLD, and the results remained unchanged after adjustment for the corresponding parameters. RCS analysis revealed a significant dose‒response relationship between TyG and related parameters and MAFLD. ROC curve analysis revealed AUC values of 0.83 (0.82–0.83), 0.92 (0.91–0.92), 0.90 (0.90–0.91), and 0.87 (0.87–0.88) for TyG, TyG-BMI, TyG-WC, and TyG-WHR, respectively. Subgroup analyses revealed that the TyG index and related parameters had greater predictive value in the female, younger, and BMI < 23.7 populations. |
| format | Article |
| id | doaj-art-102f91788e834b098305b0220d93fb6b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-102f91788e834b098305b0220d93fb6b2025-01-05T12:15:13ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-024-84809-yCorrelation analysis of the triglyceride–glucose index and related parameters in metabolic dysfunction-associated fatty liver diseaseXin Yang0Huiting Rao1Yi Yuan2Nan Hu3Xinmei Zhang4Yingxin Zeng5Guodong Xia6Department of Gastroenterology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Presbyatrics, Luzhou People’s HospitalDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical UniversityAbstract This study aimed to investigate the correlation and predictive value of TyG and related parameters with metabolic dysfunction-associated fatty liver disease (MAFLD) MAFLD. This study retrospectively included individuals who underwent health examinations and abdominal ultrasound from July 2021 to June 2024 at the Affiliated Hospital of Southwest Medical University, Sichuan Province, China. A total of 71,299 subjects’ clinical and laboratory data were extracted, the correlation between TyG and related parameters and MAFLD was analyzed via univariate and multivariate logistic regression methods, and the nonlinear relationship between the TyG index and the risk of MAFLD was explored via restricted cubic spline (RCS) analysis. The predictive value of TyG and related parameters for MAFLD was assessed using the receiver operating characteristic (ROC) curves and the area under the ROC curve (AUC). TyG and related parameters were positively correlated with MAFLD, and the results remained unchanged after adjustment for the corresponding parameters. RCS analysis revealed a significant dose‒response relationship between TyG and related parameters and MAFLD. ROC curve analysis revealed AUC values of 0.83 (0.82–0.83), 0.92 (0.91–0.92), 0.90 (0.90–0.91), and 0.87 (0.87–0.88) for TyG, TyG-BMI, TyG-WC, and TyG-WHR, respectively. Subgroup analyses revealed that the TyG index and related parameters had greater predictive value in the female, younger, and BMI < 23.7 populations.https://doi.org/10.1038/s41598-024-84809-yTyG and related parametersMAFLDCorrelation analysis |
| spellingShingle | Xin Yang Huiting Rao Yi Yuan Nan Hu Xinmei Zhang Yingxin Zeng Guodong Xia Correlation analysis of the triglyceride–glucose index and related parameters in metabolic dysfunction-associated fatty liver disease Scientific Reports TyG and related parameters MAFLD Correlation analysis |
| title | Correlation analysis of the triglyceride–glucose index and related parameters in metabolic dysfunction-associated fatty liver disease |
| title_full | Correlation analysis of the triglyceride–glucose index and related parameters in metabolic dysfunction-associated fatty liver disease |
| title_fullStr | Correlation analysis of the triglyceride–glucose index and related parameters in metabolic dysfunction-associated fatty liver disease |
| title_full_unstemmed | Correlation analysis of the triglyceride–glucose index and related parameters in metabolic dysfunction-associated fatty liver disease |
| title_short | Correlation analysis of the triglyceride–glucose index and related parameters in metabolic dysfunction-associated fatty liver disease |
| title_sort | correlation analysis of the triglyceride glucose index and related parameters in metabolic dysfunction associated fatty liver disease |
| topic | TyG and related parameters MAFLD Correlation analysis |
| url | https://doi.org/10.1038/s41598-024-84809-y |
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