Key Signaling Pathways Regulate the Development and Survival of Auditory Hair Cells
The loss of auditory sensory hair cells (HCs) is the most common cause of sensorineural hearing loss (SNHL). As the main sound transmission structure in the cochlea, it is necessary to maintain the normal shape and survival of HCs. In this review, we described and summarized the signaling pathways t...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/5522717 |
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| author | Yao Liu Mei Wei Xiang Mao Taisheng Chen Peng Lin Wei Wang |
| author_facet | Yao Liu Mei Wei Xiang Mao Taisheng Chen Peng Lin Wei Wang |
| author_sort | Yao Liu |
| collection | DOAJ |
| description | The loss of auditory sensory hair cells (HCs) is the most common cause of sensorineural hearing loss (SNHL). As the main sound transmission structure in the cochlea, it is necessary to maintain the normal shape and survival of HCs. In this review, we described and summarized the signaling pathways that regulate the development and survival of auditory HCs in SNHL. The role of the mitogen-activated protein kinase (MAPK), phosphoinositide-3 kinase/protein kinase B (PI3K/Akt), Notch/Wnt/Atoh1, calcium channels, and oxidative stress/reactive oxygen species (ROS) signaling pathways are the most relevant. The molecular interactions of these signaling pathways play an important role in the survival of HCs, which may provide a theoretical basis and possible therapeutic interventions for the treatment of hearing loss. |
| format | Article |
| id | doaj-art-1016e1bc98614a30ac90e01e58c94870 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-1016e1bc98614a30ac90e01e58c948702025-02-03T05:47:08ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/55227175522717Key Signaling Pathways Regulate the Development and Survival of Auditory Hair CellsYao Liu0Mei Wei1Xiang Mao2Taisheng Chen3Peng Lin4Wei Wang5Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, 300192 Tianjin, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, 300192 Tianjin, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, 300192 Tianjin, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, 300192 Tianjin, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, 300192 Tianjin, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, 300192 Tianjin, ChinaThe loss of auditory sensory hair cells (HCs) is the most common cause of sensorineural hearing loss (SNHL). As the main sound transmission structure in the cochlea, it is necessary to maintain the normal shape and survival of HCs. In this review, we described and summarized the signaling pathways that regulate the development and survival of auditory HCs in SNHL. The role of the mitogen-activated protein kinase (MAPK), phosphoinositide-3 kinase/protein kinase B (PI3K/Akt), Notch/Wnt/Atoh1, calcium channels, and oxidative stress/reactive oxygen species (ROS) signaling pathways are the most relevant. The molecular interactions of these signaling pathways play an important role in the survival of HCs, which may provide a theoretical basis and possible therapeutic interventions for the treatment of hearing loss.http://dx.doi.org/10.1155/2021/5522717 |
| spellingShingle | Yao Liu Mei Wei Xiang Mao Taisheng Chen Peng Lin Wei Wang Key Signaling Pathways Regulate the Development and Survival of Auditory Hair Cells Neural Plasticity |
| title | Key Signaling Pathways Regulate the Development and Survival of Auditory Hair Cells |
| title_full | Key Signaling Pathways Regulate the Development and Survival of Auditory Hair Cells |
| title_fullStr | Key Signaling Pathways Regulate the Development and Survival of Auditory Hair Cells |
| title_full_unstemmed | Key Signaling Pathways Regulate the Development and Survival of Auditory Hair Cells |
| title_short | Key Signaling Pathways Regulate the Development and Survival of Auditory Hair Cells |
| title_sort | key signaling pathways regulate the development and survival of auditory hair cells |
| url | http://dx.doi.org/10.1155/2021/5522717 |
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