Role of exosomes in diagnosis, prognostication, and treatment of pediatric solid tumors
Cancer is the second leading cause of death in children, and solid tumors make up 30% of childhood cancers. Molecular profiling of pediatric solid tumors allows a personalized approach to therapy, but this approach mostly relies on surgical biopsy, which is invasive and carries the risk of complicat...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Molecular Therapy: Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950329924001723 |
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| author | Shaikh M. Ghufran Morgan L. Brown Elizabeth A. Beierle |
| author_facet | Shaikh M. Ghufran Morgan L. Brown Elizabeth A. Beierle |
| author_sort | Shaikh M. Ghufran |
| collection | DOAJ |
| description | Cancer is the second leading cause of death in children, and solid tumors make up 30% of childhood cancers. Molecular profiling of pediatric solid tumors allows a personalized approach to therapy, but this approach mostly relies on surgical biopsy, which is invasive and carries the risk of complications. Liquid biopsy serves as a reliable alternative and a minimally invasive tool for diagnosing, prognosticating, and residual disease monitoring in childhood cancers. This review outlines the potential of exosomes as informative liquid biopsies in pediatric solid tumors. Studies highlighting the potential applications and clinical utility of exosomes and their molecular constituents as prognosticators and therapies in common childhood solid tumors, including neuroblastoma, medulloblastoma, sarcoma, and hepatoblastoma, have been overviewed. We also discuss the limitations and technical challenges of utilizing exosomes for pediatric solid tumors. |
| format | Article |
| id | doaj-art-0fb4b84872a3441a8cc8d11b832c95d4 |
| institution | Kabale University |
| issn | 2950-3299 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Oncology |
| spelling | doaj-art-0fb4b84872a3441a8cc8d11b832c95d42025-01-16T04:29:32ZengElsevierMolecular Therapy: Oncology2950-32992025-03-01331200930Role of exosomes in diagnosis, prognostication, and treatment of pediatric solid tumorsShaikh M. Ghufran0Morgan L. Brown1Elizabeth A. Beierle2University of Alabama at Birmingham, Department of Surgery, Division of Pediatric Surgery, Birmingham, AL 35233, USAUniversity of Alabama at Birmingham, Department of Surgery, Division of Pediatric Surgery, Birmingham, AL 35233, USAUniversity of Alabama at Birmingham, Department of Surgery, Division of Pediatric Surgery, Birmingham, AL 35233, USA; Corresponding author: Elizabeth A. Beierle, University of Alabama at Birmingham, Department of Surgery, Division of Pediatric Surgery, Birmingham, AL 35233, USA.Cancer is the second leading cause of death in children, and solid tumors make up 30% of childhood cancers. Molecular profiling of pediatric solid tumors allows a personalized approach to therapy, but this approach mostly relies on surgical biopsy, which is invasive and carries the risk of complications. Liquid biopsy serves as a reliable alternative and a minimally invasive tool for diagnosing, prognosticating, and residual disease monitoring in childhood cancers. This review outlines the potential of exosomes as informative liquid biopsies in pediatric solid tumors. Studies highlighting the potential applications and clinical utility of exosomes and their molecular constituents as prognosticators and therapies in common childhood solid tumors, including neuroblastoma, medulloblastoma, sarcoma, and hepatoblastoma, have been overviewed. We also discuss the limitations and technical challenges of utilizing exosomes for pediatric solid tumors.http://www.sciencedirect.com/science/article/pii/S2950329924001723exosomesmiRNAspediatric cancersliquid biopsybiomarkers |
| spellingShingle | Shaikh M. Ghufran Morgan L. Brown Elizabeth A. Beierle Role of exosomes in diagnosis, prognostication, and treatment of pediatric solid tumors Molecular Therapy: Oncology exosomes miRNAs pediatric cancers liquid biopsy biomarkers |
| title | Role of exosomes in diagnosis, prognostication, and treatment of pediatric solid tumors |
| title_full | Role of exosomes in diagnosis, prognostication, and treatment of pediatric solid tumors |
| title_fullStr | Role of exosomes in diagnosis, prognostication, and treatment of pediatric solid tumors |
| title_full_unstemmed | Role of exosomes in diagnosis, prognostication, and treatment of pediatric solid tumors |
| title_short | Role of exosomes in diagnosis, prognostication, and treatment of pediatric solid tumors |
| title_sort | role of exosomes in diagnosis prognostication and treatment of pediatric solid tumors |
| topic | exosomes miRNAs pediatric cancers liquid biopsy biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S2950329924001723 |
| work_keys_str_mv | AT shaikhmghufran roleofexosomesindiagnosisprognosticationandtreatmentofpediatricsolidtumors AT morganlbrown roleofexosomesindiagnosisprognosticationandtreatmentofpediatricsolidtumors AT elizabethabeierle roleofexosomesindiagnosisprognosticationandtreatmentofpediatricsolidtumors |