Sepsis, leukocytes, cytokines and disseminated intravascular coagulation
Leukocytes play an important rote on the pathogenesis of sepsis-induced disseminated intravascular coagulation. Despite the beneficial role ol leukocytes in host delence, these cells may also cause the initation and progression ol tissue injury in sepsis. Cytokines such as tumor necrosis factor* a (...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=62 |
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| _version_ | 1841561387375001600 |
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| author | Ramazan Çöl Zafer Durgun |
| author_facet | Ramazan Çöl Zafer Durgun |
| author_sort | Ramazan Çöl |
| collection | DOAJ |
| description | Leukocytes play an important rote on the pathogenesis of sepsis-induced disseminated intravascular coagulation. Despite the beneficial role ol leukocytes in host delence, these cells may also cause the initation and progression ol tissue injury in sepsis. Cytokines such as tumor necrosis factor* a (TNF-a) and inlerleukin-1 3 (IL-1 P) activate monocytes, neutrophils and endothelial cells. Inflammatory cytokines initate coagulation mechanism by converting endothelium from an antithrombotic surface to a prothrombotic surface. These cytokines activate both the extrinsic and intrinsic coagulation system by stimulating tissue (actor production. Moreover, they activate neutrophils to release inflammatory mediators such as neutrophil elestase and oxygen free radicals. Various pathogenic effects thai occur in sepsis are attributed to the release of oxygen radicals and enzymes from neutrophils. This review present information about leukocytes and their important roles in sepsis. |
| format | Article |
| id | doaj-art-0fb292592f934ce8899155d15f9f4646 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-0fb292592f934ce8899155d15f9f46462025-01-03T01:36:25ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532319710662Sepsis, leukocytes, cytokines and disseminated intravascular coagulationRamazan ÇölZafer DurgunLeukocytes play an important rote on the pathogenesis of sepsis-induced disseminated intravascular coagulation. Despite the beneficial role ol leukocytes in host delence, these cells may also cause the initation and progression ol tissue injury in sepsis. Cytokines such as tumor necrosis factor* a (TNF-a) and inlerleukin-1 3 (IL-1 P) activate monocytes, neutrophils and endothelial cells. Inflammatory cytokines initate coagulation mechanism by converting endothelium from an antithrombotic surface to a prothrombotic surface. These cytokines activate both the extrinsic and intrinsic coagulation system by stimulating tissue (actor production. Moreover, they activate neutrophils to release inflammatory mediators such as neutrophil elestase and oxygen free radicals. Various pathogenic effects thai occur in sepsis are attributed to the release of oxygen radicals and enzymes from neutrophils. This review present information about leukocytes and their important roles in sepsis.http://eurasianjvetsci.org/pdf.php3?id=62disseminated intravascular coagulationsepsisleukocytecytokine |
| spellingShingle | Ramazan Çöl Zafer Durgun Sepsis, leukocytes, cytokines and disseminated intravascular coagulation Eurasian Journal of Veterinary Sciences disseminated intravascular coagulation sepsis leukocyte cytokine |
| title | Sepsis, leukocytes, cytokines and disseminated intravascular coagulation |
| title_full | Sepsis, leukocytes, cytokines and disseminated intravascular coagulation |
| title_fullStr | Sepsis, leukocytes, cytokines and disseminated intravascular coagulation |
| title_full_unstemmed | Sepsis, leukocytes, cytokines and disseminated intravascular coagulation |
| title_short | Sepsis, leukocytes, cytokines and disseminated intravascular coagulation |
| title_sort | sepsis leukocytes cytokines and disseminated intravascular coagulation |
| topic | disseminated intravascular coagulation sepsis leukocyte cytokine |
| url | http://eurasianjvetsci.org/pdf.php3?id=62 |
| work_keys_str_mv | AT ramazancol sepsisleukocytescytokinesanddisseminatedintravascularcoagulation AT zaferdurgun sepsisleukocytescytokinesanddisseminatedintravascularcoagulation |