Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction
Valproic acid-induced hyperammonemic encephalopathy is a rare yet serious adverse drug reaction. Medication interactions such a valproic acid and topiramate can precipitate an event. We present the case of a 52-year-old female that presented with acute mental status change and hypersomnolence due to...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2014/410403 |
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| _version_ | 1849308373122547712 |
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| author | Jennifer D. Twilla Andrew S. Pierce |
| author_facet | Jennifer D. Twilla Andrew S. Pierce |
| author_sort | Jennifer D. Twilla |
| collection | DOAJ |
| description | Valproic acid-induced hyperammonemic encephalopathy is a rare yet serious adverse drug reaction. Medication interactions such a valproic acid and topiramate can precipitate an event. We present the case of a 52-year-old female that presented with acute mental status change and hypersomnolence due to hyperammonemia caused by a valproic acid derivative. The patient improved after withdrawal of the offending medications and treatment with lactulose. Clinicians should remain hypervigilant in monitoring for valproic acid-induced hyperammonemic encephalopathy and risk factors such as polypharmacy. |
| format | Article |
| id | doaj-art-0f9ba94dba664b57a05f914013e77a28 |
| institution | Kabale University |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-0f9ba94dba664b57a05f914013e77a282025-08-20T03:54:28ZengWileyCase Reports in Psychiatry2090-682X2090-68382014-01-01201410.1155/2014/410403410403Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate InteractionJennifer D. Twilla0Andrew S. Pierce1Methodist University Hospital, 1265 Union Avenue Memphis, TN 38104, USAMethodist University Hospital, 1265 Union Avenue Memphis, TN 38104, USAValproic acid-induced hyperammonemic encephalopathy is a rare yet serious adverse drug reaction. Medication interactions such a valproic acid and topiramate can precipitate an event. We present the case of a 52-year-old female that presented with acute mental status change and hypersomnolence due to hyperammonemia caused by a valproic acid derivative. The patient improved after withdrawal of the offending medications and treatment with lactulose. Clinicians should remain hypervigilant in monitoring for valproic acid-induced hyperammonemic encephalopathy and risk factors such as polypharmacy.http://dx.doi.org/10.1155/2014/410403 |
| spellingShingle | Jennifer D. Twilla Andrew S. Pierce Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction Case Reports in Psychiatry |
| title | Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction |
| title_full | Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction |
| title_fullStr | Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction |
| title_full_unstemmed | Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction |
| title_short | Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction |
| title_sort | hyperammonemic encephalopathy due to valproic acid and topiramate interaction |
| url | http://dx.doi.org/10.1155/2014/410403 |
| work_keys_str_mv | AT jenniferdtwilla hyperammonemicencephalopathyduetovalproicacidandtopiramateinteraction AT andrewspierce hyperammonemicencephalopathyduetovalproicacidandtopiramateinteraction |