Surface keratin 1, a tumor-selective peptide target in human triple-negative breast cancer

Surface keratin 1, a tumor-selective peptide target in human triple-negative breast cancer

Abstract Targeting drugs to cancer cells via overexpressed cell-surface receptors has emerged as an effective therapeutic strategy for several cancers. However, identifying cell-surface receptors that allow selective uptake of targeting ligands by cancer cells—while sparing normal cells—remains a ch...

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Bibliographic Details
Main Authors: Shih-Jing Yao, Farideh Amirrad, Elmira Ziaei, Azam Saghaeidehkordi, Moom R. Roosan, Kiumars Shamloo, Ajay Sharma, Rachita K. Sumbria, Surya M. Nauli, Christopher G. Bunick, Kamaljit Kaur
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
TNBC
Keratin 1 expression
Cell-surface keratin 1
Targeted drug delivery
Tumor-selective peptide
Online Access:https://doi.org/10.1038/s41598-025-05351-z
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