Comparative meta-analysis of transcriptomic studies in spinal muscular atrophy: comparison between tissues and mouse models

Comparative meta-analysis of transcriptomic studies in spinal muscular atrophy: comparison between tissues and mouse models

Abstract Background Spinal Muscular Atrophy (SMA), a neuromuscular disorder that leads to weakness in the muscles due to degeneration of motor neurons. Mutations in the survival motor neuron 1 (SMN1) gene leads to the deficiency of SMN protein that causes SMA. The molecular alterations associated wi...

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Bibliographic Details
Main Authors: Shamini Hemandhar Kumar, Katharina Brandt, Peter Claus, Klaus Jung
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Medical Genomics
Subjects:
Differential expression analysis
Meta-analysis
Network reconstruction
Spinal muscular atrophy
Transcriptomics
WGCNA
Online Access:https://doi.org/10.1186/s12920-024-02040-0
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