PREGNANCY LOSS IN WOMEN WITH HIV IS NOT ASSOCIATED WITH HIV MARKERS: DATA FROM A NATIONAL STUDY IN ITALY, 2001-2018
Background: There is limited information on pregnancy loss in women with HIV, and it is still debate whether HIV-related markers may play a role. Objectives: To explore potential risk factors for pregnancy loss in women with HIV, with particular reference to modifiable risk factors and markers of...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2019-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://mjhid.org/index.php/mjhid/article/view/3969 |
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| author | Marco Floridia Giulia Masuelli Beatrice Tassis Enrica Tamburrini Valeria Savasi Matilde Sansone Arsenio Spinillo Giuseppina Liuzzi Anna Degli Antoni Serena Dalzero Laura Franceschetti Giuliana Simonazzi Gianpaolo Maso Daniela Francisci Carmela Pinnetti Marina Ravizza |
| author_facet | Marco Floridia Giulia Masuelli Beatrice Tassis Enrica Tamburrini Valeria Savasi Matilde Sansone Arsenio Spinillo Giuseppina Liuzzi Anna Degli Antoni Serena Dalzero Laura Franceschetti Giuliana Simonazzi Gianpaolo Maso Daniela Francisci Carmela Pinnetti Marina Ravizza |
| author_sort | Marco Floridia |
| collection | DOAJ |
| description | Background: There is limited information on pregnancy loss in women with HIV, and it is still debate whether HIV-related markers may play a role.
Objectives: To explore potential risk factors for pregnancy loss in women with HIV, with particular reference to modifiable risk factors and markers of HIV disease.
Methods: Multicenter observational study of HIV-positive pregnant women. The main outcome measure was pregnancy loss, including both miscarriage (<22 weeks) and stillbirth (≥22 weeks). Possible associations of pregnancy loss were evaluated in univariate and multivariate analyses.
Results: Among 2696 eligible pregnancies reported between 2001 and 2018, 226 (8.4%) ended in pregnancy loss (miscarriage 198, 7.3%; stillbirth 28, 1.0%). In multivariate analyses, only older age (adjusted odds ratio [AOR] per additional year of age: 1.079, 95% confidence interval [CI] 1.046.1.113), HIV diagnosis before pregnancy (AOR: 2.533, 95%CI 1.407-4.561) and history of pregnancy loss (AOR: 1.625, 95%CI 1.178-2.243) were significantly associated with pregnancy loss. No significant association with pregnancy loss was found for parity, coinfections, sexually transmitted diseases, hypertension, smoking, alcohol and substance use, CD4 cell count, HIV-RNA viral load and CDC HIV stage.
Conclusions: Older women and those with a previous history of pregnancy loss should be considered at higher risk of pregnancy loss. The severity of HIV disease and potentially modifiable risk factors apparently did not increase the risk of pregnancy loss. |
| format | Article |
| id | doaj-art-0f88cb032eae4852a196fb4f17d0ce11 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-0f88cb032eae4852a196fb4f17d0ce112025-01-02T00:32:50ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062019-08-0111110.4084/mjhid.2019.050PREGNANCY LOSS IN WOMEN WITH HIV IS NOT ASSOCIATED WITH HIV MARKERS: DATA FROM A NATIONAL STUDY IN ITALY, 2001-2018Marco Floridia0Giulia MasuelliBeatrice TassisEnrica TamburriniValeria SavasiMatilde SansoneArsenio SpinilloGiuseppina LiuzziAnna Degli AntoniSerena DalzeroLaura FranceschettiGiuliana SimonazziGianpaolo MasoDaniela FrancisciCarmela PinnettiMarina RavizzaIstituto Superiore di SanitàBackground: There is limited information on pregnancy loss in women with HIV, and it is still debate whether HIV-related markers may play a role. Objectives: To explore potential risk factors for pregnancy loss in women with HIV, with particular reference to modifiable risk factors and markers of HIV disease. Methods: Multicenter observational study of HIV-positive pregnant women. The main outcome measure was pregnancy loss, including both miscarriage (<22 weeks) and stillbirth (≥22 weeks). Possible associations of pregnancy loss were evaluated in univariate and multivariate analyses. Results: Among 2696 eligible pregnancies reported between 2001 and 2018, 226 (8.4%) ended in pregnancy loss (miscarriage 198, 7.3%; stillbirth 28, 1.0%). In multivariate analyses, only older age (adjusted odds ratio [AOR] per additional year of age: 1.079, 95% confidence interval [CI] 1.046.1.113), HIV diagnosis before pregnancy (AOR: 2.533, 95%CI 1.407-4.561) and history of pregnancy loss (AOR: 1.625, 95%CI 1.178-2.243) were significantly associated with pregnancy loss. No significant association with pregnancy loss was found for parity, coinfections, sexually transmitted diseases, hypertension, smoking, alcohol and substance use, CD4 cell count, HIV-RNA viral load and CDC HIV stage. Conclusions: Older women and those with a previous history of pregnancy loss should be considered at higher risk of pregnancy loss. The severity of HIV disease and potentially modifiable risk factors apparently did not increase the risk of pregnancy loss.http://mjhid.org/index.php/mjhid/article/view/3969HIV; miscarriage; stillbirth; CD4 cell count; pregnancy loss. |
| spellingShingle | Marco Floridia Giulia Masuelli Beatrice Tassis Enrica Tamburrini Valeria Savasi Matilde Sansone Arsenio Spinillo Giuseppina Liuzzi Anna Degli Antoni Serena Dalzero Laura Franceschetti Giuliana Simonazzi Gianpaolo Maso Daniela Francisci Carmela Pinnetti Marina Ravizza PREGNANCY LOSS IN WOMEN WITH HIV IS NOT ASSOCIATED WITH HIV MARKERS: DATA FROM A NATIONAL STUDY IN ITALY, 2001-2018 Mediterranean Journal of Hematology and Infectious Diseases HIV; miscarriage; stillbirth; CD4 cell count; pregnancy loss. |
| title | PREGNANCY LOSS IN WOMEN WITH HIV IS NOT ASSOCIATED WITH HIV MARKERS: DATA FROM A NATIONAL STUDY IN ITALY, 2001-2018 |
| title_full | PREGNANCY LOSS IN WOMEN WITH HIV IS NOT ASSOCIATED WITH HIV MARKERS: DATA FROM A NATIONAL STUDY IN ITALY, 2001-2018 |
| title_fullStr | PREGNANCY LOSS IN WOMEN WITH HIV IS NOT ASSOCIATED WITH HIV MARKERS: DATA FROM A NATIONAL STUDY IN ITALY, 2001-2018 |
| title_full_unstemmed | PREGNANCY LOSS IN WOMEN WITH HIV IS NOT ASSOCIATED WITH HIV MARKERS: DATA FROM A NATIONAL STUDY IN ITALY, 2001-2018 |
| title_short | PREGNANCY LOSS IN WOMEN WITH HIV IS NOT ASSOCIATED WITH HIV MARKERS: DATA FROM A NATIONAL STUDY IN ITALY, 2001-2018 |
| title_sort | pregnancy loss in women with hiv is not associated with hiv markers data from a national study in italy 2001 2018 |
| topic | HIV; miscarriage; stillbirth; CD4 cell count; pregnancy loss. |
| url | http://mjhid.org/index.php/mjhid/article/view/3969 |
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