Shared signaling pathways and comprehensive therapeutic approaches among diabetes complications
The growing global prevalence of diabetes mellitus (DM), along with its associated complications, continues to rise. When clinically detected most DM complications are irreversible. It is therefore crucial to detect and address these complications early and systematically in order to improve patient...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1497750/full |
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| author | Moein Ebrahimi Hamid Ahmadieh Mozhgan Rezaei Kanavi Sare Safi Saeed Alipour-Parsa Soroor Advani Christine M. Sorenson Nader Sheibani |
| author_facet | Moein Ebrahimi Hamid Ahmadieh Mozhgan Rezaei Kanavi Sare Safi Saeed Alipour-Parsa Soroor Advani Christine M. Sorenson Nader Sheibani |
| author_sort | Moein Ebrahimi |
| collection | DOAJ |
| description | The growing global prevalence of diabetes mellitus (DM), along with its associated complications, continues to rise. When clinically detected most DM complications are irreversible. It is therefore crucial to detect and address these complications early and systematically in order to improve patient care and outcomes. The current clinical practice often prioritizes DM complications by addressing one complication while overlooking others that could occur. It is proposed that the commonly targeted cell types including vascular cells, immune cells, glial cells, and fibroblasts that mediate DM complications, might share early responses to diabetes. In addition, the impact of one complication could be influenced by other complications. Recognizing and focusing on the shared early responses among DM complications, and the impacted cellular constituents, will allow to simultaneously address all DM-related complications and limit adverse treatment impacts. This review explores the current understanding of shared pathological signaling mechanisms among DM complications and recognizes new concepts that will benefit from further investigation in both basic and clinical settings. The ultimate goal is to develop more comprehensive treatment strategies, which effectively impact DM complications in multiple organs and improve patient care and outcomes. |
| format | Article |
| id | doaj-art-0f74b2c7c2e6471aa88ed8b21859b212 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-0f74b2c7c2e6471aa88ed8b21859b2122025-01-08T06:11:47ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.14977501497750Shared signaling pathways and comprehensive therapeutic approaches among diabetes complicationsMoein Ebrahimi0Hamid Ahmadieh1Mozhgan Rezaei Kanavi2Sare Safi3Saeed Alipour-Parsa4Soroor Advani5Christine M. Sorenson6Nader Sheibani7School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranOphthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, IranOcular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, IranOphthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, IranCardiovascular Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranNeurology Department, Shohada Tajrish Hospital, Shahid-Beheshti University of Medical Sciences, Tehran, IranDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesThe growing global prevalence of diabetes mellitus (DM), along with its associated complications, continues to rise. When clinically detected most DM complications are irreversible. It is therefore crucial to detect and address these complications early and systematically in order to improve patient care and outcomes. The current clinical practice often prioritizes DM complications by addressing one complication while overlooking others that could occur. It is proposed that the commonly targeted cell types including vascular cells, immune cells, glial cells, and fibroblasts that mediate DM complications, might share early responses to diabetes. In addition, the impact of one complication could be influenced by other complications. Recognizing and focusing on the shared early responses among DM complications, and the impacted cellular constituents, will allow to simultaneously address all DM-related complications and limit adverse treatment impacts. This review explores the current understanding of shared pathological signaling mechanisms among DM complications and recognizes new concepts that will benefit from further investigation in both basic and clinical settings. The ultimate goal is to develop more comprehensive treatment strategies, which effectively impact DM complications in multiple organs and improve patient care and outcomes.https://www.frontiersin.org/articles/10.3389/fmed.2024.1497750/fulldiabetic retinopathydiabetic nephropathydiabetic neuropathydiabetic cardiomyopathysignal transductiontherapeutic targeting |
| spellingShingle | Moein Ebrahimi Hamid Ahmadieh Mozhgan Rezaei Kanavi Sare Safi Saeed Alipour-Parsa Soroor Advani Christine M. Sorenson Nader Sheibani Shared signaling pathways and comprehensive therapeutic approaches among diabetes complications Frontiers in Medicine diabetic retinopathy diabetic nephropathy diabetic neuropathy diabetic cardiomyopathy signal transduction therapeutic targeting |
| title | Shared signaling pathways and comprehensive therapeutic approaches among diabetes complications |
| title_full | Shared signaling pathways and comprehensive therapeutic approaches among diabetes complications |
| title_fullStr | Shared signaling pathways and comprehensive therapeutic approaches among diabetes complications |
| title_full_unstemmed | Shared signaling pathways and comprehensive therapeutic approaches among diabetes complications |
| title_short | Shared signaling pathways and comprehensive therapeutic approaches among diabetes complications |
| title_sort | shared signaling pathways and comprehensive therapeutic approaches among diabetes complications |
| topic | diabetic retinopathy diabetic nephropathy diabetic neuropathy diabetic cardiomyopathy signal transduction therapeutic targeting |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1497750/full |
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