Association Between Plasma ADAMTS-7 Levels and Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus
A disintegrin and metalloproteinase with thrombospondin motifs-7 (ADAMTS-7) belongs to the family of metalloproteinases that contributes to tissue homeostasis during morphogenesis and reproduction. These metalloproteinases regulate various cell functions such as cell proliferation, are important reg...
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| author | Asimina Ganotopoulou Emmanouil Korakas Loukia Pliouta Aikaterini Kountouri Sotirios Pililis Stamatios Lampsas Ignatios Ikonomidis Loukianos S. Rallidis Athanasia Papazafiropoulou Andreas Melidonis Vaia Lambadiari |
| author_facet | Asimina Ganotopoulou Emmanouil Korakas Loukia Pliouta Aikaterini Kountouri Sotirios Pililis Stamatios Lampsas Ignatios Ikonomidis Loukianos S. Rallidis Athanasia Papazafiropoulou Andreas Melidonis Vaia Lambadiari |
| author_sort | Asimina Ganotopoulou |
| collection | DOAJ |
| description | A disintegrin and metalloproteinase with thrombospondin motifs-7 (ADAMTS-7) belongs to the family of metalloproteinases that contributes to tissue homeostasis during morphogenesis and reproduction. These metalloproteinases regulate various cell functions such as cell proliferation, are important regulators in tissue regeneration, and play a role in vascular remodelling, which is involved in atherosclerosis development. Despite the well-established association between ADAMTS-7 and atherosclerotic disease, data regarding the metalloproteinase’s association with LV function remain scarce. The aim of this study was to investigate the association of ADAMTS-7 levels with diastolic dysfunction and various echocardiographic parameters in patients with type 2 diabetes mellitus. All patients underwent a clinical, vascular, and echocardiographic examination during their visit. Plasma ADAMTS-7 levels were measured in all patients. The results showed that diastolic dysfunction was strongly associated with age, but had no statistically significant association with ADAMTS-7. When individual echocardiographic parameters were examined, ADAMTS-7 levels showed a positive tendency only with deceleration time (DT), with the other echocardiographic parameters being positively associated only with age. The possible role of ADAMTS-7 in diastolic dysfunction and in the development and progression of heart failure in patients with type 2 diabetes mellitus deserves further investigation. |
| format | Article |
| id | doaj-art-0f57debcc54f49c39a7c3e4cca77478f |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-0f57debcc54f49c39a7c3e4cca77478f2024-12-27T14:38:43ZengMDPI AGMedicina1010-660X1648-91442024-12-016012198110.3390/medicina60121981Association Between Plasma ADAMTS-7 Levels and Diastolic Dysfunction in Patients with Type 2 Diabetes MellitusAsimina Ganotopoulou0Emmanouil Korakas1Loukia Pliouta2Aikaterini Kountouri3Sotirios Pililis4Stamatios Lampsas5Ignatios Ikonomidis6Loukianos S. Rallidis7Athanasia Papazafiropoulou8Andreas Melidonis9Vaia Lambadiari10Research Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, GreeceResearch Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, GreeceResearch Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, GreeceResearch Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, GreeceResearch Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece2nd Department of Ophthalmology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece2nd Department of Cardiology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece2nd Department of Cardiology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, GreeceDepartment of Internal Medicine and Diabetes Centre, Tzaneio General Hospital of Piraeus, 185 36 Piraeus, GreeceDepartment of Internal Medicine and Diabetes Centre, Tzaneio General Hospital of Piraeus, 185 36 Piraeus, GreeceResearch Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, GreeceA disintegrin and metalloproteinase with thrombospondin motifs-7 (ADAMTS-7) belongs to the family of metalloproteinases that contributes to tissue homeostasis during morphogenesis and reproduction. These metalloproteinases regulate various cell functions such as cell proliferation, are important regulators in tissue regeneration, and play a role in vascular remodelling, which is involved in atherosclerosis development. Despite the well-established association between ADAMTS-7 and atherosclerotic disease, data regarding the metalloproteinase’s association with LV function remain scarce. The aim of this study was to investigate the association of ADAMTS-7 levels with diastolic dysfunction and various echocardiographic parameters in patients with type 2 diabetes mellitus. All patients underwent a clinical, vascular, and echocardiographic examination during their visit. Plasma ADAMTS-7 levels were measured in all patients. The results showed that diastolic dysfunction was strongly associated with age, but had no statistically significant association with ADAMTS-7. When individual echocardiographic parameters were examined, ADAMTS-7 levels showed a positive tendency only with deceleration time (DT), with the other echocardiographic parameters being positively associated only with age. The possible role of ADAMTS-7 in diastolic dysfunction and in the development and progression of heart failure in patients with type 2 diabetes mellitus deserves further investigation.https://www.mdpi.com/1648-9144/60/12/1981biomarkersdiabetes mellitusheart failureADAMTS-7metalloproteinasesatherosclerosis |
| spellingShingle | Asimina Ganotopoulou Emmanouil Korakas Loukia Pliouta Aikaterini Kountouri Sotirios Pililis Stamatios Lampsas Ignatios Ikonomidis Loukianos S. Rallidis Athanasia Papazafiropoulou Andreas Melidonis Vaia Lambadiari Association Between Plasma ADAMTS-7 Levels and Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus Medicina biomarkers diabetes mellitus heart failure ADAMTS-7 metalloproteinases atherosclerosis |
| title | Association Between Plasma ADAMTS-7 Levels and Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus |
| title_full | Association Between Plasma ADAMTS-7 Levels and Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Association Between Plasma ADAMTS-7 Levels and Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Association Between Plasma ADAMTS-7 Levels and Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus |
| title_short | Association Between Plasma ADAMTS-7 Levels and Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus |
| title_sort | association between plasma adamts 7 levels and diastolic dysfunction in patients with type 2 diabetes mellitus |
| topic | biomarkers diabetes mellitus heart failure ADAMTS-7 metalloproteinases atherosclerosis |
| url | https://www.mdpi.com/1648-9144/60/12/1981 |
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