Fetal ECG-based analysis reveals the impact of fetal movements and maternal respiration on maternal-fetal heart rate synchronization.
Identifying and understanding prenatal developmental disorders at an early stage are crucial as fetal brain development has long-term effects on an individual's life. The maturation of the fetal autonomic nervous system (ANS) is believed to influence the coordination and direction of maternal-f...
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2024-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0312310 |
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| author | Amna Samjeed Maisam Wahbah Leontios Hadjileontiadis Ahsan H Khandoker |
| author_facet | Amna Samjeed Maisam Wahbah Leontios Hadjileontiadis Ahsan H Khandoker |
| author_sort | Amna Samjeed |
| collection | DOAJ |
| description | Identifying and understanding prenatal developmental disorders at an early stage are crucial as fetal brain development has long-term effects on an individual's life. The maturation of the fetal autonomic nervous system (ANS) is believed to influence the coordination and direction of maternal-fetal heartbeat synchronization. Fetal behavioral states (FBSes) include quiet sleep (1F), active sleep (2F), quiet awake (3F), and active awake (4F). In this study, the focus is on fetal movements, leading to the grouping of 1F and 3F into a quiet state, while 2F and 4F are combined to form an active state. Thus, the FBSes discussed in this article consist of fetal quiet and active states. Here, we explore the relationship between FBSes and the coupling of maternal and fetal heartbeats. We also seek to understand how maternal breathing patterns influence this coupling while considering FBSes. The study involved 105 healthy fetuses with gestational ages (GA) from 20 to 40 weeks. Non-invasive electrocardiogram (ECG) signals were recorded for 3 to 10 minutes. The ECG samples were separated into three gestational groups (Early: 16 ≤ GA < 25, Mid: 25 ≤ GA < 32, and Late: 32 ≤ GA < 40 weeks). Maternal respiration rate and coupling strength parameters were calculated for various maternal-fetal heartbeat coupling ratios. The findings of the study indicated that FBSes influenced maternal-fetal HR coupling strength during late gestation but not during early and mid-gestation. The changes in maternal-fetal HR synchronization or communication as gestation progresses occur in both FBSes. Furthermore, we noticed a significantly higher level of maternal-fetal heartbeat synchronization during periods of higher respiratory rates when the fetus was in a quiet state. These results emphasize how FBSes impact the synchronization of maternal-fetal HR and contribute to the understanding of fetal growth and health. |
| format | Article |
| id | doaj-art-0f4712c2947a459baac1c27ba0ba4b31 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-0f4712c2947a459baac1c27ba0ba4b312024-12-06T05:31:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011912e031231010.1371/journal.pone.0312310Fetal ECG-based analysis reveals the impact of fetal movements and maternal respiration on maternal-fetal heart rate synchronization.Amna SamjeedMaisam WahbahLeontios HadjileontiadisAhsan H KhandokerIdentifying and understanding prenatal developmental disorders at an early stage are crucial as fetal brain development has long-term effects on an individual's life. The maturation of the fetal autonomic nervous system (ANS) is believed to influence the coordination and direction of maternal-fetal heartbeat synchronization. Fetal behavioral states (FBSes) include quiet sleep (1F), active sleep (2F), quiet awake (3F), and active awake (4F). In this study, the focus is on fetal movements, leading to the grouping of 1F and 3F into a quiet state, while 2F and 4F are combined to form an active state. Thus, the FBSes discussed in this article consist of fetal quiet and active states. Here, we explore the relationship between FBSes and the coupling of maternal and fetal heartbeats. We also seek to understand how maternal breathing patterns influence this coupling while considering FBSes. The study involved 105 healthy fetuses with gestational ages (GA) from 20 to 40 weeks. Non-invasive electrocardiogram (ECG) signals were recorded for 3 to 10 minutes. The ECG samples were separated into three gestational groups (Early: 16 ≤ GA < 25, Mid: 25 ≤ GA < 32, and Late: 32 ≤ GA < 40 weeks). Maternal respiration rate and coupling strength parameters were calculated for various maternal-fetal heartbeat coupling ratios. The findings of the study indicated that FBSes influenced maternal-fetal HR coupling strength during late gestation but not during early and mid-gestation. The changes in maternal-fetal HR synchronization or communication as gestation progresses occur in both FBSes. Furthermore, we noticed a significantly higher level of maternal-fetal heartbeat synchronization during periods of higher respiratory rates when the fetus was in a quiet state. These results emphasize how FBSes impact the synchronization of maternal-fetal HR and contribute to the understanding of fetal growth and health.https://doi.org/10.1371/journal.pone.0312310 |
| spellingShingle | Amna Samjeed Maisam Wahbah Leontios Hadjileontiadis Ahsan H Khandoker Fetal ECG-based analysis reveals the impact of fetal movements and maternal respiration on maternal-fetal heart rate synchronization. PLoS ONE |
| title | Fetal ECG-based analysis reveals the impact of fetal movements and maternal respiration on maternal-fetal heart rate synchronization. |
| title_full | Fetal ECG-based analysis reveals the impact of fetal movements and maternal respiration on maternal-fetal heart rate synchronization. |
| title_fullStr | Fetal ECG-based analysis reveals the impact of fetal movements and maternal respiration on maternal-fetal heart rate synchronization. |
| title_full_unstemmed | Fetal ECG-based analysis reveals the impact of fetal movements and maternal respiration on maternal-fetal heart rate synchronization. |
| title_short | Fetal ECG-based analysis reveals the impact of fetal movements and maternal respiration on maternal-fetal heart rate synchronization. |
| title_sort | fetal ecg based analysis reveals the impact of fetal movements and maternal respiration on maternal fetal heart rate synchronization |
| url | https://doi.org/10.1371/journal.pone.0312310 |
| work_keys_str_mv | AT amnasamjeed fetalecgbasedanalysisrevealstheimpactoffetalmovementsandmaternalrespirationonmaternalfetalheartratesynchronization AT maisamwahbah fetalecgbasedanalysisrevealstheimpactoffetalmovementsandmaternalrespirationonmaternalfetalheartratesynchronization AT leontioshadjileontiadis fetalecgbasedanalysisrevealstheimpactoffetalmovementsandmaternalrespirationonmaternalfetalheartratesynchronization AT ahsanhkhandoker fetalecgbasedanalysisrevealstheimpactoffetalmovementsandmaternalrespirationonmaternalfetalheartratesynchronization |