The structure, functions and clinical significance of the glymphatic system
The glymphatic system is a newly discovered waste cleaning system. It provides active removal of metabolites and soluble proteins from the central nervous system (CNS). This system, formed by Aquaporin- 4 water channels (AQP-4) located on astrocytes and their cytoplasmic extensions, has an unlike pe...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2021-12-01
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1378 |
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| Summary: | The glymphatic system is a newly discovered waste cleaning system.
It provides active removal of metabolites and soluble proteins from
the central nervous system (CNS). This system, formed by Aquaporin-
4 water channels (AQP-4) located on astrocytes and their
cytoplasmic extensions, has an unlike perivascular canal network.
It is remarkable that this system is active during sleep and cannot
acts during the wakefulness process. The functioning of the current
system in sleep state and the removal of neurotoxic waste products
from the CNS accordingly reveal the importance of the biological requirement
for sleep. Since the concept of the glymphatic system is
a relatively new concept, we will evaluate its clinical significance in
this review by looking at its basic structural elements, functions, and
relationship with some certain neurodegenerative diseases. We will
give information about some research showing that various diseases
causing the functional impairment of the glymphatic system and also
which diseases the functional impairment of the glymphatic system
may cause. |
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| ISSN: | 1309-6958 2146-1953 |