A neglected complication of COVID-19: liver injury
[Abstract]: Coronavirus disease-2019 (COVID-19) not only causes substantial respiratory pathology, but also results in several extrapulmonary manifestations, including thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal sym...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2021-03-01
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| Series: | Journal of Holistic Integrative Pharmacy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2707368823000195 |
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| author | Tian LAN Xiaolin LIANG Xiaoyu HU Wuping WANG Laiyou WANG Ling YANG Lexun WANG Xianglu RONG Jiao GUO |
| author_facet | Tian LAN Xiaolin LIANG Xiaoyu HU Wuping WANG Laiyou WANG Ling YANG Lexun WANG Xianglu RONG Jiao GUO |
| author_sort | Tian LAN |
| collection | DOAJ |
| description | [Abstract]: Coronavirus disease-2019 (COVID-19) not only causes substantial respiratory pathology, but also results in several extrapulmonary manifestations, including thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologicillnesses, ocular symptoms, and dermatologic complications. Given that ACE2, the entry receptor for the causative coronavirus SARS-CoV-2, is expressed in multiple extrapulmonary tissues, direct viral tissue damage is a plausible mechanism of injury. In addition, endothelial damage and thromboinflammation, dysregulation of immune responses, and maladaptation of ACE2-related pathways might all contribute to these extrapulmonary manifestations of COVID-19. Recent reports showed about 2%-11% of patients with COVID-19 had underlying chronic liver diseases. Here we reviewed the liver-specific pathophysiology, presentations and management considerations for patients with COVID-19 to aid clinicians and scientists in recognizing and monitoring the spectrum of manifestations, and in developing research priorities and therapeutic strategies for liver injury in COVID-19. |
| format | Article |
| id | doaj-art-0f0f0680998045de8a4e530eb3b51edb |
| institution | Kabale University |
| issn | 2707-3688 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Holistic Integrative Pharmacy |
| spelling | doaj-art-0f0f0680998045de8a4e530eb3b51edb2024-11-12T05:21:28ZengKeAi Communications Co., Ltd.Journal of Holistic Integrative Pharmacy2707-36882021-03-01211119A neglected complication of COVID-19: liver injuryTian LAN0Xiaolin LIANG1Xiaoyu HU2Wuping WANG3Laiyou WANG4Ling YANG5Lexun WANG6Xianglu RONG7Jiao GUO8Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China; [Corresponding author][Abstract]: Coronavirus disease-2019 (COVID-19) not only causes substantial respiratory pathology, but also results in several extrapulmonary manifestations, including thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologicillnesses, ocular symptoms, and dermatologic complications. Given that ACE2, the entry receptor for the causative coronavirus SARS-CoV-2, is expressed in multiple extrapulmonary tissues, direct viral tissue damage is a plausible mechanism of injury. In addition, endothelial damage and thromboinflammation, dysregulation of immune responses, and maladaptation of ACE2-related pathways might all contribute to these extrapulmonary manifestations of COVID-19. Recent reports showed about 2%-11% of patients with COVID-19 had underlying chronic liver diseases. Here we reviewed the liver-specific pathophysiology, presentations and management considerations for patients with COVID-19 to aid clinicians and scientists in recognizing and monitoring the spectrum of manifestations, and in developing research priorities and therapeutic strategies for liver injury in COVID-19.http://www.sciencedirect.com/science/article/pii/S2707368823000195COVID-19SARS-CoV-2Liver injuryPathophysiologyTherapy |
| spellingShingle | Tian LAN Xiaolin LIANG Xiaoyu HU Wuping WANG Laiyou WANG Ling YANG Lexun WANG Xianglu RONG Jiao GUO A neglected complication of COVID-19: liver injury Journal of Holistic Integrative Pharmacy COVID-19 SARS-CoV-2 Liver injury Pathophysiology Therapy |
| title | A neglected complication of COVID-19: liver injury |
| title_full | A neglected complication of COVID-19: liver injury |
| title_fullStr | A neglected complication of COVID-19: liver injury |
| title_full_unstemmed | A neglected complication of COVID-19: liver injury |
| title_short | A neglected complication of COVID-19: liver injury |
| title_sort | neglected complication of covid 19 liver injury |
| topic | COVID-19 SARS-CoV-2 Liver injury Pathophysiology Therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2707368823000195 |
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