Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies
Abstract Exosomes are small extracellular vesicles of endocytic origin released by various cell types. They consist of lipid bilayers containing macromolecules such as lipids, proteins, microRNAs, growth factors, cytokines, and carbohydrates. Exosomes play a critical role in the diagnosis and treatm...
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| Format: | Article |
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BMC
2025-01-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-024-04125-0 |
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| author | Amirata Mohseni Fatemeh Salehi Samaneh Rostami Kaveh Hadiloo Mehrdad Hashemi Zahra Baridjavadi Fatemeh Ahangari Najibeh Karami Fatemeh Samani Safa Tahmasebi Najma Farahani Afshin Taheriazam |
| author_facet | Amirata Mohseni Fatemeh Salehi Samaneh Rostami Kaveh Hadiloo Mehrdad Hashemi Zahra Baridjavadi Fatemeh Ahangari Najibeh Karami Fatemeh Samani Safa Tahmasebi Najma Farahani Afshin Taheriazam |
| author_sort | Amirata Mohseni |
| collection | DOAJ |
| description | Abstract Exosomes are small extracellular vesicles of endocytic origin released by various cell types. They consist of lipid bilayers containing macromolecules such as lipids, proteins, microRNAs, growth factors, cytokines, and carbohydrates. Exosomes play a critical role in the diagnosis and treatment of various diseases. For instance, exosome contents have been utilized as biomarkers in body fluids (urine, saliva, serum) to identify cancers, autoimmune diseases, and inflammatory conditions such as sepsis. Due to their small size and ability to reach tumor microenvironments, exosomes are also used as carriers for chemotherapeutic drugs in drug delivery systems. Furthermore, evidence indicates that malignant cells release exosomes into the tumor microenvironment, influencing immune cells in a paracrine manner. Additionally, immune cell-derived exosomes, such as those from Natural Killer (NK) cells or cytotoxic T lymphocytes (CTLs), show potential as therapeutic agents in treating malignancies like leukemia. This review discusses the diagnostic role of exosomes in various hematological malignancies and explores the therapeutic potential of immune cell-derived exosomes in these diseases. |
| format | Article |
| id | doaj-art-0ef45c81129c45bbaf6a57b5d60f3afb |
| institution | Kabale University |
| issn | 1757-6512 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-0ef45c81129c45bbaf6a57b5d60f3afb2025-01-12T12:10:20ZengBMCStem Cell Research & Therapy1757-65122025-01-0116112810.1186/s13287-024-04125-0Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignanciesAmirata Mohseni0Fatemeh Salehi1Samaneh Rostami2Kaveh Hadiloo3Mehrdad Hashemi4Zahra Baridjavadi5Fatemeh Ahangari6Najibeh Karami7Fatemeh Samani8Safa Tahmasebi9Najma Farahani10Afshin Taheriazam11Department of Molecular Medicine, University of PaviaDepartment of Molecular Medicine, University of PaviaSchool of Medicine, Zanjan University of Medical SciencesSchool of Medicine, Zanjan University of Medical SciencesFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad UniversityDepartment of Immunology, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Immunology, Pasteur Institue of IranHematology-Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical SciencesBlood Transfusion Research Center, High Institute for Research and Education in transfusion medicine, Iranian Blood Transfusion Organization (IBTO)Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical SciencesFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad UniversityDepartment of Orthopedics, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad UniversityAbstract Exosomes are small extracellular vesicles of endocytic origin released by various cell types. They consist of lipid bilayers containing macromolecules such as lipids, proteins, microRNAs, growth factors, cytokines, and carbohydrates. Exosomes play a critical role in the diagnosis and treatment of various diseases. For instance, exosome contents have been utilized as biomarkers in body fluids (urine, saliva, serum) to identify cancers, autoimmune diseases, and inflammatory conditions such as sepsis. Due to their small size and ability to reach tumor microenvironments, exosomes are also used as carriers for chemotherapeutic drugs in drug delivery systems. Furthermore, evidence indicates that malignant cells release exosomes into the tumor microenvironment, influencing immune cells in a paracrine manner. Additionally, immune cell-derived exosomes, such as those from Natural Killer (NK) cells or cytotoxic T lymphocytes (CTLs), show potential as therapeutic agents in treating malignancies like leukemia. This review discusses the diagnostic role of exosomes in various hematological malignancies and explores the therapeutic potential of immune cell-derived exosomes in these diseases.https://doi.org/10.1186/s13287-024-04125-0Small extracellular vesiclesExosomesStem cellMicroRNAsHematological malignancies |
| spellingShingle | Amirata Mohseni Fatemeh Salehi Samaneh Rostami Kaveh Hadiloo Mehrdad Hashemi Zahra Baridjavadi Fatemeh Ahangari Najibeh Karami Fatemeh Samani Safa Tahmasebi Najma Farahani Afshin Taheriazam Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies Stem Cell Research & Therapy Small extracellular vesicles Exosomes Stem cell MicroRNAs Hematological malignancies |
| title | Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies |
| title_full | Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies |
| title_fullStr | Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies |
| title_full_unstemmed | Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies |
| title_short | Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies |
| title_sort | harnessing the power of exosomes for diagnosis prognosis and treatment of hematological malignancies |
| topic | Small extracellular vesicles Exosomes Stem cell MicroRNAs Hematological malignancies |
| url | https://doi.org/10.1186/s13287-024-04125-0 |
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