Differential T cell accumulation within intracranial and subcutaneous melanomas is associated with differences in intratumoral myeloid cells

Differential T cell accumulation within intracranial and subcutaneous melanomas is associated with differences in intratumoral myeloid cells

Abstract Patients with metastatic brain melanomas (MBM) experience shorter-lasting survival than patients with extracranial metastases, and this is associated with a higher fraction of dysfunctional CD8 T cells. The goal of this study was to understand the underlying cause of T cell dysfunction in M...

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Main Authors: Katarzyna Stasiak, Aaron D. Stevens, Ashley C. Bolte, Colleen T. Curley, Mirna Perusina Lanfranca, Robin S. Lindsay, Ukpong B. Eyo, John R. Lukens, Richard J. Price, Timothy N. J. Bullock, Victor H. Engelhard
Format: Article
Language:English
Published: Springer 2024-11-01
Series:Cancer Immunology, Immunotherapy
Subjects:
T cells
Melanoma
Metastasis
Brain
Antigen presenting cells
Online Access:https://doi.org/10.1007/s00262-024-03832-0
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